Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15745
Tipo do documento: Artigo
Título: Antiproliferative activity and constituents of aspidosperma macrocarpon (Apocynaceae) laves
Autor: Bannwart, Geanderson
Oliveira, Cecilia Maria Alves de
Kato, Lucilia
Silva, Cleuza Conceição da
Ruiz, Ana Lúcia Tasca Gois
Carvalho, João Ernesto de
Santin, Silvana Maria de Oliveira
Abstract: Aspidosperma macrocarpon belongs to the family Apocynaceae and is endemic to Americas and mainly found from Mexico to Argentina. It is known in Brazil as “guatambu” or “peroba”. Crude extracts and their fractions from leaves were assayed against human cancer cells lines: glioma (U251), melanoma (UACC- 62), mammary (MCF-7), ovarian expressing the multidrug resistance phenotype (NCI-ADR/RES), lung (NCIH460), prostate (PC-3), kidney (786-0), ovarian (OVCAR-3), colon (HT-29) and leukemia (K-562). The crude extract (EAM), hexane (HA) and chloroform (CA) fractions were the most active fractions against K-562 with GI50 values low than 1 μg/mL. Also, CA was moderate active against OVCAR-3 and NCI-ADR/RES cells lines. This phytochemical study allowed to identify the known kopsanone, kopsinine, ursolic acid, rutin, 5-Ocaffeoylquinic acid, and 3,5-O-dicaffeoylquinic acid. The kopsanone was also evaluated against human cancer cell lines and showed activity to the U251 and K-562 cell lines, with GI50 values of 20.6 μg/mL and 8.7 μg/mL, respectively.
Palavras-chave: Aspidosperma macrocarpon
Antiproliferative activity
Alkaloids
País: Outros
Unidade acadêmica: Instituto de Química - IQ (RG)
Citação: BANNWART, Geanderson et al. Antiproliferative activity and constituents of aspidosperma macrocarpon (Apocynaceae) laves. Records of Natural Products, Gebze, v. 7, n. 2, p. 137-140, 2013.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/15745
Data de publicação: 2013
Aparece nas coleções:IQ - Artigos publicados em periódicos

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