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    Avaliação do reuso de água de limpeza em uma indústria de sabão em pó sintético
    (Universidade Federal de Goiás, 2012-11-06) Santos Junior, Laurive Antonio dos; Lacerda, Monike Fabiane Alves Ribeiro; Sales, Paulo de Tarso Ferreira; Schimidt, Fernando; Santiago, Mariângela Fontes
    The present project aimed to study and evaluate the reuse of water in the cleaning process of making detergent powder, ensuring the product quality as well as reducing the environmental impact by not generating industrial effluent; observing the relationship with following parameters: color, turbidity, pH, alkalinity, COD, total phosphorus and anionic active matter (% w / w). 10 samples were collected in the effluent water reservoir tank washing production of detergent powder, as well as collections were performed 10 base powder produced with the washing water tanks production, aiming to compare the amount of active tense anion present in both samples. The results showed that there was an approximately 1% increase in the amount of anionic active matter in the base powder produced, showing an improvement in product quality without increasing the cost of raw materials. The reuse of washing water tanks production has enabled the production of a product of better quality, economy of raw material, making possible the generation of non‐industrial waste, thereby reducing the environmental impact of such effluent.
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    Caracterização dos casos suspeitos de dengue internados na capital do estado de Goiás em 2013: período de grande epidemia
    (2015-09) Nascimento, Laura Branquinho do; Oliveira, Patrícia dos Santos; Magalhães, Daniel de Paiva; França, Divânia Dias da Silva; Magalhães, Alessandro Leonardo Álvares; Silva, Juliana Brasiel; Silva, Flúvia Pereira Amorim da; Lima, Dione Marçal
    Objective: to describe the clinical and epidemiological features and the spatial distribution of suspected dengue cases admitted to hospital in Goiânia, state of Goiás, during the 2013 epidemic. Methods: this was a descriptive study of suspected dengue cases admitted to hospital in Goiânia based on four databases. Results: 616 suspected dengue cases were included in the study; patients’ mean age was 36 years (SD: 14.8), 55.2% were female, 9.3% were laboratory confirmed and 9.7% had comorbidities; the most common comorbidity was hypertension (20%); the most common warning signs were persistent vomiting (23.7%) and thrombocytopenia (22.7%); laboratory results were positive including for late sample collections taken five days after the onset of symptoms. There was great dispersion in the spatial distribution of cases. Conclusion: the majority of suspected dengue cases admitted to hospital were adults who had warning signs and symptoms
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    Avaliação do serviço de saúde prestado aos pacientes diabéticos em Unidade de Saúde em Goiânia
    (2014) Ribeiro, Emmeline Flor; Sousa, Maria Isabel Caetano de; Campos, Andrea de Paula; Nielson, Sylvia Escher de Oliveira; Lima, Dione Marçal; Provin, Mércia Pandolfo
    Diabetes mellitus is a syndrome of multiple etiology and a major public health problem in Brazil. The control of this disease in basic services is crucial because of its growing magnitude, transcendence, and complex vulnerability. This retrospective study aimed to evaluate the treatment and monitoring of diabetic patients according to the Brazilian Diabetes Society guidelines in two basic health units (UBESFs) in the city of Goiânia/GO. Data were collected by review of medical records from January 2007 to December 2009, resulting in 250 records, consolidated in the Epi InfoTM software. There was a higher frequency of diabetes mellitus type 2 (96.65%) compared to type 1. In 78% of the records, arterial hypertension had been detected and of these, 77.4% had a prescription for ACE inhibitors. In 30.4% of the records, aspirin had been prescribed. On average, a small percentage of the medical records met the recommendations of the Brazilian Diabetes Society: almost 50% of the patients had controlled blood pressure in UBESF unit “A” and over 35% in UBESF unit “B”; about 25% had LDL less than 100mg/dL in both units, and approximately 25% had HbA1c below 7% in UBESF unit “B” and 18% in UBESF unit “A”. As to the study of medication use, 41.1% of the records had prescriptions for metformin and a secretagogue, and only 20.4% of the patients with HbA1c >9% had an insulin prescription.
