Processo de produção verde de dissulfetos a partir de tióis mediado por iodeto de amônio

Abstract

The synthesis of disulfides, sulfur-containing compounds found in the structures of aminoacids, enzymes, and pharmaceuticals, is essential for the development of new classes of drugs. However, traditional methodologies often employ toxic solvents, heavy metals, and energy-intensive conditions. In this context, the search for alternative and milder methodologies has become increasingly important for the expansion of research in the field of organosulfur compounds. One promising approach that has gained attention is the use of inorganic salts as reaction catalysts; among these, ammonium iodide stands out due to its low toxicity, high efficiency under mild conditions, and accessible cost, as well as the absence of heavy metals, which makes it a greener option for synthetic applications. Accordingly, the present work describes an environmentally friendly protocol for the selective oxidation of thiols to disulfides, catalyzed by ammonium iodide (20 mol%), using dimethyl sulfoxide (DMSO) as the solvent (100 µL) and a reaction time of 5 minutes at room temperature. This methodology enabled the synthesis of a broad scope of disulfides with good to excellent yields. The scalability of the reaction was also demonstrated, supporting its potential industrial applicability. Thus, this work addresses the need for innovative methods that combine efficiency, low environmental impact, and industrial viability for the green synthesis of disulfides.