ICB - Artigos publicados em periódicos

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Nitric oxide in oral homeostasis: endogenous production and microbiota contribution
(2025) Silva, Amanda Barreira; Carvalho, Pedro Ivo de; Guillo, Lidia Andreu
Nitric oxide plays a crucial role in oral homeostasis, yet its relevance remains underexplored. This communication aims to describe the dual role of nitric oxide in oral health by examining its endogenous production by adult odontoblasts and its generation by nitrate-reducing bacteria in the oral microbiota. Additionally, it presents therapeutic approaches to modulate nitric oxide levels, including nitric oxide-releasing biomaterials and dietary interventions such as prebiotics and probiotics. Recent findings confirm the constitutive expression of nitric oxide synthase in healthy adult odontoblasts, indicating a continuous role in pulp health maintenance. Simultaneously, nitrate-reducing bacteria contribute to oral balance by metabolizing dietary nitrates into nitric oxide. These mechanisms support nitric oxide as a key modulator of oral homeostasis. Understanding and leveraging these pathways may provide innovative strategies for oral disease prevention and tissue regeneration, reinforcing the importance of nitric oxide-targeted therapies in dentistry.
Atividade antiproliferativa do composto bioativo de Silybum marianum em linhagem celular de melanoma humano com mutação BRAF: potencial para reposicionamento terapêutico
(2025) Cardoso, Cléver Gomes; Guillo, Lidia Andreu
This study investigated the in vitro antiproliferative potential of Silibinin on human melanoma cells with a BRAF gene mutation. Cell viability was assessed through incubation with different concentrations (41, 104, 207, and 518 μM) for 48 hours, using the MTT assay (3-(4,5-dimethylthiazol-2 -yl)-2,5-diphenyltetrazolium bromide), which involves the reduction of the tetrazolium salt. The inhibitory concentration (IC50) was determined to be 240 μM. Bright-field microscopy revealed loss of cell adhesion to the substrate, a characteristic feature of cell death by apoptosis, across the tested doses. These results highlight the need for further studies to elucidate the mechanism of action and confirm its clinical efficacy.
Wound healing and anti-inflammatory effects of LAA, the N-acetyl-d-galactosamine-binding lectin from seeds of Luetzelburgia auriculata (Allemão) ducke
(2025) Batista, Karla Lilian Rodrigues; Silva, Lucas dos Santos; Silva, Izadora Souza Soeiro; Paiva, Miria Yasmim Miranda; Santos, João Lucas Sales; Sousa, Carlos Eduardo Morais de; Castelo Branco, Simeone Júlio dos Santos; Paiva, Felipe Eduardo Alves de; Roma, Renato Rodrigues; Cardoso, Cléver Gomes
Cutaneous wounds represent a significant health concern, and effective treatment strategies are crucial for optimal healing. This study investigates the therapeutic potential of Luetzelburgia auriculata lectin (LAA), a plant-derived protein, in accelerating wound closure. Excisional wounds were created on the backs of mice, which were subsequently treated topically with LAA solutions at two concentrations (100 µg/mL and 200 µg/mL) or saline control. Wound healing was assessed through clinical observations, including wound area measurement and inflammatory score, as well as histopathological analysis and measurement of inflammatory cytokines. LAA significantly accelerated wound closure, reduced inflammation, and promoted tissue regeneration. Histological analysis revealed enhanced re-epithelialization, increased fibroblast proliferation, and improved collagen deposition in LAA-treated wounds compared with the control group. Furthermore, LAA treatment significantly reduced the levels of proinflammatory cytokines in wound tissues (interleukin-6, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1). These findings suggest that LAA exerts its beneficial effects through a multifaceted mechanism, likely involving anti-inflammatory properties and stimulation of cellular processes crucial for tissue repair. This study provides preliminary evidence for the therapeutic potential of LAA in wound healing and warrants further investigation into its underlying mechanisms and clinical applications.
