Estudo fitoquímico e avaliações da toxicidade aguda e atividades biológicas da raiz do vetiver (Vetiveria zizanioides L. Nash) Poaceae
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Data
2009-03-23
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Universidade Federal de Goiás
Resumo
The use of medicinal plants in controlling the diseases has shown its
potential for the discovery of new medicines. Among the plant species used in
the Hospital de Medicina Alternativa (HMA / SES-GO) highlights the vetiver
(Vetiveria zizanioides L. Nash), an aromatic plant of the family Poaceae, used
as a mild anti-hypertensive and diuretic. In this work it was investigated the
chemical composition of the hydroalcoholic extract of vetiver, the freeze-dried
aqueous extract and the essential oil from the roots of V. zizanioides. In the
hydroalcoholic extract were found terpenoids compounds and / or saponins,
flavonoids and phenolic acid. In the freeze-dried aqueous extract was observed
the presence of flavonoids and phenols. In the essential oil 38 compounds were
identified, and khusimol, palustrol, khusimona, zizanona and epi-α-vetivona
were the major constituents. In the assessment of the acute toxicity of the
hydroalcoholic extract and the freeze-dried aqueous extract of root of V.
zizanioides, it was concluded that these extracts showed no toxicity at a dose of
2000 mg / kg. The freeze-dried aqueous extract of the roots of V. zizainoides
showed no statistically significant diuretic action in the doses tested. In the
investigation of antimicrobial activity, the essential oil of the root of V.
zizanioides showed potent activity to inhibiting the growth of Staphylococcus
aureus with MIC of 0.15 mg / mL. The crude ethanolic extract showed an
antimicrobial activity with MIC of 0.19 mg / mL for Bacillus cereus and
Micrococcus roseus and 0.39 mg / mL for Micrococcus luteus, S. aureus and
Bacillus subtilis. The hexane fraction showed stronger antimicrobial activity
against strains of M. luteus, M. roseus, S. aureus and B. cereus. This study
could prove that the essential oil, the crude ethanol extract and hexane fraction
from roots of V. zizanioides showed antimicrobial potential.
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Citação
BARROS, Gilvana Cristina de. Phytochemical study and evaluation of agude toxicity and biologival activities of the roots Vetiver (Vetiveria zizanioides L. Nash)
Poaceae. 2009. 100 f. Dissertação (Mestrado em Ciências da Saúde - Farmácia) - Universidade Federal de Goiás, Goiânia, 2009.