FF - Artigos publicados em periódicos

URI Permanente para esta coleçãohttp://200.137.215.59//handle/ri/1420

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Associação entre o ambiente de trabalho de enfermeiros e uso de psicotrópicos: um estudo transversal
(2025) Gadelha, Nayara Siqueira Antunes; Lima , Dione Marçal; Martins, Karine Anusca
Objective:To analyze the relationship between the work environment and the use of psychotropic drugs by nurses. Methods:A cross-sectional analyticalstudy was conducted with 87 nurses from the Municipal Health Department of a city in the metropolitan region of Goiânia, Goiás. The data, collected remotely, covered sociodemographic and professional characteristics, dichotomization of the work environment as favorable or unfavorable to professional practice, mental health conditions, and use of psychotropic drugs. The data were analyzed using tests, descriptive analysis, reliability, and consistency. The analyses were considered statistically significant.Results:Among the participants, 32.2% used psychotropic drugs, 56.3% considered themselves anxious, 50% reported a diagnosis of anxiety, 70.5% considered work an important factor for this use, and 51.7% assessed the work environment as unfavorable to professional practice. Conclusion:The results suggest that nurses are potentially susceptible to the use of psychotropic drugs due to physical and mental exhaustion. The inappropriate and abusive use of these drugs can cause harm to nurses, patients, and health services. The nurses in the sample indicated that their work environment was unfavorable to professional practice and stated that work contributes to mental illness in the category, highlighting it as a relevant factor in the use of psychotropic drugs.This study offers important insights for reflection on the work environment as a risk factor for mental illness and reinforces the need to develop strategies for promoting, preventing, and protecting nurses' mental health.
Análise dos polimorfismos RS10750097 e RS3741298 dos genes da APOA5 em relação as dislipidemias
(2025) Saad, Fernanda Gabriel Aires; Campos, Luiza Moreno Cunha; Gomes, Clayson Moura; Castro, Frank Sousa; Costa, Sérgio Henrique Nascente
Análise da prevalência de dislipidemia em adolescentes atendidos em um laboratório escola
(2025) Almeida, Elisandra Cristina; Silva, Amanda Fonseca Andrade; Castro, Gabriela Gonçalves de; Santos, Thalyta Renata Araújo; Gomes, Clayson Moura; Costa, Sérgio Henrique Nascente
The objective of the study was to analyze the prevalence of dyslipidemias in adolescents attended at the school laboratory of a federal university. This is a retrospective study that used secondary data from tests comprising the lipid profile in patients aged 10 to 19 years from January to December 2023. A total of 612 adolescents were analyzed, with a prevalence of 54.7% dyslipidemic individuals, where about 32.3% had hypertriglyceridemia, 26.6% hypercholesterolemia, 25% had HDL levels below the desired, and 15.8% had increased LDL levels. The analysis of the results also showed higher lipid alterations in females (30.4%) than in males (24.3%). The high percentage of dyslipidemias in childhood and adolescence points to the need for effective public policies and strategies for prevention, early detection, and adequate treatment so that adverse effects related to cardiovascular diseases are minimized in the adult life of the population.
