Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas
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Data
2009-12-15
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Universidade Federal de Goiás
Resumo
Non-ionic surfactant vesicles (niosomes) and cyclodextrins (CDs) are able to modify
physical-chemical properties of incorporated drugs. One of the major challenges for
the topical administration of retinoids, such as isotretinoin (31cisRA), is the stability of
these compounds in formulations capable of reducing their toxicity during the
treatment. The purpose of this research was to develop vesicular carries capable to
transport and deliver isotretinoin for topical application during acne treatment. The
niosomes were obtained from Bryj®30:Cholesterol:DCP (50:25:10) by the film
hydration method. The HP CDs:isotretinoin complex was obtained by agitation for 8
days in phosphate buffer pH 7.4. The vesicles were characterized and it was
possible to encounter a large amount of morphological varieties, flexible structures
and fluid membrane, after inclusion of free isotretinoin. The fluidness of the
membrane that contains isotretinoin allowed leaking of the drug when in
concentration above 5 mM. The HP CDs:Isotretinoin (20:1) increased the vesicle
size considerably, also allowing drug leaking. The systems developed presented
themselves as potential carries of isotretinoin for topical application and played the
roll of drug delivery system,
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RODOVALHO, Luciana Ferreira Fonseca. Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas. 2009. 81 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2009.