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Análise das notificações de eventos atribuíveis à vacinação ou imunização das vacinas do covid-19 em Goiânia, Goiás, Brasil
(2025) Rodrigues, Beatriz Guimarães; Oliveira Junior, Ronaldo Rodrigues de; Lopes, Angela Ferreira; Dewulf, Nathalie de Lourdes Souza; Lopes, Flávio Marques
Introduction: The pandemic caused by the SARS-Cov-2 virus, which causes the disease COVID-19, caused a high socioeconomic impact in just a few months, a sharp increase in the incidence of deaths, complications and irreversible damage to the clinical picture of the affected population, giving rise to the need for emergency use of immunobiologicals. In Brazil, the use of the AstraZeneca and CoronaVac vaccines was initially approved. Every vaccine is likely to cause adverse reactions, therefore it is essential to report possible post-vaccination adverse events. Objective: to analyze the ESAVI reported for the AstraZeneca and CoronaVac vaccines in the year of implementation of the vaccination schedule in the National Immunization Program (PNI). Methodology: A descriptive cross-sectional study was carried out, using information present in the secondary database originating from the E-SUS Notifica platform. The data was categorized by key variables, and subsequently statistically analyzed, using Excel Office 16. Results: 0.036% of vaccine doses administered in 2021 were reported under suspicion of ESAVI. The majority of notifications were made by women aged between 36 and 49 years. Health professionals also contributed by reporting ESAVI to health authorities. However, pregnant women were the smallest (priority) group who presented and/or reported any possible adverse reactions. Conclusion: It can be concluded that the majority of ESAVI reported were not serious, with a cure outcome without sequelae, showing that vaccination is still the best way to reduce the impacts caused by viruses.
Arcabouço normativo relacionado à indicação e prescrição de medicamentos fitoterápicos por farmacêuticos no Brasil
(2025) Parreira, Ana Paula Gomes; Silva, Luana Inácia Ferreira; Dewulf, Nathalie de Lourdes Souza
Objective:analyze the regulatory aspects associated with pharmaceutical prescription of herbal medicines in Brazil. Methodology:an integrative review, a gray literature search and a document analysis were carried out. The databases used for the integrative review were Medical Literature Analysis and Retrieval System Online, Latin American and Caribbean Literature on Health Sciencesand Scientific Electronic Library Online, covering the period from January/2008 to December/2023. The gray literature search was undertaken on Google Academic. The document analysis was conducted on websites of institutions relevant to the pharmaceutical practice, such as the Brazilian National Association of Magistral Pharmacists, the Brazilian Health Regulatory Agency and the Brazilian Ministry of Health. Results:few studies on the prescription of herbal medicines by pharmacists were identified, mainly concentrated in primary care. Professional insecurity was observed, associated with lack of preparation and gaps in academic training. Some studies highlighted the relevance of the pharmacist in phytotherapy, while others pointed to the absence of specific regulation. A divergence was found between the requirements established for prescription and the lack of requirements for dispensing. Official documents were identified, such as the National Policy on Integrative and Complementary Practices, the National Policy on Medicinal Plants and Phytotherapeutics, and Federal Council of Pharmacy resolutions, which provide regulatory support. Conclusion:regulation has advanced in the integration of herbal medicines into pharmaceutical care, promoting evidence-based action for the pharmaceutical indication and prescription of herbal medicines.
Effect of the SARS-CoV-2 viral load on hematological and biochemical parameters
(2025) Magalhães, Gustavo Caires Neves; Gomes, Clayson Moura; Assunção, Leandro do Prado; Costa, Sérgio Henrique Nascente; Santos, Fernando Antônio Vinhal dos; Alcântara, Keila Correia de
Objective: the viral load is determined by the cycle threshold (Ct), which is inversely proportional to the amount of target sequences present in the sample. In various viral diseases, the induction of inflammatory cytokines is strongly correlated with the viral load. However, the viral kinetics of SARS-CoV-2 remain poorly charac-terized, and its association with disease progression remains controversial. This study aimed to understand the correlation between the SARS-CoV-2 viral load and the biochemical and hematological markers in COVID-19-positive patients.Methods: data from patients with detectable viral load for SARS-CoV-2 tre-ated between March 2020 and May 2021 were collected between Jan/2023 and Jan/2024. Data were analyzed using Qui-square test, Student’s t-test, and analysis of variance.Results: the mean Ct values for the N and ORF1AB genes were 26.73 (±3.95) and 25.93 (±4.75), respectively. A Ct value below the mean for the N and ORF1AB genes, suggesting a higher viral load, was observed in 17.8% (n=152) and 18.4% (n=157) of the patients. The monocyte-to-lymphocyte ratio (MLR) was below the reference value for COVID-19-negative patients (P<0.0001). The C-reactive protein and ferritin levels were higher in patients with COVID-19 (P<0.05). Leucopenia (P<0.001), lym-phocytopenia (P<0.001), neutropenia (P<0.001), and thrombocytopenia (P=0.003) were observed more frequently in patients with COVID-19.Conclusion: the MLR below the reference value was more frequent observed in patients with a higher Ct value (lower viral load).