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    Triterpenes from Minquartia guianensis (Olacaceae) and in vitro antimalarial activity
    (2012) Cursino, Lorena Mayara de Carvalho; Nunez, Cecilia Veronica; Paula, Renata Cristina de; Nascimento, Maria Fernanda Alves do; Santos, Pierre Alexandre dos
    Minquartia guianensis, popularly known as acariquara, was phytochemically investigated. The following triterpenes were isolated from the dichloromethane extract of leaves: lupen-3-one (1), taraxer-3-one (2) and oleanolic acid (3). The dichloromethane extract of branches yielded the triterpene 3β-methoxy-lup-20(29)-ene (4). The chemical structures were characterized by NMR data. Plant extracts, substance 3, squalene (5) and taraxerol (6), (5 and 6 previously isolated), were evaluated by in vitro assay against chloroquine resistant Plasmodium falciparum. The dichloromethane extract of leaves and the three triterpenes assayed have shown partial activity. Thus, these results demonstrated that new potential antimalarial natural products can be found even in partially active extracts
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    Insecticidal activity of Vitex cymosa (Lamiaceae) and Eschweilera pedicellata (Lecythidaceae) extracts against Sitophilus zeamais adults (Curculionidae)
    (2012) Oliveira, Taciane Almeida; Teles, Beatriz Ronchi; Fonseca, Claudio Ruy Vasconcelos da; Silva, Sérgio Luiz Rodrigues da; Santos, Pierre Alexandre dos; Nunez, Cecilia Veronica
    This study evaluated insecticidal and repellent effects of Vitex cymosa and Eschweilera pedicellata extracts against Sitophilus zeamais adults. Contact on filter paper discs and contaminated grain ingestion assays were performed. The repellent effect was evaluated with the “preferential area” method. The extracts provided good results by ingestion and as repellents, but not by contact. V. cymosa branches methanol extract was the best, killing nearly 70% of the individuals at its highest concentration, followed by V. cymosa flowers dichloromethane extract and E. pedicellata branches aqueous extract. Among these, only V. cymosa leaves dichloromethane extract did not reduce the number of individuals in F1. Analyzing the repellent effect, when the variable concentration was taken into account, no extract was dose-dependent, and the intensity of response varied with the time interval. Among the extracts tested, V. cymosa branches methanol extract is the most promising one, which negative effect on parental resulted in F1 decrease number and the ingestion way was the most efficient.
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    Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazon
    (2013-12) Coutinho, Julia Penna; Aguiar, Anna Caroline Campos; Santos, Pierre Alexandre dos; Lima, Joaquim Corsino; Rocha, Maria Gabrielle Lima; Zani, Carlos Leomar; Alves, Tânia Maria Almeida; Santana, Antônio Euzébio Goulart; Pereira, Maria de Meneses; Krettli, Antoniana Ursine
    Infusions of Aspidosperma nitidum (Apocynaceae) wood bark are used to treat fever and malaria in the Amazon Region. Several species of this family are known to possess indole alkaloids and other classes of secondary me tabolites, whereas terpenoids, an inositol and the indole alkaloids harmane-3 acid and braznitidumine have been described in A. nitidum. In the present study, extracts from the wood bark, leaves and branches of this species were prepared for assays against malaria parasites and cytotoxicity testing using human hepatoma and normal monkey kidney cells. The wood bark extracts were active against Plasmodium falciparum and showed a low cytotoxicity in vitro, whereas the leaf and branch extracts and the pure alkaloid braznitidumine were inactive. A crude methanol extract was subjected to acid-base fractionation aimed at obtaining alkaloid-rich fractions, which were active at low concentrations against P. falciparum and in mice infected with and sensitive Plasmodium berghei parasites. Our data validate the antimalarial usefulness of A. nitidum wood bark, a remedy that can most likely help to control malaria. However, the molecules responsible for this antimalarial activity have not yet been identified. Considering their high selectivity index, the alkaloid-rich fractions from the plant bark might be useful in the development of new antimalarials
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    Antioxidant activity of a standardized extract of Byrsonima japurensis A. Juss. (Malpighiaceae) stem bark
