Spatio-temporal image correlation analysis for 3D flow field mapping in microfluidic devices

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dc.creatorCeffa, Nicolò Giovanni
dc.creatorBouzin, Margaux
dc.creatorD'Alfonso, Laura
dc.creatorSironi, Laura
dc.creatorMarquezin, Cassia Alessandra
dc.creatorAuricchio, Ferdinando
dc.creatorMarconi, Stefania
dc.creatorChirico, Giuseppe
dc.creatorCollini, Maddalena
dc.date.accessioned2023-12-06T12:31:13Z
dc.date.available2023-12-06T12:31:13Z
dc.date.issued2017
dc.description.abstractMicrofluidic devices reproducing 3D networksare particularly valuable for nanomedicine applications such astissue engineering and active cell sorting. There is however agap in the possibility to measure how theflow evolves in such3D structures. We show here that it is possible to map 3Dflows in complex microchannel networks by combining widefield illumination to image correlation approaches. For thispurpose, we have derived the spatiotemporal image correlationanalysis of time stacks of single-plane illumination microscopyimages. From the detailed analytical and numerical analysis ofthe resulting model, we developed afitting method that allowsus to measure, besides the in-plane velocity, the out-of-plane velocity component down tovz≅65μm/s. We have applied thismethod successfully to the 3D reconstruction offlows in microchannel networks with planar and 3D ramifications. Thesedifferent network architectures have been realized by exploiting the great prototyping ability of a 3D printer, whose precision canreach few tens of micrometers, coupled to poly dimethyl-siloxane soft-printing lithography.
dc.identifier.citationCEFFA, Nicolo’ G. et al. Spatio-temporal image correlation analysis for 3D flow field mapping in microfluidic devices. Analytical Chemistry, Washington, v. 90, n. 3, p. 2277-2284, 2017. DOI: 10.1021/acs.analchem.7b04641. Disponível em: https://pubs.acs.org/doi/10.1021/acs.analchem.7b04641. Acesso em: 14 set. 2023.
dc.identifier.doi10.1021/acs.analchem.7b04641
dc.identifier.issn0003-2700
dc.identifier.issne- 1520-6882
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.analchem.7b04641
dc.language.isoeng
dc.publisher.countryEstados unidos
dc.publisher.departmentInstituto de Física - IF (RMG)
dc.rightsAcesso Restrito
dc.titleSpatio-temporal image correlation analysis for 3D flow field mapping in microfluidic devices
dc.typeArtigo

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