Cratylia mollis lectin reduces inflammatory burden induced by multidrug-resistant Staphylococcus aureus in diabetic wounds
(2025) Silva, Lucas dos Santos; Castelo Branco, Simeone Júlio dos Santos; Silva, Izadora Souza Soeiro; Paiva, Miria Yasmim Miranda; Vila Nova, Beatriz Gomes; Lima, Carlos Emanuel de Matos Chaves; Oliveira, Weslley Felix de; Paiva, Felipe Eduardo Alves de; Paiva, Patrícia Maria Guedes; Monteiro, Andrea de Souza; Cardoso, Cléver Gomes
In diabetes, tissue repair is impaired, increasing susceptibility to Staphylococcus aureus infections, a pathogen commonly found in wounds. The emergence of S. aureus strains that are highly resistant to antimicrobial agents highlights the urgent need for alternative therapeutic options. One promising candidate is Cramoll (Cratylia mollis seed lectin), known for its immunomodulatory, mitogenic, and healing properties. However, its efficacy in infected diabetic wounds remains unexplored. This study evaluated the effects of topical Cramoll treatment on diabetic wounds infected by S. aureus. Diabetic Swiss mice (induced by streptozotocin) were subjected to an 8-mm wound on the back and subsequently infected with a suspension of multidrug-resistant S. aureus. During the treatment period, the wounds were clinically evaluated for inflammation and the area of injury. After seven days, samples were collected from the wounds to quantify the bacterial load and histopathological and immunological analyses. Wounds infected by S. aureus exhibited more pronounced areas and severity indices, which were significantly reduced by Cramoll treatment (p < 0.05). Histopathological analysis revealed a reduction in inflammatory cells and an increase in revascularization with Cramoll treatment (p < 0.05). Cramoll also promoted greater collagen production compared to controls (p < 0.05). Furthermore, Cramoll treatment significantly reduced the S. aureus load in wounds (p < 0.0001), decreased TNF-α and IL-6 levels in infected wounds, and increased ERK pathway activation (p < 0.05). In conclusion, Cramoll lectin improves the healing of diabetic wounds, and these results contribute to the understanding of Cramoll healing mechanisms, reinforcing its potential as a healing agent in various clinical conditions.
Association of I/D polymorphism in the ACE gene and the susceptibility of patients to diabetic neuropathy
(2025) Menezes, Georgia Silva; Paiva, Pedro Luiz de; Santos, Kamilla de Faria; Reis, Angela Adamski da Silva; Santos, Rodrigo da Silva
We conducted a systematic review and meta-analysis to evaluate the association between polymorphisms in the ACE and ACE2 genes and the development of diabetic neuropathy (DN). Methods: We searched six databases (NCBI/PubMed, MEDLINE, Cochrane Library, Virtual Health Library, Scielo, and Embase) as well as grey literature (Google Scholar and citations). Two independent reviewers selected the articles according to predefined inclusion and exclusion criteria. Results: The systematic literature search identified 114 records across the databases. At the end of the selection process, 5 studies were included in the qualitative analysis, and 4 studies were included in the quantitative analysis. All included studies were case-control studies conducted in Iraqi, Pakistani, and Turkish populations. Conclusion: According to the meta-analysis, the ID+DD genotypes of the ACE gene I/D polymorphism are associated with an increased risk of developing DN (OR = 1.43, CI = 1.01–2.03, p = 0.0464). Our analysis also suggests that the D allele is a risk marker for DN (OR = 1.42, CI = 1.19–1.68, p < 0.0001), with similar findings previously reported. Further observational studies in diverse populations are needed to confirm this association.
Clinical-functional assessment of patients with aortic stenosis undergoing transcatheter aortic valve implantation
(2025) Sousa, Wátila de Moura; Gardenghi, Giulliano; Fernandes, Fernando Henrique; Prudente, Maurício Lopes; Oliveira, Jordana Campos Martins de; Souza Filho, Luiz Fernando Martins de; Rebelo, Ana Cristina Silva
Background: transcatheter aortic valve implantation (TAVI) is known to enhance valve structure and function in old adults with aortic stenosis. Aim: to evaluate the clinical and functional characteristics of 40 patients (mean age 79 ± 5 years) undergoing transfemoral TAVI during their hospital stay. Methods: this cross-sectional study. Data on mean aortic valve area, Society of Thoracic Surgeons (STS) morbidity and mortality score, echocardiographic measurements, peak cough flow (PCF), handgrip strength (HGS), 5-meter walk test (5MWT), and 6-minute walk test (6MWT) were collected at three time points: pre-TAVI, post-TAVI, and at hospital discharge. Results: results showed reductions in peripheral oxygen saturation (p = 0.004), peak aortic gradient (p = 0.001), and mean aortic gradient post-TAVI (p = 0.001), along with increased left ventricular ejection fraction (p = 0.001) and prolonged 5MWT completion time on the first postoperative day (p =0.003). Moderate negative correlations were observed between the European System for Cardiac Operative Risk Evaluation II score (EuroSCORE II) score and PCF (r = -0.329; p = 0.041), STS with PCF (r = -0.473; p = 0.002), and STS with 6MWT at discharge (r = -0.324; p = 0.044), as well as STS with HGS pre-TAVI (r = -0.363; p = 0.041). Conclusion: changes in clinical and functional variables, the increase in 5MWT time suggests a deterioration in frailty in the population. Implementing pre- and postoperative rehabilitation programs may help mitigate functional losses in this clinically vulnerable population.
