Cassia occidentalis: effect on healing skin wounds induced by Bothrops moojeni in mice
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Data
2013
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Resumo
Objective: To evaluate the healing activity of an extract from the leaves of Cassia occidentalis on skin wounds induced
by the venom of Bothrops moojeni in mice.
Methods: A total of 24 Swiss albino mice were divided into 4 groups: Group 1 animals were treated for 7 days with
lanette cream; Group 2 animals were treated for 7 days with 10% leaf extract of Cassia occidentalis in lanette cream;
Group 3 animals were treated for 14 days with lanette cream; and Group 4 animals were treated for 14 days with 10% leaf
extract of Cassia occidentalis in lanette cream. To induce wounds, the animals were anesthetised intramuscularly after
the dorsum cervical region was shaved and inoculated intradermally with 4 μg Bothrops moojeni venom. The gross and
histological evaluations were assessed 7 and 14 days after inoculation of the poison.
Results: Extract from the leaves of Cassia occidentalis decreased inflammation and epidermal hyperplasia and increased
the vascular proliferation and reepithelialisation of wounds induced by Bothrops moojeni venom.
Conclusions: These data suggest that the leaves of Cassia occidentalis stimulated the healing of wounds induced by the
dermal venom of Bothrops moojeni in mice, and they can be considered an alternative product to treat wounds caused by
this snakebites.
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Medicinal plants, Angiogenesis, Bothrops
Citação
DELMUT, Maraísa B.et al. Cassia occidentalis: effect on healing skin wounds induced by Bothrops moojeni in mice. Journal of Pharmaceutical Technology and Drug Research, Telangana, v. 2, p. 10, 2013.