Laboratory analysis of patients infected with the dengue virus
(2025) Lima, Isadora Soares de; Alves, Ana Beatriz Belo; Sanches, Arthur Costa; Feitosa, Fernanda de Oliveira; Silva, Antonio Márcio Teodoro Cordeiro; Costa, Sérgio Henrique Nascente; Gomes, Clayson Moura
Objective: To analyze the laboratory data of patients infected with the dengue virus (DENV) in order to identify characteristic patterns associated with the infection. Methods: A cross-sectional retrospective study was conducted, evaluating secondary laboratory data from 2,117 patients treated at the Laboratory of the Military Police of the State of Goiás (LCHPM) between 2020 and 2022. Data from 389 patients who tested positive for DENV infection through NS1, IgM, and IgG assays were included. The following laboratory parameters were assessed: total leukocyte count, neutrophils, lymphocytes, platelet count, and the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and leukocyte-to-lymphocyte ratio (LLR). The study was approved by the Research Ethics Committee. Results: A total of 389 patients were diagnosed with dengue, showing significant alterations in platelet count (p<0.0001), leukocytes (p<0.0001), lymphocytes (p<0.0001), neutrophils (p<0.0001), and monocytes (p=0.0044), when compared with patients negative for infection. A marked increase in cases was observed in 2022, with a 330% rise between the fourth quarter of 2021 and the third quarter of 2022. Conclusion: The laboratory profile of the analyzed patients confirmed thrombocytopenia, leukocytosis, lymphopenia, monocytosis, elevated neutrophils, and hepatic alterations in infected patients, reinforcing the importance of laboratory and epidemiological analysis in the clinical management of dengue.
Aptidão física do policial militar do estado de Goiás
(2025) Moreira, Linda Denise Fernandes; Pires, Alexandre Tavares; Silva, Jéssica Oliveira da; Costa, Diony Dornélio da; Gomes, Clayson Moura; Costa, Sérgio Henrique Nascente; Castro, Milena Neves de
Perfil laboratorial da função renal de pacientes em um laboratório escola
(2026) Assis, Karolina Lares Fernandes; Machado, Isabella Barbosa; Cruz, Lara Mendonça da; Santos, Thalyta Renata Araújo; Gomes, Clayson Moura; Costa, Sérgio Henrique Nascente
Kidney failure is a serious condition that occurs when the kidneys cannot filter the blood properly. Characterizing specific populations, comparing and optimizing diagnostic techniques are important for advancing the understanding of IR and improving clinical conditions. This study investigated the prevalence of changes in renal function, using the estimate of e-GFR and the albumin-creatinine ratio. A cross-sectional study was carried out on 584 patients who underwent creatinine and albuminuria tests, with 61.5% women and 38.5% men. The majority of patients (83.4%) had preserved or slightly reduced renal function (G1/G2), while 16.6% had moderate to severe impairment (G3-G5). Albuminuria was absent or mild in 58.08% (A1), moderate in 36.81% (A2) and severe in 10.1% (A3). The analysis revealed variation in kidney function, highlighting the importance of risk stratification and early management of chronic kidney disease to guide appropriate clinical decisions.
Effect of the SARS-CoV-2 viral load on hematological and biochemical parameters
(2025) Magalhães, Gustavo Caires Neves; Gomes, Clayson Moura; Assunção, Leandro do Prado; Costa, Sérgio Henrique Nascente; Santos, Fernando Antônio Vinhal dos; Alcântara, Keila Correia de
proportional to the amount of target sequences present in the sample. In various viral diseases, the induction of inflammatory cytokines is strongly correlated with the viral load. However, the viral kinetics of SARS-CoV-2 remain poorly characterized, and its association with disease progression remains controversial. This study aimed to understand the correlation between the SARS-CoV-2 viral load and the biochemical and hematological markers in COVID-19-positive patients. Methods: data from patients with detectable viral load for SARS-CoV-2 treated between March 2020 and May 2021 were collected between Jan/2023 and Jan/2024. Data were analyzed using Qui-square test, Student’s t-test, and analysis of variance. Results: the mean Ct values for the N and ORF1AB genes were 26.73 (±3.95) and 25.93 (±4.75), respectively. A Ct value below the mean for the N and ORF1AB genes, suggesting a higher viral load, was observed in 17.8% (n=152) and 18.4% (n=157) of the patients. The monocyte-to-lymphocyte ratio (MLR) was below the reference value for COVID-19-negative patients (P<0.0001). The C-reactive protein and ferritin levels were higher in patients with COVID-19 (P<0.05). Leucopenia (P<0.001), lymphocytopenia (P<0.001), neutropenia (P<0.001), and thrombocytopenia (P=0.003) were observed more frequently in patients with COVID-19. Conclusion: the MLR below the reference value was more frequent observed in patients with a higher Ct value (lower viral load).