In silico evaluation of effect and molecular modeling of snps in genes related to amyotrophic lateral sclerosis
(2025) Roza, Gustavo Ronconi Roza; Costa, Caroline Christine Pincela da; Lima, Nayane Soares de; Reis, Angela Adamski da Silva; Santos, Rodrigo da Silva
Background: Amyotrophic lateral sclerosis is a systemic, complex, multifactorial, and fatal neurodegenerative disease with various factors involved in its etiology. This study aimed to understand the effects of SNPs in the MTHFR, MTR, SLC19A1, and VAPB genes on protein functionality and structure and their influence on ALS susceptibility. Methods: The dbSNP and ClinVar databases were used for SNP data annotation, while UniProt and PDB provided protein sequences. We performed functional and structural predictions of SNPs using PolyPhen-2 and SNAP2. We modeled mutant proteins using AlphaFold 2 and visualized them in PyMOL to compare native and mutant forms. Results: Our results identified SNP rs74315431 as pathogenic, inducing structural and functional changes and exhibiting visible alterations in the three-dimensional structure. Although predicted as non-pathogenic, SNPs rs1801131, rs1805087, and rs1051266 caused protein structural alterations, a finding confirmed by three-dimensional visualization. SNP rs1801133 diverged from the others, being predicted as pathogenic but without causing changes in protein structure or function. Conclusions: Our study found a strong correlation between SNAP2-predicted alterations and those predicted by AlphaFold 2, whereas PolyPhen-2 results did not directly correlate with three-dimensional structure changes.
Genetic variants and heat shock proteins: unraveling their interplay in neurodegenerative sclerosis: a comprehensive review
(2025) Bittar, Jacqueline Soares Barros; Costa, Caroline Christine Pincela da; Lima, Nayane Soares de; Reis, Angela Adamski da Silva; Santos, Rodrigo da Silva
Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS) are multifactorial and progressive neurodegenerative diseases (ND), which cause a functional capacity decline. Both diseases etiology remains unclear. They may have a hereditary genetic architecture, but they can also be due to a combination of genetic and environmental factors. Heat shock proteins (HSPs) play a crucial role in protein quality control, avoiding protein dysfunction and, consequently, cell apoptosis, which are well-known pathogenic mechanisms of ND. There are studies about chaperones physiology. However, research on their pathophysiology is scarce. Especially when it comes to their associated dysfunctions with Single nucleotide variants (SNV) on HSPs in ND. Thus, this review aimed to examine the role of genetic variants in genes encoding HSPs and their contribution to the pathophysiology of these sclerosis. We performed a qualitative and descriptive literature review, searching by the indexed terms “amyotrophic lateral sclerosis,” “genetic variants,” “heat shock proteins,” “Hsp40”, “Hsp70”, Hsp90”, “DNAJC7”, “multiple sclerosis,” “neurodegenerative diseases,” “protein quality control”, and “SNV” in the PubMed/NCBI, EMBASE and SciELo databases. Results described by a qualitative synthesis of the most significant studies. Despite the existence of studies with genetic variants in HSPs in patients with ND, we realize in this review the need for more specific research on this topic to demonstrate a significance as to the responsibility for deleterious effects in the modification in genes HSPs linked to sclerosis.
