IQ - Artigos publicados em periódicos
URI Permanente para esta coleção
Navegar
Navegando IQ - Artigos publicados em periódicos por Autor "Alcântara, Antônio Flávio de Carvalho"
Agora exibindo 1 - 1 de 1
Resultados por página
Opções de Ordenação
Item Natural organic acid as green catalyst for xanthenones synthesis: methodology, mechanism and calcium channel blocking activity(2017) Diniz , Bruna Silva Terra; Blandón Osorio, Aura María; Oliveira, Aline de; Mouro, Andressa Pereira; Araújo, Natália Ferreira de; Silva, Cameron Capeletti da; Martins, Felipe Terra; Vieira , Luciene Bruno; Bonaventura, Daniella; Abreu, Heitor Avelino de; Alcântara, Antônio Flávio de Carvalho; Fátima, Ângelo deXanthenones were synthesized via one-pot tricomponent reaction, under solvent-free conditions, using aldehydes, phenolic and cyclic 1,3-dicarbonyl compounds. Natural organic acids (NOAs), compounds present in many living metabolisms, were used as potential green catalysts. NOA are considered to be more eco-friendly and user-friendly alternative to traditional methodologies. Optimization studies showed that oxalic acid was the best NOA catalyst for such reaction furnishing the xanthenones with up to 93% of yield. Theoretical calculations were performed to evaluate this reaction mechanism and regioselectivity. The results showed that the regiospecificity of this three-component reaction is kinetically and thermodynamically controlled by the addition of b-naphthol C2, instead of C10, to the aldehyde. Our results also disclosed two xanthenones as novel calcium channels blockers. Eco-friendly reaction conditions, easy workup procedure, short reaction times and good yields are some of the advantages of our methodology.