Relação da obesidade com a vitamina D, hormônio tireoestimulante e antígeno prostático específico
(2026) Paula, Isadora Garcia de; Rocha, Taís Garcia; Neves, Roberpaulo Anacleto; Gomes, Clayson Moura
Obesity stems from several factors. It is known that obesity demonstrates alterations in the thyrotropic axis as a response to maintaining body weight, predisposition to vitamin D deficiency and glucose abnormalities, and is one of the controversies surrounding prostate cancer screening. Therefore, it becomes coherent to understand and characterize the peculiar hormonal profile of obese patients and to assist in understanding and consequently planning an optimized treatment. The objective was to consider and explain the physiological changes in vitamin D, Prostate-Specific Antigen (PSA), and Thyroid-stimulating hormone (TSH) values in obese individuals. This is a cross-sectional and retrospective, population-based study that analyzed data from hospital records of military police officers and their dependents treated at the Military Police Hospital in Goiânia. It was found that, regardless of sex, those patients with a higher Body Mass Index (BMI) have altered TSH values. The results demonstrated that serum PSA concentration is directly associated with age, medication use, and BMI of individuals. In the present study, no significant association (p > 0.05) was found between BMI and serum vitamin D levels. However, existing associations were observed between hormonal and neurochemical factors and obesity. Given the endemic growth of this disease, knowledge about the hormonal relationship with excess weight is crucial so that the associations demonstrated in this study can lead to a better understanding of the disease.
Quinazolinones as bioisosteres of Naphthoquinones: a path to potent HsDHODH inhibitors with optimized properties
(2025) Godoi, Bruna Fleck; Bueno, Jéssica Damasceno; Silva, Wemenes José Lima; Purificação, Aline Dias da; Leite, Pedro Ivo Palacio; Santos, Thiago dos; Freitas, Murillo; Silva, Daniel Gedder; Silva, Tais C.; Moraes, Josué de; Andrade, Carolina Horta
Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme in pyrimidine biosynthesis and a target for antiviral therapies against RNA viruses like SARS-CoV-2. Building on prior quinone-based inhibitors, we explored quinazolinones as bioisosteric replacements to reduce cytotoxicity and off-target effects. Through structure-based design, we synthesized quinazolinone derivatives aimed at maintaining critical binding interactions. First-generation compounds showed moderate HsDHODH inhibition (up to 60% at 250 μM), with compound 10c having an IC50 of 25 μM. Using computational modeling, we optimized second-generation derivatives, with 10e showing the highest potency (IC50 = 0.59 ± 0.03 μM) and significant antiviral activity against SARS-CoV-2 (EC50 = 0.15 ± 0.03 μM). These compounds demonstrated improved selectivity compared to naphthoquinone analogs, though challenges with aqueous solubility remain. These results highlight quinazolinones as promising scaffolds for further development of anti-SARS-CoV-2 therapies targeting HsDHODH.
Perfil eletroanalítico de nutracêuticos antioxidantes: implicações para a saúde pública
(2025) Caetano, Marcos Pereira; Gil, Eric de Souza; Nielson, Sylvia Escher de Oliveira; Batista, Érica Aparecida; Macêdo, Isaac Yves Lopes de; Pereira, Marx Osório Araújo; Gornattes, Huagner Rodrigues; Gil, Henric Pietro Vicente
Objective: This study aimed to evaluate different samples of nutraceuticals most recommended by pharmacists in pharmacies and drugstores in Goiânia, Goiás, Brazil. Subsequently, we determined quality aspects of the major products using electroanalytical techniques. Methods: Twelve commercial samples of nutraceutical capsules (3 different brands of each type) were evaluated using voltammetric techniques. Results: The results revealed distinct voltammetric profiles for the samples of Mulberry (Morus nigra), Turmeric (Curcuma longa), Green Tea (Camellia sinensis), and Guarana (Paullinia cupana), with oxidation peaks around Epa1 0.2 V. A significant difference in concentration was identified among the samples (I, II, and III). It is noteworthy that all samples are marketed with the claim of being "identical," which contrasts with the findings.
