Antiproliferative activity and constituents of aspidosperma macrocarpon (Apocynaceae) laves
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Data
2013
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Resumo
Aspidosperma macrocarpon belongs to the family Apocynaceae and is endemic to Americas and
mainly found from Mexico to Argentina. It is known in Brazil as “guatambu” or “peroba”. Crude extracts and
their fractions from leaves were assayed against human cancer cells lines: glioma (U251), melanoma (UACC-
62), mammary (MCF-7), ovarian expressing the multidrug resistance phenotype (NCI-ADR/RES), lung (NCIH460),
prostate (PC-3), kidney (786-0), ovarian (OVCAR-3), colon (HT-29) and leukemia (K-562). The crude
extract (EAM), hexane (HA) and chloroform (CA) fractions were the most active fractions against K-562 with
GI50 values low than 1 μg/mL. Also, CA was moderate active against OVCAR-3 and NCI-ADR/RES cells
lines. This phytochemical study allowed to identify the known kopsanone, kopsinine, ursolic acid, rutin, 5-Ocaffeoylquinic
acid, and 3,5-O-dicaffeoylquinic acid. The kopsanone was also evaluated against human cancer
cell lines and showed activity to the U251 and K-562 cell lines, with GI50 values of 20.6 μg/mL and 8.7 μg/mL,
respectively.
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Aspidosperma macrocarpon, Antiproliferative activity, Alkaloids
Citação
BANNWART, Geanderson et al. Antiproliferative activity and constituents of aspidosperma macrocarpon (Apocynaceae) laves. Records of Natural Products, Gebze, v. 7, n. 2, p. 137-140, 2013.