    (2013-07) Guilhon-Simplicio, Fernanda; Souza, Tatiane Pereira de; Alonso, Alexandre Antônio; Almeida, Patrícia Danielle Oliveira de; Santos, Pierre Alexandre dos; Ohana, Débora Teixeira; Lima, Emerson Silva; Pereira, Maria de Meneses
    An infusion of 5% Byrsonima japurensis stem bark, an Amazonian medicinal plant, presented anti-inflammatory, anti-hyperalgesic, antiplatelet and antiulcer activity in a previous study. In this study, pharmacognostical parameters for this raw material were determined and the technological characterization of the infusion was performed, concurrently with the assessment of their antioxidant potential. The analysis of the raw material and the crude extract was done using pharmacopoeial and non-pharmacopeial methods. The antioxidant potential was evaluated by diphenylpicrylhydrazyl (DPPH•), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•+) and nitric oxide (NO•) radical scavenger assays. The raw material presented a mean size of particles of 318.30 ± 1.65 µm, ash content of 3.39 ± 0.04 g%, 10.32 ± 0.09 g% loss on drying and 12.23 ± 0.17 g% of matter extractable by water. The extract obtained by infusion of 5% of plant drug is rich in polyphenol compounds (50.69 ± 3.64 mg GAE/g) with appreciable flavonoid content (2.38 ± 1.15 mg quercetin/g). This extract showed expressive antioxidant activity, which was significantly better than ascorbic acid and Trolox in both DPPH and ABTS radical scavengers tests (p < 0.05), which is closely related to its previously detected anti-inflammatory activity
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    Educação farmacêutica discutida em eventos científicos
    (2012) Dewulf, Nathalie de Lourdes Souza
    Continuing education and quality training are essential for good performance of professional and development of professional practical improvements. Participation in courses and congresses contributes to this aim. Some scientific organizations, during its events, the concern about education are highlighted, bringing critical and reflective discussions about new directions, such as interprofessional education (IPE). IPE occurs when two or more professions learn with, from and about each other, to improve collaboration and the quality of care. Such changes should be considered in the curriculum reform movement, as well as in continuing education for professionals already in the market. Still, the realization of scientific events is fundamental, that provides not only the dissemination of ideas, but also develops the critical spirit of the participants. Therefore, all will be/would be really encouraged to change the reality of professional practice.
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    Cinema: uma ferramenta pedagógica e humanista para temas em saúde-educação. A experiência do CineSocial
    (2011) Xavier, Joab Jefferson da Silva; Dewulf, Nathalie de Lourdes Souza; Peres, Cristiane Maria; Barros, Gisele Curi de; Pfrimer, Karina; Nakao, Claudia Satiê; Leite, Francine; Silva, Rafael J. A.; Santos, Ricardo L. R.; Monteiro, Rosane A.; Antonio Ruffino Netto, Antonio; Carvalho, Antonio C. D.
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    Pharmacoepidemiological profile and polypharmacy indicators in elderly outpatients
    (2013-09) Baldoni, André de Oliveira; Ayres, Lorena Rocha; Zangiacomi Martinez, Edson; Dewulf, Nathalie de Lourdes Sousa; Santos, Vânia dos; Obreli Neto, Paulo Roque; Pereira, Leonardo Régis Leira
    This cross-sectional study was carried out with 1000 elderly outpatients assisted by a Basic Health District Unit (UBDS) from the Brazilian Public Health System (SUS) in the municipality of Ribeirão Preto. We analyzed the clinical, socioeconomic and pharmacoepidemiological profile of the elderly patients in order to identify factors associated with polypharmacy amongst this population. We used a truncated negative binomial model to examine the association of polypharmacy with the independent variables of the study. The software SAS was used for the statistical analysis and the significance level adopted was 0.05. The most prevalent drugs were those for the cardiovascular system (83.4%). There was a mean use of seven drugs per patient and 47.9% of the interviewees used ≥7 drugs. The variables that showed association with polypharmacy (P value < 0.01) were female gender, age >75 years, self-medication, number of health problems, number of medical appointments, presence of adverse drug events, use of over-the-counter drugs, use of psychotropic drugs, lack of physical exercise and use of sweeteners. The exposition to all these factors justified the high prevalence of polypharmacy amongst the interviewees. These results showed the need to adopt clinical intervention and educational and managerial measures to analyze and promote rationality in the use of drugs amongst the elderly users of SUS