Association of genetic variants with the progression of COVID-19 symptoms in diabetic patients: a systematic review and in silico protein interaction analysis
(2025) Silveira, Luciana Carvalho; Santos, Kamilla de Faria; Assunção, Leandro do Prado; Reis, Angela Adamski da Silva
Diabetes mellitus is a global public health issue and, at the onset of the COVID-19 pandemic, was identified as a risk factor associated with high morbidity and mortality in cases of acute respiratory infection caused by the SARSCoV-2 coronavirus. This study investigated genetic variants in diabetic patients with COVID-19 through a systematic analysis of the PubMed/NCBI, EMBASE, Web of Science, SCOPUS, and Virtual Health Library databases, with the protocol registered on the PROSPERO platform (registration number CRD42020181311). Fifteen genetic variants were associated with five specific genes in symptomatic diabetic patients with COVID-19. Inheritance models, diabetic individuals carrying the heterozygous genotype TC (VDR rs4516035) showed ~10–15-fold higher odds of symptomatic COVID-19. Protein-protein interaction (PPI) analysis showed that the proteins ACE, ACE2, IL-6, and IL-17 exhibited strong predicted interactions with each other, as well as with insulin and the TMPRSS2 protease. Limitations include small number of eligible studies, heterogeneity in populations and outcome definitions. These preliminary findings highlight the need for further studies to understand better the relationship between the identified genetic variants and the progression of COVID-19 in diabetic patients.
Eficácia e segurança do heat moisture exchangers e adesivo de fixação para o tratamento de pacientes submetidos à ventilação mecânica invasiva: revisão rápida de evidências
(2025) Souza Filho, Luiz Fernando Martins de; Morais, Letícia de Araújo; Lima, Vinicius de Almeida; Rebelo, Ana Cristina Silva; Morais, Naiane Silva
This rapid evidence review aimed to evaluate the effectiveness and safety of Heat Moisture Exchangers (HME) and fixing adhesives in the treatment of patients undergoing invasive mechanical ventilation, with a focus on tracheostomized and/or laryngectomized patients. The analysis was based on a high-quality systematic review (SR) assessed by the AMSTAR-2 tool and clinical trials that addressed the use of these devices in different clinical contexts. The results indicated that HME filters are a viable alterna tive for humidifying and heating inspired gases, with efficacy comparable to heated humidification (HH) in outcomes such as airway obstruction, pneumonia, and mortality. However, the overall quality of the evidence was considered low, highlighting the need for further research, especially in pediatric and neonatal populations. The safety of the devices was confirmed, with a low incidence of serious adverse events. It is concluded that HME filters and fixing adhesives are safe and effective, but treatment individualization and further studies are essential to guide clinical practice.
Adjuvant radiotherapy for intermediate-risk early-stage cervical cancer post radical hysterectomy: a systematic review and meta-analysis
(2025) Silva, Pedro Henrique Costa Matos da; Molino, Gabriela Oliveira Gonçalves; Dias, Mairla Marina Ferreira; Pereira, Ana Gabriela Alves; Pimenta, Nicole dos Santos; Cavalcante, Deivyd Vieira Silva; Santos, Ana Clara Felix de Farias; Ferreira, Sarah Hasimyan; Santos, Rodrigo da Silva; Reis, Angela Adamski da Silva
The risk of recurrence of early-stage cervical cancer (CC) is asso- ciated with prognostic factors such as tumor size, lymphovascular space invasion (LVSI), and deep stromal invasion (DSI). However, the adjuvant pelvic radiotherapy (RT) fol- lowing surgery to reduce the risk of recurrence in “intermediate risk” remains controver- sial. This study aims to evaluate the role of adjuvant RT in the recurrence and identify prognostic factors. Methods: A systematic search of PubMed, Embase, and Cochrane databases was performed to identify studies comparing adjuvant RT versus no adjuvant treatment in early-stage CC patients with intermediate-risk factors defined by GOG-92 criteria. Outcomes were recurrence, local recurrence, death, 5-year overall survival (5y-OS), and 5-year disease-free survival (5y-DFS). Tumor size ≥ 4 cm, LVSI, and DSI were also evaluated as prognostic factors for recurrence. Statistical analysis was performed using Review Manager 7.2.0. Heterogeneity was assessed with I2 statistics. Results: A total of 1504 patients from nine studies were included; only one study was a randomized con- trolled trial, while the others were retrospective cohorts. Adjuvant RT was used to treat 781 patients (52%). Median follow-up ranged from 48 to 120 months. Recurrence (OR 0.75; 95% CI 0.38–1.46; p = 0.39), local recurrence (OR 0.73; 95% CI 0.44–1.20; p = 0.22), death (OR 0.97; 95% CI 0.52–1.80; p = 0.91), 5y-OS (OR 1.22; 95% CI 0.36–4.18; p = 0.75), and 5y-DFS (OR 0.78; 95% CI 0.42–1.43 p = 0.42) revealed no statistically significant differences between adjuvant RT and observation groups. TS ≥ 4 cm was an independent prognostic risk factor for recurrence (HR 1.83; 95% CI 1.12–2.97; p = 0.02). Conclusions: Our findings suggest that adjuvant RT does not reduce recurrence risk in early-stage cervical cancer. Consider TS ≥ 4 cm as a significant prognostic factor for recurrence. Adjuvant RT in intermediate-risk patients should be considered with caution due the lack of significant improvement in recurrence until the CERVANTES and GOG-0263 trial results become available.