Evaluation of caffeine content in carbonated and energy drinks using a sensor-modified polyaniline–silver nanoparticles
(2025) Van der Horst, Charlton; Adonis, Shaheeda; Gil, Eric de Souza; Somerset, Vernon
The detection of caffeine (CAF) is essential due to its widespread use and potential health impacts, including effects on sleep and anxiety. In this study, polyaniline (PANI) and PANI doped with silver nanoparticles (AgNPs) were synthesized to effectively detect CAF in beverage samples. The chemically synthesized polymers were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), and electrochemical impedance spectroscopy (EIS) to investigate their morphological and electrochemical properties. Differential pulse voltammetry (DPV) and cyclic voltammetry (CV) were employed to determine CAF concentrations in caffeinated beverages. SEM results revealed that PANI and PANI–Ag films are spherical, with an average diameter of ~100 nm, while TEM analysis showed AgNPs within the PANI–Ag matrix had an average particle size of 5–10 nm. Optimized experimental conditions yielded a linear response for CAF concentrations ranging from 10 to 90 μM, with an R2 value of 0.9935. The detection limit for the PANI–Ag electrochemical sensor was determined to be 0.38 µM (n = 3). This sensor is important for monitoring CAF levels in beverages, contributing to public health awareness and safety, with electrochemical analysis aligning well with labeled values.
Fragment libraries from large and novel synthetic compounds and natural products: a comparative chemoinformatic analysis
(2025) Ramírez-Cid, Verónica; Chávez-Hernández, Ana Luisa; Sánchez López, Osvaldo; Novais, Raul Marques; Price, Temitayo Omowumi Alegbejo; Alves, Kamilla Moraes; Silva, Wemenes José Lima; Emery, Flavio da Silva; Andrade, Carolina Horta; Medina-Franco, José L.
We report comprehensive fragment libraries obtained from large natural product databases and compare their chemical space coverage and diversity with those of synthetic fragment libraries. Specifically, we obtained 2,583,127 fragments derived from the recently updated collection of open natural product (COCONUT) data set with more than 695,133 unique (nonduplicate) natural products and 74,193 fragments derived from the Latin America Natural Product Database (LANaPDB) with 13,578 unique natural products from Latin America. The content, chemical space coverage, and chemical diversity of the natural product libraries were compared to the recently developed CRAFT library, which contains 1214 fragments based on distinct heterocyclic scaffolds and natural product-derived chemicals. The fragment libraries herein obtained and curated are freely available at https://github.com/DIFACQUIM/Fragment-libraries-from-large-synthetic-compounds-and-natural-products-collections.git.
Crystallographic structure of human dihydroorotate dehydrogenase in complex with the natural product inhibitor lapachol
(2025) Purificação, Aline Dias da; Benz, Laila Sofie; Silva, Wemenes José Lima; Emery, Flavio da Silva; Andrade, Carolina Horta; Weiss, Manfred S.; Nonato, Maria Cristina
Dihydroorotate dehydrogenase (DHODH) is a key enzyme in the pyrimidine biosynthesis pathway, playing a critical role in cellular processes and offering therapeutic potential for antiviral, antineoplastic, and autoimmune treatments. Human DHODH (HsDHODH) utilizes ubiquinone as a second substrate, positioning its quinone-binding site as a promising target for inhibitor development. Lapachol, a natural naphthoquinone, has gained prominence as a valuable natural product for the discovery of novel therapeutic agents, thanks to its wide range of biological activities. In this study, we present the first crystal structure of HsDHODH in complex with lapachol, providing valuable insights into the interactions between this natural product and the enzyme. The structure reveals key binding interactions that mediate lapachol’s affinity for HsDHODH and validates previously proposed computational models. Complementary molecular dynamics simulations further highlight the stability of the complex and the importance of water-mediated interactions in ligand binding. These findings enhance our understanding of how naphthoquinone derivatives, such as lapachol, interact with class 2 DHODHs, offering a foundation for the design of optimized inhibitors for therapeutic applications. By integration of structural and computational data, this study contributes to the rational design of novel HsDHODH inhibitors, paving the way for future exploration of lapachol and its derivatives in drug discovery.
