Pharmacoepidemiological profile and polypharmacy indicators in elderly outpatients
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2013-09
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Resumo
This cross-sectional study was carried out with 1000 elderly outpatients assisted by a Basic Health District
Unit (UBDS) from the Brazilian Public Health System (SUS) in the municipality of Ribeirão Preto.
We analyzed the clinical, socioeconomic and pharmacoepidemiological profile of the elderly patients
in order to identify factors associated with polypharmacy amongst this population. We used a truncated
negative binomial model to examine the association of polypharmacy with the independent variables of
the study. The software SAS was used for the statistical analysis and the significance level adopted was
0.05. The most prevalent drugs were those for the cardiovascular system (83.4%). There was a mean
use of seven drugs per patient and 47.9% of the interviewees used ≥7 drugs. The variables that showed
association with polypharmacy (P value < 0.01) were female gender, age >75 years, self-medication,
number of health problems, number of medical appointments, presence of adverse drug events, use of
over-the-counter drugs, use of psychotropic drugs, lack of physical exercise and use of sweeteners. The
exposition to all these factors justified the high prevalence of polypharmacy amongst the interviewees.
These results showed the need to adopt clinical intervention and educational and managerial measures
to analyze and promote rationality in the use of drugs amongst the elderly users of SUS
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Palavras-chave
Pharmacoepidemiology, Public health system, Elderly/use of drugs, Polypharmacy, Drugs/rational use, Farmacoepidemiologia, Idoso/uso de medicamentos, Sistema público de saúde, Polifarmácia, Medicamentos/uso racional
Citação
BALDONI, André de Oliveira et al. Pharmacoepidemiological profile and polypharmacy indicators in elderly outpatients. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 49, n. 3, p. 443-452, July/Sept. 2013.