Desenvolvimento e caracterização de microemulsão à base de óleo de sucupira (P. emarginatus Vog. Fabaceae) e avaliação da atividade antiinflamatória tópica
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2012-02-27
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Universidade Federal de Goiás
Resumo
Pterodon emarginatus, popularly known as Sucupira Branca is a native species
found in the Brazilian Savannahs in states of Goiás, Minas Gerais, São Paulo, Mato
Grosso do Sul. Several studies have confirmed their therapeutic activities as antiinflammatory,
antinociceptive, analgesic, antimicrobial, among others. The aim of this
study was to develop a microemulsion with topical anti-inflammatory activity from the
fixed oil obtained by cold pressing of the fruits of sucupira and additionally evaluate
the topical anti-inflammatory activity using the same model of ear edema induced by
croton oil. Initially, we made the physical-chemical and chemical composition of
vegetable raw material. Using gas chromatography coupled with mass detector was
possible to identify the presence of sesquiterpenes such as -caryophyllene and -
humulene, with known anti-inflammatory pharmacological activity. The calculation of
HLB value required by the oil and tests for determining the surfactant system has
enabled the formulation of a microemulsion system using the surfactant/cosurfactant
Ultramona® R-540/propyleneglycol, oil sucupira and water proportions 15:10:75
respectively. Stability tests have shown that the formulation when stored in the
refrigerator (5±2°C) or room temperature (25±2°C) w ere stable for 30 days with no
significant alterations in their physical and chemical parameters. The antiinflammatory
activity of oil and formulating show statistical significance when
compared to the respective negative controls with p <0.001 for both. The
microemulsion presented an effective dosage form for this activity showing great
potential for increasing the permeability of the skin oil sucupira confirming the
possibility of obtaining a topical herbal medicine with anti-inflammatory action.
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PASCOA, Henrique. Desenvolvimento e caracterização de microemulsão à base de óleo de sucupira (P. emarginatus Vog. Fabaceae) e avaliação da atividade antiinflamatória tópica. 2012. 88 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2012.