Potencial alelopático do extrato de folhas de Spondias purpurea L. (Anacardiaceae) sobre a germinação de sementes de Lactuca sativa
(2025) Dias, Andressa Lanuce Silva; Carvalho, Anna Luiza Silva; Soares, Leticya Alves; Santos, Adelair Helena dos; Romano, Camila Aline; Paula, José Realino de
Spondias is known in Brazil mainly for fruit species which have been studied on different biopotentials and applications of their phytoconstituents. This study aimed to investigate the allelopathic potential of the aqueous extract of Spondias purpurea using the experimental model of Lactuca sativa (lettuce). For chemical characterization, prospecting was performed using classical pharmacognosy techniques. For the bioassay, an aqueous extract at 0.1 g/mL was prepared. A total of 20 L. sativa seeds were exposed to a dilution of 1000 to 10 μg/mL. The seeds were observed for five days and the germinated individuals were counted daily. The presence of phenolic compounds such as flavonoids and tannins. The aqueous extract of the leaves of S. purpurea was efficient in preventing the germination of L. sativa seeds, as well as reducing root and hypocotyl growth by approximately 90%. These results suggest that the aqueous extract of S. purpurea has promising allelopathic potential.
Avaliação do perfil cromatográfico, atividade antimicrobiana e antioxidante das partes aéreas de Marsypianthes chamaedrys (Lamiaceae)
(2025) Paula, José Realino de; Barreto, Rayka Muriele de Sousa; Chaul, Luiza Toubas; Romano, Camila Aline; Abrão, Fernando Yano; Miranda, Julianna Caruliny de; Alves, Virgínia Farias; Fiuza, Tatiana de Sousa
Marsypianthes chamaedrys (Vahl.) is an herb popularly used for vaginal discharge, uterine inflammation, and mycosis. This study aimed to obtain the crude ethanol extract and fractions of the aerial parts of M. chamaedrys, collected in Hidrolândia, Goiás; to carry out thin layer chromatography (TLC); and to evaluate the antioxidant and antimicrobial activities. Antioxidant activity was measured using the DPPH (2, 2-difenil-1-picrilhidrazil) method. Antimicrobial activity was measured using the broth microdilution method. TLC analysis indicated the presence of flavonoids, terpenes, and anthraquinones in the ethyl acetate fraction; terpenes and flavonoids in the dichloromethane fraction; and saponins in the aqueous fraction. Very strong to moderate antioxidant activity was found in the ethyl acetate, dichloromethane, and aqueous fractions (EC50 from 7.57 μg mL-1 to 47.51 μg mL-1). The crude extract and dichloromethane fraction showed activity against Bacillus cereus, Escherichia coli, and Staphylococcus typhimurium. The hexane, dichloromethane, and ethyl acetate fractions showed antifungal activity against Cryptococcus gattii, Candida parapsilosis, Cryptococcus neoformans, Candida albicans, Candida glabatra, and Candida krusei (MIC = 16 to 256 μg mL-1). The antimicrobial activity justifies the popular use of this species and encourages new studies to explore its pharmaceutical potential. This work represents the first description of the antimicrobial activity of M. chamaedrys.