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    Análise de prescrições médicas para tratamento de câncer de mama em um hospital universitário do estado de São Paulo
    (2014) Bózoli, Luís Felipe Beloni; Ribeiro, Camila Milani; Zoccal, Polyana Lara de Mello; Ferreira, Iahel Manon de Lima; Fernandes, Rodrigo Marangoni; Sakamoto, Luiz Maçao; Abramovicius, Alexandra Cruz; Andrade, Jurandyr Moreira de; Dewulf, Nathalie de Lourdes Souza; Ungari, Andrea Queiróz
    This article focuses on the analysis of prescriptions for the treatment of breast cancer in patients followed up in a university hospital in the state of São Paulo. The study analyzed 408 prescriptions between September and December 2012, with 201 in Chemotherapy Center and 207 in Chemotherapy Pharmacy in this teaching hospital. The main results were: (a) from 201 prescriptions analyzed in Chemotherapy Center, only 123 (61.2%) had weight, 89 (44.3%) height and 113 (56.2%) of the body surface patient; (b) 100% of prescriptions in Chemotherapy Center and 48.3% in the Chemotherapy Pharmacy showed abbreviations; (c) the trade name of the drug was present in 54.7% of prescriptions in Chemotherapy Center; (d) high rates of absence of information about the pharmaceutical form of the drug; (e) 05 (1.2%) prescriptions with illegible name of the patient and 04 (1%) prescriptions with illegible name of the drug. Data analysis shows the absence of complete information necessary for the safe use of anticancer drugs, if not evidencing compliance with current legislation. Thus, we highlight the importance of continuous training of physicians about the importance of a clear and complete prescription, as well as greater participation of clinical pharmacists and suggest also the implementation of the electronic prescription. These actions can improve the quality of prescriptions and promote the safe and rational use of medicines.
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    Educação em saúde aos usuários de formulações magistrais da farmácia universitária da Universidade Federal de Goiás: um relato de experiência
    (2014) Cardoso, Thaissa Costa; Ferreira, Tatyana Xavier Almeida Matteucci; Prudente, Luciana Resende; Dewulf, Nathalie de Lourdes Souza
    The Rational Use of Medicines was defined by the World Health Organization as a goal to be achieved due to the alarming data related to complications caused by the misuse of drugs. In our country, factors such as self-medication, poor access to health services, poor adherence to drug treatment, and lack of patient education are obstacles to the effective implementation of the Rational Use of Medicines. The reestablishment of the relationship between the pharmacist and the patient in community pharmacies, involving the dispensing of medicines, leaflets, and other pharmaceutical services, is consolidating as a way of implementing the Rational Use of Medicines. Prescription drugs do not have legislation to regulate and standardize leaflets supporting the guidelines given verbally by health professionals to the users. To meet this need, in this extension project, sixteen leaflets were developed for users of the University pharmacy at the Federal University of Goiás. These were produced according to Brazilian regulations, using accessible language and objectives, in order to provide an effective and low cost way of promoting the Rational Use of Medicines
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    Dificuldades de acesso aos serviços farmacêuticos pelos idosos
    (2014) Baldoni, André de Oliveira; Dewulf, Nathalie de Lourdes Sousa; Santos, Vânia dos; Ayres, Lorena Rocha; Pereira, Leonardo Régis Leira
    The aim of this study was to analyze the access to pharmaceutical services by the elderly provided by the Unified Health System in the municipality of Ribeirão Preto – SP, Brazil, as well as their knowledge about the correct form of using the prescribed medication. A cross sectional study was performed with elderly patients aged 60 years and older in the moment that they withdrawal their medications at a public pharmacy in the municipality of Ribeirão Preto – SP. A standardized form was used for data collection performed between November 2008 and May 2009. We interviewed 1000 elderly, of which less than half (46.8%) acquired all the medications contained in the prescription through the Unified Health System. In addition, 31.3% of the interviewees