Elucidando a imunovigilância e imunoedição tumoral: uma revisão abrangente
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Data
2021-07-23
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
The action of the immune system against neoplastic diseases
has become one of the main sources of research. The biological
pathways of this system are known to contribute in limiting the
progression and elimination of the tumor, and are delineated
by concepts and mechanisms of immunosurveillance and
immunoediting. Immunosurveillance is considered the process
by which the immune system recognizes and inhibits the
neoplastic process. The concept of immunoediting arises in the
sense that immune system is able to shape the antigenic profile
of the tumor due to selective pressure, based on the stages of tumor elimination, balance and evasion. The immune response occurs
against tumor antigens and changes in the tumor microenvironment,
involving different components of the innate immune system, such
as T cells, natural Killer cells, B lymphocytes and macrophages.
In this sense, knowing these concepts and understanding their
respective mechanisms becomes essential in the investigation of new
strategies for cancer prevention and cure. Thus, this review presents
historical aspects and definitions of immunosurveillance and tumor
immunoediting, with emphasis on its importance and applicability,
such as on the different methods used in immunotherapy
Descrição
Palavras-chave
Imunocompetência, Imunologia tumoral, Imunoterapia, Progressão tumoral, Sistema imune
Citação
SILVA, Estela Vieira de Souza et al. Elucidando a imunovigilância e imunoedição tumoral: uma revisão abrangente. Ciência Animal Brasileira, Goiânia, v. 22, p. e-68544, jul. 2021. Disponível em: https://www.revistas.ufg.br/vet/article/view/6.