Triterpenes from Minquartia guianensis (Olacaceae) and in vitro antimalarial activity
Carregando...
Data
2012
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Minquartia guianensis, popularly known as acariquara, was phytochemically investigated. The following triterpenes were isolated
from the dichloromethane extract of leaves: lupen-3-one (1), taraxer-3-one (2) and oleanolic acid (3). The dichloromethane extract
of branches yielded the triterpene 3β-methoxy-lup-20(29)-ene (4). The chemical structures were characterized by NMR data. Plant
extracts, substance 3, squalene (5) and taraxerol (6), (5 and 6 previously isolated), were evaluated by in vitro assay against chloroquine
resistant Plasmodium falciparum. The dichloromethane extract of leaves and the three triterpenes assayed have shown partial activity.
Thus, these results demonstrated that new potential antimalarial natural products can be found even in partially active extracts
Descrição
Palavras-chave
Minquartia guianensis, Plasmodium falciparum, Triterpenes
Citação
CURSINO, Lorena Mayara de Carvalho et al. Triterpenes from Minquartia guianensis (Olacaceae) and in vitro antimalarial activity. Química Nova, São Paulo, v. 35, n. 11, p. 2165-2168, 2012.