did not acquired the prescribed medication by a lack of at least one medication in the standardized list of the municipality. More than 87.4% of the elderly claimed they did not receive guidance from the pharmacist in the moment of drug dispensing, 37.1% reported a lack of knowledge of the correct dosage form of the medications used and 62,2% of the elderly interviewed stopped using the prescribed medication once during the treatment period. It is noteworthy that 15.8% of the respondents have also private health insurance. Access barriers to prescribed medication and the lack of knowledge about the dosage highlight deficiencies with respect to pharmaceutical services offered by the Unified Health System of Ribeirão Preto – SP
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    Gerenciamento de medicamentos em desuso devolvidos por pacientes ambulatoriais de um hospital universitário
    (2014) Primo, Lilian Pereira; Rodrigues, João Paulo Vilela; Ayres, Lorena Rocha; Ferreira, Iahel Manon de Lima; Dewulf, Nathalie de Lourdes Souza; Abramovicius, Alexandra Cruz
    The purpose of this study was to analyze the profile of leftover medicines returned to the pharmacy of the Specialized Component of Pharmaceutical Services at the General Teaching Hospital of the Faculty of Medicine at Ribeirão Preto, University of São Paulo, and the profile of their final destination. This was a cross sectional descriptive study based on the collection of the following data: identity of the patient or responsible person, motive for the return and information about the medicine returned to the pharmacy (batch number, expiry date, quantity returned and storage conditions). We analyzed the data collected in response to a structured questionnaire and also assessed the visual appearance of the returned medicines, which were either classified as suitable for reuse by other patients or sent for disposal. Costs related to the medicine returned to the institution were calculated and analyzed. Data collection was performed in July 2011. During this month, the pharmacy received 34 returns, totaling 2149 units of medicine. Of these, 82.4% were intact, 6.0% were thermolabile and only 3.0% had expired, while 76.5% of all medicines were reused. The financial value of all returned items was R$ 5,759.90 and the total savings from the reuse of medicines represented R$ 4,743.34. Encouragement to return leftover medicine, provided by implementing an effective medication management system, would offer safety to the patient and environment and financial savings for the health system. For this reason, the healthcare team should be able to give advice on correct storage, to ensure integrity and quality of the active moiety, favoring an optimal therapeutic outcome for those patients who will reuse them.
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    Vitamin serum level variations between cycles of intermittent parenteral nutrition in adult patients with short bowel syndrome
    (2013-01) Ferreira, Iahel Manon de Lima; Braga, Camila Bitu Moreno; Dewulf, Nathalie de Lourdes Souza; Marchini, Julio Sérgio; Cunha, Selma Freire de Carvalho da
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    Análise tecidual e celular das brânquias de Oreochromis niloticus L. tratadas com extrato etanólico bruto e frações das folhas da pitanga (Eugenia uniflora L.) - Myrtaceae
    (2011) Fiuza, Tatiana de Sousa; Silva, P. C.; Paula, José Realino de; Tresvenzol, Leonice Manrique Faustino; Souto, M. E. D; Saboia-Morais, Simone Maria Teixeira de
    Eugenia uniflora L. (Myrtaceae) is a plant found in the Cerrado biome and traditionally used in the treatment of diarrheas, inflammations, hyperglycemia and hypertension. Previous studies have revealed in vitro antimicrobial activity of E. uniflora. Considering its popular use, this study aimed to assess possible systemic cellular and tissue activities of the crude extract and the fractions from the leaves of this plant on Oreochromis niloticus L. (Nile tilapia) gill. Thus, ethanol extract and fractions from the leaves of this plant were orally administered to the fish in their rations. After 24 hours, the fish were sacrificed and the second gill arch of each fish was dissected, fixed in neutral formalin, dehydrated, embedded in paraffin and sectioned. Masson’s trichome and hematoxylin and eosin (HE) were used in the histological analyses. Qualitative analyses using a light microscope led to the conclusion that the crude ethanol extract and the fractions from E. uniflora leaves presented systemic effect on Nile tilapias, affecting the gills. Toxic actions such as respiratory epithelium detachment and lifting, and hyperplasia of interlamellar epithelial cells were more pronounced in the tilapias that ingested higher concentrations. This study helped to identify the vasodilator effect of this plant and contributed to the definition of the Nile tilapia as a model system for testing plant active principles. These tests are expected to make feasible not only the use of plants as fish medication but also the maintenance of the health of animals in intensive and extensive cultures through the possible use of alternatives to synthetic medication
