How much are metals for next-generation clean technologies harmful to aquatic animal health? A study with cobalt and nickel effects in zebrafish (Danio rerio)
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2022-11
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Cobalt (Co) and nickel (Ni) are key metals for next-generation clean technologies with broad applications in
industrial, military and commercial products. However, the knowledge about their environmental impact and
toxicity to aquatic organisms remain limited, especially for the early developmental stages of fish. Thus, the
current study aimed to evaluate the developmental toxicity of Co and Ni in zebrafish (Danio rerio). Zebrafish
embryo-larval toxicity test (ZELT) was conducted with Co and Ni at different concentrations (10, 20, 40, 60,
80 and 100 mg L−1) during 144 h in a static condition. Multiple biomarker responses were analyzed, such as
mortality, hatching rate, neurotoxicity, cardiotoxicity, teratogenesis, and morphometric changes. Results showed
high embryotoxicity of Ni compared to Co. Both metals inhibited the hatching process and induced morphological changes, such as inhibition of swim bladder inflation, yolk sac edema and pericardial edema. Co induced
bradycardia in zebrafish embryos, while Ni caused tachycardia, indicating differential cardiotoxic effects. Overall, the exposure to Co and Ni disrupts early development of zebrafish, confirming their risk to the health of
freshwater fish. Results indicated the ZELT as a suitable approach to assess the environmental risk of metals for
next-generation clean technologies.
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Embryotoxicity, Aquatic toxicity, Environmental pollution, Biomarkers, Model system, Fish
Citação
ALVES, Andreia Cristina Fonseca et al. How much are metals for next-generation clean technologies harmful to aquatic animal health? A study with cobalt and nickel effects in zebrafish (Danio rerio). Journal of Hazardous Materials Advances, [s. l.], v. 8, e100160, 2022. DOI: 10.1016/j.hazadv.2022.100160. Disponível em: https://www.sciencedirect.com/science/article/pii/S2772416622001164. Acesso em: 28 jan. 2025.