Cultura organizacional em hospitais públicos: uma análise comparativa entre modelos de gestão direta e organizações sociais
(2025) Ferreira, Beatriz Xavier Almeida Matteucci; Reis, Vanessa de Assis; Torres, Thais dos Santos Ferreira; Silva, Ana Clara Cardoso Oliveira; Provin, Mércia Pandolfo
Introduction: This article addresses organizational culture in two public hospitals with distinct management models. Obective: aiming to comprehend the resultant culture in each entity and to assist managers and healthcare professionals identify strengths and weaknesses, improving care results. Method: Comparative cross-sectional study conducted between public hospitals, one under direct management (DM) and the other managed by a Social Organization (SO) in the Central-West region of Brazil, using non-probabilistic sampling. The Brazilian Organizational Culture Assessment Instrument (IBACO) was applied to analyze organizational values and practices, with responses collected from 363 participants between 2019 and 2020.The cross-sectional study was carried out in two public hospitals, one administered by a social organization (SO), the other directly by the public sector (PS). The data was collected between 2019 and 2021 and 363 workers from the institutions responded to the Brazilian Instrument for Assessment of Organizational Culture. Results: Both the SO management model and the PS model highlighted cooperation in the workplace as the most prominent cultural value (3.3 and 2.6 points, respectively). Subsequently, rigidity in the hierarchical power structure was observed (2.8 and 2.6, respectively). Regarding observable behaviors, the practice of external integration (3.5 and 2.7, respectively) was most noticed. Therefore, cooperative professionalism emerges as a shared value in both organizational contexts. However, there are nuances in the practices and values identified, delineating disparities. Conclusion: In the hospital managed by SO, the adoption of external integration practices is mediated by the presence of a more rigid hierarchical structure. At the PS hospital, the emphasis on external integration is based on client centricity, revealing a propensity for greater organizational adaptability.
Management of medication errors in oncological patients: a cross-sectional study and case reports of pharmaceutical interventions in a university hospital in central-west Brazil
(2026) Pontes, Esther Domenici Mozzer; Martins, Renato Rocha; Fernandes, Paulo Augusto Souza; Lopes, Angela Ferreira
Introduction Antineoplastic chemotherapy (ACT) is widely used, but involves significant risks due to protocol complexity and inherent toxicity. Pharmacists play a key role in validating ACT prescriptions to enhance patient safety. Objective To analyze medication errors during ACT prescribing and describe pharmaceutical interventions performed to manage these errors at a Federal University Hospital in the Central-West region of Brazil. Methodology This cross-sectional study, supplemented with case reports, was conducted between January 2023 and July 2024. A total of 382 prescriptions for 208 oncology outpatients were analyzed; only prescriptions with previously identified medication errors were included in this study. Medication errors were classified as decision-making or writing errors according to the Pharmaceutical Care Network Europe (PCNE) classification and Dean et al. (2000), and categorized by severity using the NCC MERP framework. Data were extracted from an institutional database and validated by an oncology specialist pharmacist. Only deviations with potential pharmacological or clinical impact were classified as decision-making errors, excluding minor operational adjustments. Results Decision-making errors occurred in 91.6% (n = 358/391) of prescriptions, primarily due to inappropriate diluent volumes (91%), while writing errors were observed in 8.4% (n = 36/391), mainly from missing clinical information. Pharmaceutical interventions were accepted in 99% of cases, preventing errors from reaching patients. Most errors were intercepted before administration (NCC MERP Category B), though two cases had potential clinical consequences (Category C) and one required patient monitoring due to communication issues (Category D). Conclusion Specialized oncology pharmacists play a critical role in ensuring the safety of ACT prescribing. The high proportion of decision-making errors observed within this selected sample emphasizes the need for systemic improvements, such as integrated electronic prescribing and continuous pharmacist-led oversight, to reduce preventable errors and enhance patient safety.
