Validation of a rapid and reliable test for diagnosis of Chagas´disease by detection of Trypanosoma cruzi-specific antibodies in blood of donors and patients in Central America

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dc.creatorPonce, Carlos
dc.creatorPonce, Elisa
dc.creatorVinelli, Elizabeth
dc.creatorMontoya, Alberto
dc.creatorAguilar, Vilma de
dc.creatorGonzalez, Antonio
dc.creatorZingales, Bianca
dc.creatorRangel-Aldão, Rafael
dc.creatorLevin, Mariano Jorge
dc.creatorEsfandiari, Javan
dc.creatorUmezawa, Eufrosina Setsu
dc.creatorOstermayer, Alejandro Luquetti
dc.creatorSilveira, José Franco da
dc.date.accessioned2018-04-25T15:09:11Z
dc.date.available2018-04-25T15:09:11Z
dc.date.issued2005-10
dc.description.abstractIn this study we compared the performance of the Chagas Stat-Pak rapid immunochromatographic test with a standard enzyme-linked immunosorbent assay (ELISA) in the serodiagnosis of Chagas’ disease in Central America. Out of 3,400 blood donor samples, 156 (4.6%) were positive in both assays. Three sera out of 2,084 samples from reference laboratories were negative with the rapid test but positive with the ELISA (99.8% agreement). Agreement of 100% between the two tests was observed with 339 additional sera from patients with cardiopathies and 175 sera from potential blood donors in emergency surgical cases occurring on weekends or at night. In conclusion, Chagas Stat-Pak showed 99.6% and 99.9% sensitivity and specificity, respectively, when assayed with 5,998 serum samples. It is a sensitive and specific alternative to the ELISA, as required in medical emergencies and blood screenings in Central America.pt_BR
dc.identifier.citationPONCE, Carlos; PONCE, Elisa; VINELLI, Elizabeth; MONTOYA, Alberto; AGUILAR, Vilma de; GONZALEZ, Antônio; ZINGALES, Bianca; RANGEL-ALDÃO, Rafael; LEVIN, Mariano J.; ESFANDIARI, Javan; UMEZAWA, Eufrosina S.; LUQUETTI, Alejandro O.; SILVEIRA, José Franco da. Validation of a rapid and reliable test for diagnosis of Chagas´disease by detection of Trypanosoma cruzi-specific antibodies in blood of donors and patients in Central America. Journal of Clinical Microbiology, Washington, v. 43, n. 10, p. 5065-5068, Oct. 2005.pt_BR
dc.identifier.doi10.1128/JCM.43.10.5065–5068.2005
dc.identifier.issn0095-1137
dc.identifier.issne- 1098-660X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/14655
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectTest for diagnosispt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectChagas diseasept_BR
dc.subjectAntibodies in bloodpt_BR
dc.titleValidation of a rapid and reliable test for diagnosis of Chagas´disease by detection of Trypanosoma cruzi-specific antibodies in blood of donors and patients in Central Americapt_BR
dc.typeArtigopt_BR

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