Antimicrobial activity of the crude ethanol extract from Hyptidendron canum leaves
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Data
2009
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Resumo
This study proposed to evaluate the antimicrobial activity of the crude ethanol extract of Hyptidendron
canum (Pohl ex Benth.) Harley (Lamiaceae) leaves. The crude ethanol extract was obtained from the dried,
pulverized leaves. The H. canum leaf powder was submitted to phytochemical screening. The antimicrobial
activity was evaluated against Gram-positive and -negative bacteria and Candida albicans using the well
diffusion test and the agar dilution method for determining the minimum inhibitory concentration (MIC).
Phytochemical screening showed the presence of flavonoid and saponinic heterosides. The extract demon strated antimicrobial activity against all microorganisms tested. The MIC for non-sporulated Gram-positive
bacteria varied from 4.37 to 17.5mg/mL. The sporulated Gram-positive bacteria tested had their growth
inhibited by H. canum (MIC from 4.37 to 35mg/mL). The MIC of H. canum for most of the Gram-negative
bacteria was 70mg/mL, except for Pseudomonas aeruginosa (MIC = 17.5mg/mL), at which concentration
C. albicans was also inhibited. This is the first report of phytochemical screening and antimicrobial activity
of H. canum.
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Flavonoids, Saponins, Llamiaceae, MIC
Citação
FIUZA, Tatiana de Sousa et al. Antimicrobial activity of the crude ethanol from Hyptidendron canum leaves. Pharmaceutical Biology, London, v. 47, n. 7, p. 640-644, 2009.