Pharmacy practice in a veterinary hospital: development and application of a tool for inspection of medication labeling and packaging
(2025) Soares, Lorena Mendes; Catão, Alaine Maria Lopes; Lopes, Angela Ferreira
Objectives: This study aimed to develop and apply a tool to guide the inspection of technical parameters of medications used in veterinary health services, supporting practices that contribute to animal patient safety in accordance with current regulations. Methods: The Inspection Guide for Technical Aspects of Labeling of Medicines for Veterinary Use (RIATREvet) was designed from Brazilian regulations issued by Anvisa and MAPA, the agencies responsible for human and veterinary drug control, respectively. The tool was implemented at the veterinary hospital of the Federal University of Goiás, central-west region of Brazil, to assess compliance with medications used in animal care. Results: The RIATREvet covered three domains and 16 items. It was applied to 67 medications (58.2% human, 41.8% veterinary). Human drugs achieved near-total regulatory compliance (≥98%). Conversely, veterinary drugs exhibited significantly lower compliance, notably in primary packaging (Domain 1: 71.4%) and secondary packaging (Domains 1 and 2: ≤84%). The most frequent non-conformity was Item 3.3 (“Customer Service Phone Number”), with veterinary drugs showing a significantly higher failure rate (64.3%, p<0.001). High-risk APINCH medications (52.2% of the sample) showed high non-compliance, particularly for primary packaging (65.7%), increasing the risk of medication errors. Conclusion: The RIATREvet tool effectively guides veterinarians and pharmacists in evaluating medication labeling and packaging, thereby contributing to safer medication use in veterinary healthcare services.
Vigilância em saúde no enfrentamento da COVID-19 no Brasil: uma revisão de escopo
(2025) Borges, Larissa Araújo; Silva, Pedro Henrique Brito da; Zara, Ana Laura de Sene Amâncio; Oliveira, Ellen Synthia Fernandes de
The management of the COVID-19 pandemic in Brazil was marked by contradictory statements and controversial decisions by the head of the executive branch and the Ministry of Health, creating uncertainty about the effective implementation of federal actions to control the disease. This study aims to describe the main health surveillance strategies adopted by the federal government to combat COVID-19, with a focus on actions aimed at preventing SARS-CoV-2 infection. This is a scoping review conducted between November 2019 and January 2021, using DECS and MeSH descriptors in four databases, in addition to consulting 85 legislative documents available on the Brazilian government’s legislation portal. The analysis included ten scientific articles and identified federal actions related to non-pharmacological and pharmacological measures, decisions on international borders, procurement of supplies, and essential services. The results point to the presence of sporadic strategies for pandemic containment but reveal insufficient surveillance in the face of the number of cases and deaths recorded. The study highlights the lack of robust federal support, which hindered the coordination and planning.
Microcefalia e recursos terapêuticos não farmacológicos: revisão integrativa
(2025) Rodrigues, Márcia Elisabeth; Amâncio, Ana Laura de Sene; Passos, Zara Saulo Duarte
Microcephaly is characterized in newborns by a head circumference of less than two standard deviations below the mean, considering gestational age, sex, and population. It has multifactorial and complex causes, affecting the nervous system in the fetus or, later, impacting the child's development and adaptation to the environment. To date, there is no specific treatment. The objective of this integrative review was to collect, analyze, and synthesize the available evidence involving non-pharmacological therapeutic resources provided to babies or children under five years old with microcephaly. The guiding question was "What non-pharmacological therapeutic resources are provided to infants or children with microcephaly?". Between August 2023 and January 2024, the databases were consulted: Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, BVS, PubMed, LILACS MEDLINE, Google Scholar, websites of the Ministry of Health, World Health Organization, Pan American Health Organization in Portuguese, Spanish, French, and English, with no initial publication limit. Of the 3980 publications found, 31 were selected, highlighting the therapeutic resources in the preferred age between zero and three years: Early Stimulation, Physiotherapy, Bobath Method, Therapeutic Clothing, Canine Assisted Therapy, Padovan Method, Goals, Activity and Motor Enrichment, Intervention, and Responsive Care, administered by professionals from public agencies and universities. Conclusion: Early stimulation was the most cited resource. Family participation proved necessary. Given that there is no known cure for microcephaly, it is essential to continue research, expand existing therapies, and provide ongoing support to children, families, involving different professionals and institutions.
