Estimulação adrenérgica causada pela administração de isoproterenol induz disfunção metabólica e remodelamento pancreático em ratos Wistar
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2022-08-30
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Universidade Federal de Goiás
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Isoproterenol is a drug commonly used for the treatment of bradycardia, heart block,
bronchospasm during anesthesia and rarely for asthma. It is a non-selective β-adrenergic
agonist analogue of epinephrine, for this reason it promotes positive inotropic and
chronotropic effects in cardiac tissue, being used as an experimental model for the study of
cardiac alterations. It is known that the adrenergic stimulation caused by the administration of
isoproterenol induces cardiac remodeling, usually through pathways mainly related to redox
status and inflammatory cytokines. However, little is known about the metabolic damage of
this model. Thus, this study aims to evaluate the effects of isoproterenol administration on
metabolic and morphological parameters. Adult Wistar rats (50-60 days old; weighing 200-
250g) were allocated into two experimental groups: control rats (CO) that received vehicle
(150 mM NaCl, 0.1ml/kg/day; i.p.), and rats that received received injections of isoproterenol
(ISO; 1 mg/kg/day; i.p.) for 7 consecutive days. After the treatment period, the animals were
submitted to in vivo tests and later euthanized for sample collection. The animals in the ISO
group did not show a significant difference in body mass compared to the CO animals. On the
other hand, ISO animals showed increased brown adipose tissue mass and brown adipose
area. Furthermore, the administration of isoproterenol promoted pancreatic remodeling, with
an increase in the area of pancreatic islets and interstitial fibrosis. In short, in addition to
cardiac changes, the adrenergic overload induced by isoproterenol administration was also
able to promote significant morphological changes in brown adipose tissue and pancreas,
these changes may be linked to changes in the heart and in other systems, thus, the study
Integrated physiological training is fundamental for a better understanding of the exacerbated
stimulation of β-adrenergic receptors.
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CASTRO, A. G. Estimulação adrenérgica causada pela administração de isoproterenol induz disfunção metabólica e remodelamento pancreático em ratos Wistar. 2022. 52 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Goiás, Goiânia, 2022.