Síntese e Caracterização de Novos Complexos de Ru(III) com Ligantes Nitrogenados Heterocíclicos e Potencial Atividade Antitumoral
Nenhuma Miniatura disponível
Data
2017-05-31
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
Cancer is a genetic disease caused by mutations in the DNA that can develop
in any part of the body. Its treatment follows different approaches, including
chemotherapy, which can be quite aggressive. Ruthenium compounds
associated with heterocyclic nitrogen ligands have been well studied because
of their promising antitumor activity, some of them already present good results
and are in the preclinical phase, such as [H-Imidazole]
[trans-RuCl4(imidazole)(DMSO)] (NAMI-A) and
[H-indazole][trans-RuCl4(indazole)2] (KP1019). In this work, six Ru
coordination compounds were synthesized, four of them being unpublished,
with heterocyclic nitrogenous ligands 2-(1H-pyrazole)-1-pyridine (L1
),
(1-(pyridine-2)-1H-pyrazole-4-il)methanol (L2
),
ethyl-4-((1-(pyridine-2)-1H-pyrazole-4-il)methyl)pipyrazine-1-carboxylate (L3
)
e 1-(4-((1-(pyridine-2-)-1H-pyrazole-4-)methil)pipyrazine-1-)etanone (L4
)
which are believed to have potential antitumor activity. The compounds were
synthesized by reaction under reflux and characterized by: infrared and Uv/Vis
spectroscopy, 1H nuclear magnetic resonance spectroscopy, elemental
analysis (CHNS), single crystal x-ray diffraction and cyclic voltammetry. The
binders used have the same target nucleus for coordination consisting of a
pyridine ring and a pyrazole ring. The ligands showed two different modes of
coordination to the metal, a bidentate, forming a chelate with the metal, occurs
with the ligands L
1 and L
2 and another monodentate, where the ligand
coordinates with the metal only by the nitrogen atom of the pyrazole ring, the
which occurs with ligands L
3 and L
4
.
Descrição
Palavras-chave
Rutênio , NAMI-A , KP1019 , Antitumoral , Compostos Nitrogenados , Ruthenium , NAMI-A , KP1019 , Antitumor , Nitrogen Compounds
Citação
NORONHA, L. F. Síntese e Caracterização de Novos Complexos de Ru(III) com Ligantes Nitrogenados Heterocíclicos e Potencial Atividade Antitumoral. 2017. 72 f. Dissertação (Mestrado em Química) - Instituto de Química, Universidade Federal de Goiás, Goiânia, 2017.