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    Composição química e atividade antimicrobiana dos óleos essenciais das folhas e flores de Callistemon viminalis (sol. ex Gaertn.) G. Don ex. Loudon (Myrtaceae)
    (2013) Pires, Cyndi Heleinne; Paula, Joelma Abadia Marciano de; Tresvenzol, Leonice Manrique Faustino; Ferri, Pedro Henrique; Paula, José Realino de; Fiuza, Tatiana de Sousa; Bara, Maria Teresa Freitas
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    Análise da atividade antimicrobiana das folhas de Davilla elliptica St.-Hil. (Dilleniaceae)
    (2009) Soares, M. L.; Bustamante, K. G. L.; Echalar, Adda Daniela Lima Figueiredo; Pimenta, Fabiana Cristina; Fiuza, Tatiane de Sousa; Bara, Maria Teresa Freitas; Tresvenzol, Leonice Manrique Faustino; Paula, José Realino de
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    The effect of crude ethanol extract and fractions of Hyptidendron canum (Pohl ex Benth.) Harley on the hepatopancreas of Oreochromis niloticus L
    (2009-05) Fiuza, Tatiana de Sousa; Silva, Paulo C.; Paula, José Realino de; Tresvenzol, Leonice Manrique Faustino; Saboia-Morais, Simone Maria Teixeira de
    Hyptidendron canum (Pohl ex Benth.) Harley is a native tree of the Brazilian Savannah. The fish Oreochromis niloticus L. was used as an experimental model to determine the bioactivity of the crude ethanol extract as well as ethyl acetate, hexanic and chloroform fractions obtained from its leaves. The plant ethanol extract and fractions were administered to the fish orally with their feed. Twenty four hours later, the fish were sacrificed and their livers dissected, fixed in neutral formalin, embedded in paraffin and sectioned. Histological analyses were performed using Masson’s trichrome and Haematoxylin-Eosin. Histochemical studies were performed using Feulgen, PAS (Periodic Acid Schiff) and PAS + salivary amylase and Sudan IV stain. The qualitative analysis of the material showed that both the crude ethanol extract and the fractions from H. canum induced vasoactive activity, causing vasodilation and vascular congestion, and the hexanic fraction also caused an apparent proliferation of capillaries. Hepatopancreas toxicity was evident through inflammatory processes. Pancreatic (chloroform fraction) and hepatic alterations, hemorrhagic spots and necroses were observed in fish treated with ethanol extract and fractions. This study is the first description of the biologic action of the crude ethanol extract and the hexane, ethyl acetate and chloroform fractions in fish.
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    Antimicrobial activity of the crude ethanol extract from Hyptidendron canum leaves
    (2009) Fiuza, Tatiana de Sousa; Sabóia-Morais, Simone Maria Teixeira de; Paula, José Realino de; Tresvenzol, Leonice Manrique Faustino; Pimenta, Fabiana Cristina
    This study proposed to evaluate the antimicrobial activity of the crude ethanol extract of Hyptidendron canum (Pohl ex Benth.) Harley (Lamiaceae) leaves. The crude ethanol extract was obtained from the dried, pulverized leaves. The H. canum leaf powder was submitted to phytochemical screening. The antimicrobial activity was evaluated against Gram-positive and -negative bacteria and Candida albicans using the well diffusion test and the agar dilution method for determining the minimum inhibitory concentration (MIC). Phytochemical screening showed the presence of flavonoid and saponinic heterosides. The extract demon strated antimicrobial activity against all microorganisms tested. The MIC for non-sporulated Gram-positive bacteria varied from 4.37 to 17.5mg/mL. The sporulated Gram-positive bacteria tested had their growth inhibited by H. canum (MIC from 4.37 to 35mg/mL). The MIC of H. canum for most of the Gram-negative bacteria was 70mg/mL, except for Pseudomonas aeruginosa (MIC = 17.5mg/mL), at which concentration C. albicans was also inhibited. This is the first report of phytochemical screening and antimicrobial activity of H. canum.