Impacto financeiro da aquisição centralizada de rituximabe pelo Ministério da Saúde para tratamento de linfomas, 2015-2022: estudo exploratório
(2025) Martins, Renato Rocha; Zara, Ana Laura de Sene Amâncio; Melo, Daniela Oliveira de; Simone, Adriane Lopes Medeiros
Vaccination and immunological profile for COVID-19: a cohort among pregnant women treated at two Basic Health Units in the state of Goiás, between 2021 and 2022
(2025) Borges, Diana de Lima; Zara, Ana Laura de Sene Amâncio; Souza, Jéssica Yonara de; Campos, Geovana Batista de; Castro, Ana Maria de
Objective: this study aimed to analyze the vaccination and immunological profile for COVID-19 in pregnant women treated at Basic Health Units in Goiânia, GO, Brazil, between May 2021 and July 2022. Methods: this is a prospective cohort study. The participants were selected by convenience, signed a consent form, answered a questionnaire, and had blood samples collected for anti-SARSCoV-2 (immunochromatography). This procedure was repeated up to three times throughout the pregnancy. After delivery, new samples were collected from the postpartum woman and the newborn for analysis. Results: the seroprevalence for IgG anti-SARS-CoV-2 among the 66 pregnant women monitored was 83.3%. It was ascertained that two or three doses of a COVID-19 vaccine produce a more effective immune response than just one dose. More than 75% of newborns presented SARSCoV-2 IgG antibodies. Conclusion: these data are relevant to encourage vaccination of pregnant women, following the complete vaccination schedule, and breastfeeding.
Mortalidade por causas externas em pessoas idosas no estado de Goiás, 2000-2021
(2025) Ribeiro, Ana Beatriz de Freitas; Oliveira, Max Moura de; Zara, Ana Laura de Sene Amâncio
Objective: To describe and analyze mortality from external causes among older adults in the state of Goiás, Brazil, between 2000 and 2021, and to compare the trend in mortality rates in the years prior to the pandemic (2000 to 2019) with the period that includes the first two years of the COVID-19 pandemic (2000 to 2021). Methods: An ecological study was conducted involving a time series analysis of mortality rates from external causes among older adults in Goiás, using data from the Mortality Information System. The Prais-Winsten regression model was used for trend analysis, with a 5% significance level. Results: A total of 19,049 older adults died from external causes in Goiás, of whom 12,468 (65.5%) were men; 6,290 (33%) were aged ≥80 years; 7,330 (38.5%) resided in the Central-West macro-region; and 8,717 (45.8%) died due to falls. The highest mortality rate in the state was recorded in 2018 (165.8/100,000) and the lowest in 2003 (112.5/100,000). Mortality rates from external causes exhibited an upward trend across all macro-regions in Goiás, particularly among individuals aged ≥70 years. When comparing trends that include the pandemic period, there was an increase in suicide mortality among men (p<0.05). Conclusion: Mortality from external causes among the older population in Goiás has been increasing, with falls being the leading cause, predominantly affecting men and individuals aged ≥80 years. The pandemic contributed to a rise in mortality from self-inflicted injuries/suicides. Actions focusing on surveillance and health promotion are necessary to mitigate this scenario and foster healthier aging.
Os efeitos da judicialização no orçamento da Secretaria Municipal de Saúde de Canguçu/RS
(2025) Cruz, Cristiano Manetti da; Provin, Mercia Pandolfo; Zara, Ana Laura de Sene Amâncio
Objectives: To identify expenses with the purchase of medicines and supplies by the Municipal Health Department of Canguçu/RS, through legal proceedings, from 2017 to 2021. Methods: It is a quantitative, descriptive, and retrospective study, using the document analysis technique. Secondary data on public costs, available on the Transparency Portal, were used. The amounts spent and the origins of the resources used for the acquisition of these drugs were analyzed. Results: There was an increase of 297.93% in spending on legal proceedings for the acquisition of medicines and pharmaceutical supplies through judicial blockades. Of these, more than 76% refer to antineoplastic medications. The basic care budget increased by 132.41% in this period and the costs of pharmaceutical assistance almost doubled from R$ 854,248.86, in 2017, to R$1,524,871.92, in 2021, with a significant increase during the pandemic period. Comparing the expenditure on purchasing medicines through blockages by court permits in 2021 and the amount spent on pharmaceutical assistance in the same period, it is noted that the cost is very similar, but a small portion of the population is served through judicialization. Conclusions: There was a considerable increase in spending on purchasing medicines due to court decisions. The Municipal Health Department is obliged to acquire medicines that do not belong to the Municipal Medication List, through judicial blocking of public accounts, because the government of the State of Rio Grande do Sul does not send these medicines to users with approved lawsuits.
