Diagnóstico fotodinâmico: princípios e aplicações
Carregando...
Data
2015-12
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
In recent years, the use of fluorescence-based techniques has greatly increased.
However, the use of such techniques in Veterinary Medicine is not widespread.
Considering the need for further information on the use of these techniques to assist
the diagnosis of diseases, the objective of this review was to cover the main
applications of photodiagnosis as well as the photosensitizers more used in this
process. Photodynamic diagnosis is based on the manner in which normal and
abnormal tissues absorb light, allowing fluorescence on these tissues when they are
in contact with a fluorophore. These fluorophores may be endogenous or exogenous,
and emit fluorescence when excited by light of a specific wavelength. The
fluorophores are called exogenous photosensitizers and have a key role in
photodiagnosis. They are molecules capable of interacting with light-generating
fluorescence or reactive oxygen species. This technique can be applied to the
diagnosis of many diseases, such as skin fungi, detection of dental caries, bacterial
biofilms, detection of small lesions in the digestive tract, and especially in the early
diagnosis of cancer and treatment of neoplasms. Being an innovative non-invasive
technique, with high sensitivity and specificity, as well as relatively quick and easy to
perform, photodynamic diagnosis presents potential for use in veterinary medicine.
Descrição
Palavras-chave
Fotodiagnóstico, Fotossensibilizadores, Fluorescência, Porfirina, Photodiagnosis, Photosensitizers, Fluorescence, Porphyrin
Citação
OLIVEIRA, Taise Maria dos Anjos et al. Diagnóstico fotodinâmico: princípios e aplicações. Enciclopédia Biosfera, Goiânia, v. 11, n. 22, p. 976-1000, dez. 2015.