Development of lamellar gel phase emulsion containing baru oil (Dipteryx alata Vog.) as a prospective delivery system for cutaneous application
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2018
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The rational design of emulsions requires study of the main factors that influence their formation,
physicochemical properties and, consequently, stability and performance. The use
of vegetable oils in the pharmaceutical and cosmetic industries has recently become attractive.
Dipteryx alata Vogel (D. alata) is an oleaginous species native to Brazil. The seeds of
this species contain highly unsaturated oil with significant amounts of tocopherols and phytosterols,
representing an important source of agents capable of combatting oxidative
processes. In this work, a lamellar gel phase emulsion using oil extracted from the seeds
of D. alata (baru) was developed.The steps involved in the development of this research were
as follows: 1) development of formulations and 2) in vitro assays by simulating the evaporation
of the final product after application to the skin and Electron paramagnetic resonance
spectroscopy (EPR) of fatty acid spin labels was used to investigate the profile of interaction
of the dispersed systems with stratum corneum (SC) lipids. The results indicate that the
developed system shows no signs of instability during the storage period. Moreover, EPR
studies indicated that D. alata oil and especially the developed formulation were able to increase
SC lipid fluidity and extract a fatty-acid spin label from the lipid domain structures
of SC, demonstrating its potential to act as a drug or skin care vehicle.
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Stratum corneum, EPR spectroscopy, O/W emulsions, Baru oil
Citação
MORAES, Cristhianne; ANJOS, Jorge L. V.; MARUNO, Monica; ALONSO, Antonio; ROCHA-FILHO, Pedro. Development of lamellar gel phase emulsion containing baru oil ( dipteryx alata vog.) as a prospective delivery system for cutaneous application. Asian Journal of Pharmaceutical Sciences, Hong Kong, v. 13, n. 2, p. 183-190, 2018, 2017. DOI: 10.1016/j.ajps.2017.09.003. Disponível em: https://www.sciencedirect.com/science/article/pii/S1818087617304142?via%3Dihub. Acesso em: 14 abr. 2023.