Implantação do prontuário eletrônico do cidadão na atenção básica: relato de experiência
(2025) Lima, Flávio Henrique Alves de; Rodrigues Sobrinho , Felipe Bruno; Holdefer, Mariana Matias de Lima; Paula, Cácia Régia de; Cabral, Karynne Borges; Zara, Ana Laura Sene Amâncio
Objective: To report the experience of implementing and evaluating the implementation of the Electronic Citizen Record (PEC) and the e-SUS Strategy in a municipality in the interior of Goiás. Experience report: The experience took place between February 2022 and July 2023, made possible by the Digital Health Directorate that coordinated the initiative. Hardware and software diagnostics, training of health professionals and resolution of resistance were carried out, with technical support from PET-Saúde. Data were collected through user feedback and assessment of systems integration. The implementation of the PEC faced connectivity challenges and a lack of specific technical knowledge. These challenges were mitigated with the support of PET-Saúde and political awareness strategies. System integration and training improved clinical workflows and service efficiency, highlighting the positive impact of digital transformation on health management. Final considerations: The importance of collaboration between managers, teams and educational institutions for the success of digital transformation in healthcare is highlighted. Among the limitations, initial resistance and the continuous need for technical support stand out.
Envolvimento multidisciplinar na prevenção de infecção do trato urinário associada à cateter: revisão do escopo
(2025) Nascimento, Júlio César Coelho do; Almeida, Juliana Alves Moraes; Alves, Virgínia Farias; Santos, Silvana de Lima Vieira dos; Neves, Heliny Carneiro Cunha; Torres, Ieda Maria Sapateiro
Objective: Identify scientific evidence about the multidisciplinary teaminvolvement intheprevention of catheter-associated urinary tract infection in adult intensive care unit. Method: Scoping review on the databases Embase, Pubmed, Scopus, Cumulative Index to NursingandAllied Health Literature, and Virtual Health Library. Studies with patients admittedtoanadult intensive care unit and in use of urinary catheter, and that assessed multidisciplinaryintervention were included. Results: Nine studies were included, and most were level II ofscientific evidence. Infection reduction was related to bundles implementation, evaluationofcatheter insertion and maintenance, daily review of renewal or removal of the catheter, feedback to the intensive care unit health care team, and involvement of hospital managers. Conclusion: Strategies involving and that sensitize the health care multidisciplinar teamreduce the rate of catheter use and infection in adult intensive care unit.
Amazon acai and pineapple residues induce the enzyme laccase in pleurotus ostreatus: application to bisphenol a bioremediatio
(2025) Golveia, Jhessica Cavalcante de Souza; Nunes, Elaine Sousa; Bulhões, Thiago Souza; Oliveira Neto, Jerônimo Raimundo de; Cunha, Luiz Carlos da; Campos, Luiza Cintra; Santiago, Mariângela Fontes; Schimidt, Fernando
Bisphenol A (BPA), an endocrine disruptor used in different commercial polymers, is a persistent pollutant commonly found in effluents. Conventional wastewater treatment processes have low chemical removal efficiency and are expensive. This work evaluated BPA removal using laccase enzyme produced from white rot fungus Pleurotus ostreatus. For the enzymatic production, residues of acai berry and pineapple were used as laccase inducers. The use of natural inducers led to a high enzyme production (1139 and 1031 U mL-1 to acai and pineapple, respectively). Bisphenol A was removed to a concentration lower than LOD (limit of detection) after 4 h. The degradation mechanism of BPA occurred by oxidation of methyl to hydroxymethyl group in a propane portion, with breakdown of the aromatic ring. The developed technology brought to the scene a new green, viable methodology, using vegetable waste, adding value to these residues and bringing an alternative to the BPA treatment.
