Polimorfismo nulo dos genes GSTM1 e GSTT1 na suscetibilidade do câncer renal: evidências baseadas em meta-análise
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Data
2015
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Resumo
Introduction: Renal cancer is a complex
and multifactorial oncourologic disease.
Objective: To conduct a meta-analysis
in order to investigate the association
of GSTM1 and GSTT1 genes null
polymorphisms in renal cancer. Method:
Case-control studies in humans,
published from 1999 to 2013, that
investigated the association of GSTM1
and GSTT1 genes null polymorphisms
in renal cancer were grouped in order to
make of this meta-analysis. Results: Ten
articles were selected on the subject
proposed. No associations were found
between polymorphisms of GSTM1-
null (OR = 1.015, 95% CI = 0.897 to
1.147) and GSTT1-null (OR = 1.081,
95% CI = 0.791 to 1.479) and renal
cancer. Conclusions: Based on the results
obtained, we conclude that the GSTM1
and GSTT1 null polymorphisms are not
associated with the risk of developing
renal cancer, since they have limited role,
if there is any on effective contribution in
the development of renal tumors.
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Palavras-chave
Meta-análise, Neoplasias renais, Polimorfismo genético, Kidney neoplasms, Metaanalysis, Polymorphism genetic
Citação
SILVA, Cláudio Nunes da; SILVA, Douglas Nunes da; MORAES, Katarinne Lima; CORDEIRO, Jacqueline Andréia Bernardes Leão; BRASIL, Virginia Visconde; SADDI, Vera Aparecida; SILVA, Antonio Márcio Teodoro Cordeiro. Polimorfismo nulo dos genes GSTM1 e GSTT1 na suscetibilidade do câncer renal: evidências baseadas em meta-análise. Jornal Brasileiro de Nefrologia, São Paulo, v. 37, n. 2, p. 248-254, 2015.