Role of phospholipids on drug dissolution in polymer solid dispersions prepared by hot-melt extrusion
(2025) Carvalho, Danilo Monteiro de; Lourenço, Ana Carolina Mendes; Moreira, Guilherme Gomes; Kasbaum, Fritz Eduardo; Lima, Ana Luiza; Cunha Filho, Marcilio; Taveira, Stephânia Fleury; Marreto, Ricardo Neves
The development of solid dispersions (SDs) has gained increased attention in recent decades, leading to successful delivery systems for various marketed products. In general, combinations of polymers and lipids in SD formulations have shown promising results in reducing the disadvantages associated with the isolated use of hydrophilic excipients such as copovidone (COP) and Soluplus (SLP). This study investigated the influence of the phospholipid (soy phosphatidylcholine, PPC, 15 and 30%, w/w) on the dissolution performance of drug-polymer SDs prepared by hot melt extrusion. A low-solubility model drug (ritonavir, RTV) was selected for the study. A complete drug amorphization was observed for all extrudates despite the PPC presence. However, PPC improved the process yield without requiring a plasticizer. Morphology and particle size analyses revealed the effects of PPC addition in the aqueous dispersions prepared from SDs, denoting a higher polymer–lipid interaction in COP dispersions and the formation of micrometric structures in both COP and SLP dispersions. COP-based SDs produced almost instantaneous increases in RTV dissolution of up to 7-fold, while SLP-based SDs achieved progressive increases over 5-fold. Importantly, PPC incorporation in COP-based SDs did not have an apparent effect on RTV dissolution but significantly improved drug dissolution from the SLP-based SDs. In summary, the role of the lipid mainly depends on the drug-polymer interactions and lipid concentration. Adding phospholipids enables the thermal process without needing other adjuvants.
Spray-dried Celtis iguanaea (Jacq.) Planch (Cannabaceae) extract: building evidence for its therapeutic potential in pain and inflammation management
(2025) Ribeiro, Kátia Regina; Silva, Rúbia Bellard e; Rodrigues, João Paulo Costa; Coimbra, Mairon César; Pereira, Laura Jéssica; Alves, Emmilly de Oliveira; Oliveira, Flávio Martins de; Pereira, Marx Osório Araújo; Gil, Eric de Souza; Carollo, Carlos Alexandre
Celtis iguanaea, widely used in Brazilian folk medicine, is known for its analgesic and anti-inflammatory properties. This study evaluated the in vitro antioxidant capacity and the in vivo antinociceptive and anti-inflammatory mechanisms of the standardized spray-dried Celtis iguanaea hydroethanolic leaf extract (SDCi). Phytochemical analysis showed that SDCi contains 21.78 ± 0.82 mg/g polyphenols, 49.69 ± 0.57 mg/g flavonoids, and 518.81 ± 18.02 mg/g phytosterols. UFLC-DAD-MS identified iridoid glycosides, p-coumaric acid glycosides, flavones, and unsaturated fatty acids. Antioxidant assays revealed an IC50 of 301.6 ± 38.8 µg/mL for DPPH scavenging and an electrochemical index of 6.1 μA/V. In vivo, SDCi (100–1000 mg/kg, p.o) did not impair locomotor function (rotarod test) but significantly reduced acetic acid-induced abdominal writhing and both phases of the formalin test at higher doses (300 and 1000 mg/kg). The antinociceptive effects were independent of α-2 adrenergic receptors. SDCi also increased latency in the hot-plate test and reduced paw edema in the carrageenan model, accompanied by decreased IL-1β and increased IL-10 levels. Histological analysis showed a 50% reduction in inflammatory cell infiltration. These findings support SDCi as an effective anti-inflammatory and antinociceptive phytopharmaceutical intermediate, with potential applications in managing pain and inflammation.
