Monitoring the circulation of rotavirus among children after the introduction of the Rotarix tm vaccine in Goiânia, Brazil
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Data
2011-06
Autores
Borges, Ana Maria Tavares
Souza, Menira Borges de Lima Dias e
Fiaccadori, Fabíola Souza
Cardoso, Divina das Dores de Paula
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Resumo
The epidemiological features of rotavirus A (RVA) infection differ between children from developing and de-
veloped countries which could result in differences in vaccine efficacy around the world. To evaluate the impact
of RotarixTM on RVA prevalence, we monitored RVA genotypes circulating in Goiânia by monitoring virus in faecal
samples from children that had or had not been previously vaccinated. From February-November of 2008, 220
faecal samples were collected from children in seven day-care centres. RVA detection was performed by two meth-
odologies and the results were confirmed by polyacrylamide gel electrophoresis. From the 220 samples, eight were
RVA-positive (3.6%) and five were from children that had received either one or two doses of the vaccine. All positive
samples were collected from children with diarrhoea during August and September. Genotyping of the RVA charac-
terised five of the viral samples as genotype G2P[4] and one as G8P[4], suggesting that G2P[4] was the predominant
circulating genotype in Goiânia during the study. The fact that vaccinated children were also infected by RVA sug-
gests that the vaccine does not fully protect against infection by the G2[P4] RVA genotype.
Descrição
Palavras-chave
Rotavirus, Epidemiology, Rotavirus infections, Rotavirus vaccine
Citação
BORGES, Ana Maria Tavares; SOUZA, Menira Dias e; FIACCADORI, Fabíola Souza ; CARDOSO, Divina das Dôres de Paula. Monitoring the circulation of rotavirus among children after the introduction of the Rotarix tm vaccine in Goiânia, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 4, p. 499-501, jun. 2011.