Abiotic factors influencing anuran occupation of Neotropical Brazilian caves
(2025) Sperandei, Vinícius da Fontoura; Vaz-Silva, Wilian; Tejerina-Garro, Francisco Leonardo
Despite increasing research on the Neotropical underground environment, anurans remain poorly understood in this habitat. It was analyzed scientific literature records of anurans in Brazilian natural caves and performed a redundancy analysis (RDA) to identify the environmental, taxonomic, geographic, geological and land-use variables that influence their cave occupancy. It was examined a total of 247 literature records, encompassing 83 species/morphospecies, which revealed distinct cave-dwelling tendencies. Some anuran species occupy caves at altitudes between 5 to 21 meters above sea level (m asl), in areas characterized by rocky outcrops and grassland. Others are associated with caves surrounded by forest, savanna, pasture or mosaic of agriculture and pasture. A third group is linked to caves with varying lithologies. These findings highlight specific ecological scenarios for anuran occurrence in Neotropical caves. Conserving cave-dwelling anurans in the Neotropical region depends on understanding the factors influencing their subterranean occupancy. Preserving native vegetation and maintaining undisturbed landscapes are essential. This will safeguard these sensitive species and reinforce their role as bioindicators of ecological impacts in cave environments.
Accumulation and interactions of trace elements in tadpoles of Dendropsophus minutus(Peters, 1872) (Anura: Hylidae) in natural and soybean monoculture areas from Central Brazil
(2025) Gerolineto-Alves, Igor; Tejerina-Garro, Francisco Leonardo; Silva Júnior, Nelson Jorge da; Borges, Leonardo Luiz; Feitosa, Darlan Tavares; Pires, Matheus Godoy; Santos, Fernanda Sousa; Vaz-Silva, Wilian
The contamination of natural ecosystems by trace elements represents a growing environmental concern, particularly in regions under agricultural expansion. In the Brazilian Cerrado, soybean monocultures contribute to soil and water contamination through agrochemicals containing potentially toxic elements. Amphibians, especially tadpoles, are highly sensitive to such disturbances and are thus recognized as reliable bioindicators of environmental quality. This study investigated the accumulation and interaction of eight metals (As, Ba, Cd, Cr, Cu, Hg, Pb, and Zn) in Dendropsophus minutustadpoles collected from soybean cultivation areas and a preserved site on Cerrado biome, in Cezarina municipality, State of Goiás, Central Brazil. A total of 20 tadpoles were collected, equally divided between case and control areas, and analysed after the acid digestion of the whole tadpole, through inductively coupled plasma optical emission spectrometry (ICPOES). Tadpoles from soybean areas exhibited significantly higher concentrations of As, Ba, Cd, Cr, Cu, Pb, and Zn compared with those from the preserved site, while Hg did not differ significantly, suggesting low environmental mobility or absence in local inputs. The most critical increases were detected for Cd, Cu, and Pb, with values exceeding those of the control site by 6378%, 13842%, and 1108%, respectively. Statistical analyses revealed strong positive correlations, notably Pb with Ba, Cd, Cr, and Cu, in addition to interactions involving Cd–Cr, Cd–Cu, Cr–Cu, and Zn–As. These associations suggest synergistic accumulation, with potential to intensify physiological stress in amphibians, including oxidative damage and developmental impairments.