Effects of curcumin on functional capacity and pulmonary function in children and adolescents with cystic fibrosis: a feasibility study
(2025) Albuquerque, Izabela Zibetti de; Costa, Lusmaia Damaceno Camargo; Moura, Rayssa Barbary Pedroza; Taveira, Stephânia Fleury; Marreto, Ricardo Neves; Costa, Paulo Sérgio Sucasas da
This study aims to evaluate the efficacy of curcumin complexed with γ-cyclodextrin on pulmonary function and functional capacity in children and adolescents with Cystic Fibrosis (CF). A double-anonymized, randomized, placebo-controlled clinical trial was conducted involving children and adolescents with CF at a referral center. Over a 6-week period, the control group received a placebo while the intervention group received curcumin complex with γ-cyclodextrin (500 mg). Functional capacity was assessed usingthe 6-minute Walk Test (6MWT), and pulmonary function was evaluated through spirometry. The study enrolled eight patients (four adolescents in each group). The predominant mutation among the groups was heterozygous for ΔF508. There was no change in pulmonary function after the treatment period. The variation in 6MWT showed a trend of increase in the curcumin group (13.5%) compared to the control (8.3%), but it did not reach statistical significance. The preliminary results of this study demonstrated a relevant clinical impact on functional capacity measured by the 6MWT in favor of curcumin use in children and adolescents with CF.
Liquid chromatographic separation and FT-ICR MS of crude oils: insights from polar fractions
(2025) Lima, Nerilson Marques; Machado, Hugo Gontijo; Lima, Gesiane da Silva; Silva Junior, Joveilton Batista da; Cardoso, Juliene Aljahara Sousa; Santos, Gabriel Franco dos; Chaves, Andrea Rodrigues; Silva, Rodrigo Cabral da; Ferreira, Alexandre de Andrade; Vaz, Boniek Gontijo
Molecular characterization of petroleum and reservoir fluids is fundamental to the oil exploration and production sector. However, the complexity of the sample has been an analytical challenge, requiring modern analysis techniques such as ultrahigh-resolution mass spectrometry techniques integrated with chromatographic separation systems. The focus of this study was the detailed molecular characterization of the polar fraction of crude oils, supported by chromatographic fractionation to improve class identification and support geochemical interpretation. Chromatographic fractionations were conducted using H-MPLC, followed by characterization using ESI (±) and APPI (+) FT-ICR MS. Polar compounds from ten Brazilian crude oils were separated into six fractions (low polarity-LP, low medium polarity-LMP, high medium polarity-HMP, high polarity-HP, basic-BAS, acidic-ACD). Molecular profiles through ESI (±) and APPI (+) FT-ICR-MS allowed for the characterization of geochemical processes, formation mechanisms, and the discrimination of oils based on their origin classification and thermal evolution.
Interfacial material in water-in-oil emulsions characterized by ESI(−) FT-ICR MS: evaluation of the influence of centrifugation conditions
(2025) Souza, Luciara Costa de; Souza, Lindamara Maria de; Barros, Eliane Valéria de; Carvalho, Emily Azevedo de; Petroni, Marcos Henrique Oliveira; Folli, Gabriely Silveira; Sad, Cristina Maria dos Santos; Franco, Danielle Mitze Muller; Dufrayer, Gabriel Henry Morais; Vaz, Boniek Gontijo
Emulsion represents a major challenge in the petroleum industry due to its stabilization promoted by polar fractions. In this study, interfacial material (IM) residues were isolated from a naturally emulsified crude oil using a centrifugation-based methodology under different times and temperature conditions. The recovered interfacial materials were characterized by negative-ion electrospray Fourier transform ion cyclotron resonance mass spectrometry (ESI(−) FT-ICR MS). Results showed that longer centrifugation times and higher temperatures reduced the abundance of nitrogen species while enriching oxygenated classes, particularly naphthenic acids and mixed heteroatomic species. Highly aromatic compounds migrated into NO2[H] and NO3[H] classes, whereas both linear and aromatic naphthenic acids, O2[H] class, became more prominent. Van Krevelen diagrams confirmed the increase in aromaticity of the IMR compared with the original emulsion. These findings highlight the role of centrifugation parameters in modulating the composition of IM and provide new insights into the molecular species responsible for emulsion stability.

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