Presence of maternal anti-HBs antibodies does not influence hepatitis B vaccine response in brazilian neonates

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dc.creatorJunqueira, Ana Luiza Neto
dc.creatorTavares, Viviane Rodrigues
dc.creatorMartins, Regina Maria Bringel
dc.creatorAlexandre, Kamilla Venâncio Frauzino
dc.creatorSilva, Agabo Macedo da Costa e
dc.creatorRodrigues, Izolina Maria Xavier
dc.creatorMinamisava, Ruth
dc.creatorTeles, Sheila Araújo
dc.date.accessioned2018-10-03T11:48:26Z
dc.date.available2018-10-03T11:48:26Z
dc.date.issued2011-02
dc.description.abstractRecently, it was suggested that maternal hepatitis B surface antigen antibodies (anti-HBs) acquired transplacentally could play a negative role in newborn infants’ immune response to the hepatitis B vaccine. We compared the hepatitis B virus (HBV) vaccine response in infants born to mothers previously vaccinated against HBV (n = 91) to infants born to mothers who were not previously vaccinated (n = 221). All newborn infants received three intramuscular doses (10 μg) of HBV vaccine (Butang®) at 0,1 and six months. The first dose was administered at the maternity hospital within 12 h of birth. The geometric mean titres of anti-HBs were not different among newborn infants born to mothers who were anti-HBs-negative (492.7 mIU/mL) and anti-HBs-positive (578.7 mIU/mL) (p = 0.38). Eight infants did not respond to the HBV vaccine. Of them, six were born to anti-HBs-negative mothers and two were born to mothers with anti-HBs titres less than 50 mlU/mL. Despite the mother’s anti-HBs-positive status, our data show a good immunogenicity of the Brazilian HBV recombinant vaccine in neonates.pt_BR
dc.identifier.citationJUNQUEIRA, Ana Luiza N. et al. Presence of maternal anti-HBs antibodies does not influence hepatitis B vaccine response in brazilian neonates. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 1, p. 113-116, Feb. 2011.pt_BR
dc.identifier.doi10.1590/S0074-02762011000100018
dc.identifier.issne- 1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16099
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Enfermagem - FEN (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHepatitis B vaccinept_BR
dc.subjectNewborn infantspt_BR
dc.subjectAntibody responsept_BR
dc.titlePresence of maternal anti-HBs antibodies does not influence hepatitis B vaccine response in brazilian neonatespt_BR
dc.typeArtigopt_BR

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