Selection of priority areas for implementing effective mitigation actions on avifauna in power lines installed in southeastern Brazil
(2025) Vaz-Silva, Wilian; Andrade, Sheila Pereira de; Souza, Wesley Dias de; Silva, Emivânia Cavalcante da; Veríssimo, Pablo Henrique Rodrigues; Severino, Laura de Freitas; Garcia, Gisele; Paro, Paulo Renato Pereira
The continuous growth in the energy sector requires changes in the landscape that include the installa-tion of new transmission and distribution lines. In addition to the impacts arising from the fragmentation and loss of their habitats, birds are also exposed to the risk of death from collision and electrocution with these structures. To minimize this risk, back up the adoption of mitigation measures, and prioritize areas of greater susceptibility to these effects, we present a method for planning and select-ing areas based on data from potentially protected bird communities collected in field. Samplings were carried out along two high-voltage transmission lines already imple-mented in the southeastern region of Brazil along the 18 monitored stretches. The observations of bird f light behav-ior and use of airspace were evaluated at the taxonomic level of families, and we applied chi-square tests (α = 0.05) for these two risk variables. The results showed seven areas with potential for prioritizing mitigation actions, show-ing that the sampling design was effective and can apply to similar projects.
Indicadores de saúde ambiental e o processamento agroindustrial da cana-de-açúcar no Estado de Goiás, CO Brasil
(2025) Batista, Nayala Etina Ferreira dos Santos; Tejerina-Garro, Francisco Leonardo; Vaz-Silva, Wilian
Sugarcane is cultivated throughout the world as the main agricultural crop, due to its essential raw material for the production of sugar, ethanol and other derived products. The State of Goiás is the second largest producer of sugar and alcohol in Brazil. Although the cultivation of sugar cane is considered essential for the economic development of the state, however, it puts the health of the environment, human beings, and animals at risk. The expansion of this cultivation in Goiás can result in the loss of natural habitats, causing impacts on biodiversity, soil, and water resources. Furthermore, the sugarcane agro-industrial process is associated with the intensive consumption of agrochemicals. Therefore, it is necessary to survey the environmental health of the municipalities of Goiás where they do or do not house sugarcane plants. Since, environmental health always seeks to correlate the balance of ecosystems with the quality of life of local populations. To do this, we will use the Driving Force, Pressure, Situation, Exposure, Effect, and Action (FPSEEA) model, a multidimensional matrix used to investigate the factors involved in the healthdisease process at the interface between health and the environment. The objective of the study was to analyze environmental health indicators in municipalities that have a sugarcane production chain in the State of Goiás. Therefore, surveys were conducted in the DATASUS and Atlas Brasil databases considering some environmental health indicators of municipalities in Goiás with the presence and absence of sugarcane mills. The information from the indicators was used to create the FPSEEA model. This collected information was organized in a data matrix subjected to descriptive statistical analysis with the help of the Excel® program. According to the results obtained, it was possible to observe a significant link between economic, health, and sanitation indicators, with the causes of morbidity (≤ 2 years) and mortality (≤ 1 year) due to diarrheal diseases in children in the municipalities of the state of Goiás However, the results did not show a link between sugarcane mills and these indicators. Therefore, this study corroborates the importance of conducting investigations to monitor and prevent the consequences of environmental changes on the health of populations.
Ectoparasites of non-volant small mammals in a fragmented Cerrado landscape in central Brazil
(2025) Silva, Thaynara Lorrane Linhares da; Carvalho, Raimundo Wilson de; Lopes, Wellington Hannibal; Moreira, Jânio Cordeiro
The diversity of ectoparasites and their relationships with hosts in the fragmented landscape of central Brazil is still poorly understood. This study investigated the ectoparasite communities of mesostigmata mites, ticks, and fleas associated with non-volant small mammals in southern Goiás, Brazil. From January 2020 to May 2022, 10 quarterly field campaigns were conducted, with each lasting from 5 to 7 nights. The captured small mammals were screened for ectoparasites. Order Mesostigmata (n = 8 species) was the predominate group of parasites found on the small mammals, while Siphonaptera (n = 2 species) was found only on Gracilinanus agilis. Gigantolaelaps wolffsohni (n = 80 individuals) was the most frequently found parasitic species, occurring on 1 marsupial (Didelphis albiventris) and 3 rodent species (Calomys tener, Hylaeamys megacephalus, and Oecomys cleberi). This study addresses a knowledge gap by documenting the ectoparasite fauna associated with non-volant small mammals in a fragmented portion of the Cerrado in central Brazil. Knowing the identity of these ectoparasites is essential to understanding species distribution and richness patterns, especially in an anthropogenically altered ecosystems.
