Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow
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2017
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The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP,
which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments
were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/
kg bw with 4 mg/kg bw MMC or 50 mg/kg bw CP. Second, the mutagenic drug (CP) was administered
ip 50 mg/kg bw and after 6 and 12 hours 250 and 500 mg/kg bw of C. guianensis oil were administered.
In the last, C. guianensis oil was administrated (250 and 500 mg/kg bw) during five days and after it was
administered ip 50 mg/kg bw CP. The results obtained showed that the C. guianensis oil is not cytotoxic
neither genotoxic to mouse bone marrow. Regarding the antimutagenic effect, all doses of C. guianensis
oil were significantly (p < 0.05) effective in reducing the frequency of micronucleated polychromatic
erythrocytes, when compared with MMC or CP alone. Based on these results, our results suggest that
the C. guianensis oil shows medicinal potential as an antimutagenic agent, modulating the mutagenicity
caused by both direct- and indirect-acting chemical mutagens, in a mammalian model.
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Antigenotoxic, Micronucleus, Oil, Carapa guianensis
Citação
LEMES, Susy R. et al. Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 89, n. 3, p. 2043-2051, 2017. Suplemento. DOI: 10.1590/0001-3765201720150797. Disponível em: https://www.scielo.br/j/aabc/a/9D8J6xSQhTVtGHzKcKrLWSv/?lang=en. Acesso em: 5 mio 2023.