Associação entre o ambiente de trabalho de enfermeiros e uso de psicotrópicos: um estudo transversal
(2025) Gadelha, Nayara Siqueira Antunes; Lima , Dione Marçal; Martins, Karine Anusca
Objective:To analyze the relationship between the work environment and the use of psychotropic drugs by nurses. Methods:A cross-sectional analyticalstudy was conducted with 87 nurses from the Municipal Health Department of a city in the metropolitan region of Goiânia, Goiás. The data, collected remotely, covered sociodemographic and professional characteristics, dichotomization of the work environment as favorable or unfavorable to professional practice, mental health conditions, and use of psychotropic drugs. The data were analyzed using tests, descriptive analysis, reliability, and consistency. The analyses were considered statistically significant.Results:Among the participants, 32.2% used psychotropic drugs, 56.3% considered themselves anxious, 50% reported a diagnosis of anxiety, 70.5% considered work an important factor for this use, and 51.7% assessed the work environment as unfavorable to professional practice. Conclusion:The results suggest that nurses are potentially susceptible to the use of psychotropic drugs due to physical and mental exhaustion. The inappropriate and abusive use of these drugs can cause harm to nurses, patients, and health services. The nurses in the sample indicated that their work environment was unfavorable to professional practice and stated that work contributes to mental illness in the category, highlighting it as a relevant factor in the use of psychotropic drugs.This study offers important insights for reflection on the work environment as a risk factor for mental illness and reinforces the need to develop strategies for promoting, preventing, and protecting nurses' mental health.
Análise dos polimorfismos RS10750097 e RS3741298 dos genes da APOA5 em relação as dislipidemias
(2025) Saad, Fernanda Gabriel Aires; Campos, Luiza Moreno Cunha; Gomes, Clayson Moura; Castro, Frank Sousa; Costa, Sérgio Henrique Nascente
Análise da prevalência de dislipidemia em adolescentes atendidos em um laboratório escola
(2025) Almeida, Elisandra Cristina; Silva, Amanda Fonseca Andrade; Castro, Gabriela Gonçalves de; Santos, Thalyta Renata Araújo; Gomes, Clayson Moura; Costa, Sérgio Henrique Nascente
The objective of the study was to analyze the prevalence of dyslipidemias in adolescents attended at the school laboratory of a federal university. This is a retrospective study that used secondary data from tests comprising the lipid profile in patients aged 10 to 19 years from January to December 2023. A total of 612 adolescents were analyzed, with a prevalence of 54.7% dyslipidemic individuals, where about 32.3% had hypertriglyceridemia, 26.6% hypercholesterolemia, 25% had HDL levels below the desired, and 15.8% had increased LDL levels. The analysis of the results also showed higher lipid alterations in females (30.4%) than in males (24.3%). The high percentage of dyslipidemias in childhood and adolescence points to the need for effective public policies and strategies for prevention, early detection, and adequate treatment so that adverse effects related to cardiovascular diseases are minimized in the adult life of the population.
Laboratory analysis of patients infected with the dengue virus
(2025) Lima, Isadora Soares de; Alves, Ana Beatriz Belo; Sanches, Arthur Costa; Feitosa, Fernanda de Oliveira; Silva, Antonio Márcio Teodoro Cordeiro; Costa, Sérgio Henrique Nascente; Gomes, Clayson Moura
Objective: To analyze the laboratory data of patients infected with the dengue virus (DENV) in order to identify characteristic patterns associated with the infection. Methods: A cross-sectional retrospective study was conducted, evaluating secondary laboratory data from 2,117 patients treated at the Laboratory of the Military Police of the State of Goiás (LCHPM) between 2020 and 2022. Data from 389 patients who tested positive for DENV infection through NS1, IgM, and IgG assays were included. The following laboratory parameters were assessed: total leukocyte count, neutrophils, lymphocytes, platelet count, and the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and leukocyte-to-lymphocyte ratio (LLR). The study was approved by the Research Ethics Committee. Results: A total of 389 patients were diagnosed with dengue, showing significant alterations in platelet count (p<0.0001), leukocytes (p<0.0001), lymphocytes (p<0.0001), neutrophils (p<0.0001), and monocytes (p=0.0044), when compared with patients negative for infection. A marked increase in cases was observed in 2022, with a 330% rise between the fourth quarter of 2021 and the third quarter of 2022. Conclusion: The laboratory profile of the analyzed patients confirmed thrombocytopenia, leukocytosis, lymphopenia, monocytosis, elevated neutrophils, and hepatic alterations in infected patients, reinforcing the importance of laboratory and epidemiological analysis in the clinical management of dengue.
Aptidão física do policial militar do estado de Goiás
(2025) Moreira, Linda Denise Fernandes; Pires, Alexandre Tavares; Silva, Jéssica Oliveira da; Costa, Diony Dornélio da; Gomes, Clayson Moura; Costa, Sérgio Henrique Nascente; Castro, Milena Neves de

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