Novos registros de cachorro-vinagre em paisagens fragmentadas do sudoeste de Goiás, Brasil central
(2025) Oliveira, Seixas Rezende; Oliveira, Roniel Freitas; Cintra, Maria Cristina Rodrigues; Guilherme, Frederico Augusto Guimarães; Lopes, Wellington Hannibal
First record of albinism in a Crab-eating Fox and review of anomalous coloration in Neotropical carnivores
(2025) Fontoura, Carolina Pereira; Dias, Ana Claudia Bernardes; Oliveira, Ana Kezia Mendes de; Ralla, João Paulo Barbosa; Lopes, Wellington Hannibal
Hypopigmentation can lead to albinism or leucism in animal pelage. This study presents the first documented case of albinism in the Crab-eating Fox (Cerdocyon thous) and explores anomalous coloration in Neotropical carnivores. An albino individual was observed in Nova Maringá, Mato Grosso, Brazil. A literature review identified 12 studies documenting 30 records of anomalous coloration across seven carnivore species, with the Tayra (Eira barbara) showing the highest occurrence (18 cases). Though rare, conditions like albinism and leucism can impact survival by reducing camouflage, communication, and reproduction, underscoring the need for further research into their causes and ecological implications.
Use of Giant Armadillo (Priodontes maximus) burrows by vertebrate species in central Brazil
(2025) Flores, Luana Silva; Lopes, Wellington Hannibal
The Giant Armadillo is considered an ecosystem engineer due to its digging activities, which promote soil aeration and create new habitats. Additionally, its burrows offer thermal refuge, shelter from predators, food sources, and resting sites for other vertebrates. In this study, we investigated which vertebrate species use Priodontes maximus burrows in the Serra da Fortaleza Wildlife Refuge and its surroundings, in southern Goiás, central Brazil. From July 2023 to February 2024, we monitored 20 Giant Armadillo burrows with camera traps, each for approximately 30 days. With a total effort of 596 trap days, we obtained 654 records belonging to 32 vertebrate species (19 mammals, 10 birds, 2 reptiles, and 1 amphibian). Momotus momota, Dasypus novemcinctus, and P. maximus regularly entered the burrows, with M. momota often being observed carrying food and leaves, digging lateral tunnels, and exhibiting behaviors indicative of possible nesting. Rhinella diptycha, Cyanocorax cyanopogon, Cabassous squamicaudis, Dasyprocta azarae, Didelphis albiventris, Dicotyles tajacu, and Tamandua tetradactyla also used the burrows. A usage‐dependent pattern was observed, with D. novemcinctus and P. maximus entering burrows in more than 50% of the observations. We highlight the ecological importance of P. maximus, demonstrating that many species benefit from its excavations.
Global Roadkill Data: a dataset on terrestrial vertebrate mortality caused by collision with vehicles
(2025) Grilo, Clara Bentes; Matos, Tomé Neves de; Bates, Jennifer; Roux, Aliza le; Medrano Vizcaino, Pablo Mauricio; Quaranta, Mattia; Soanes, Inês Silva Kylie; Yun, Wang; Abate, Sergio Damián; Lopes, Wellington Hannibal
Roadkill is widely recognized as one of the primary negative effects of roads on many wildlife species and also has socioeconomic impacts when they result in accidents. A comprehensive dataset of roadkill locations is essential to evaluate the factors contributing to roadkill risk and to enhance our comprehension of its impact on wildlife populations and socioeconomic dimensions. We undertook a compilation of roadkill records, encompassing both published and unpublished data gathered from road surveys or opportunistic sources. GLOBAL ROADKILL DATA includes 208,570 roadkill records of terrestrial vertebrates from 54 countries across six continents, encompassing data collected between 1971 and 2024. This dataset serves to minimise the collection of redundant data and acts as a valuable resource for local and macro scale analysis regarding rates of roadkill, road- and landscape-related features associated with risk of roadkill, vulnerability of species to road traffic, and populations at risk of local extinction. The objective of this dataset is to promote scientific progress in infrastructure ecology and terrestrial vertebrate conservation while limiting the socio-economic costs.

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