Electrochemical remediation of amoxicillin: detoxification and reduction of antimicrobial activity

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dc.creatorBrito, Lara Barroso
dc.creatorGarcia, Luane Ferreira
dc.creatorCaetano, Marcos Pereira
dc.creatorSanz Lobón, Germán
dc.creatorOliveira, Mayk Teles de
dc.creatorOliveira, Rhaul de
dc.creatorTorres, Ieda Maria Sapateiro
dc.creatorVaz, Boniek Gontijo
dc.creatorValadares, Marize Campos
dc.creatorGil, Eric de Souza
dc.creatorOliveira, Gisele Augusto Rodrigues de
dc.date.accessioned2023-08-03T15:28:54Z
dc.date.available2023-08-03T15:28:54Z
dc.date.issued2018
dc.description.abstractAmoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world to treat and prevent several diseases in both human and veterinary medicine. Incomplete removal of AMX during wastewater treatment contributes to its presence in water bodies and drinking water. AMX is an emerging contaminant since its impact on the environment and human health remains uncertain. This contribution was aimed to evaluate the electrochemical oxidation (EO) of AMX using different anodes in tap water, NaCl or Na2SO4 solutions and to evaluate the potential toxicity of remaining AMX and its by-products on zebrafish early-life stages. Chemical intermediates generated after EO were determined by mass spectrometry and their resulting antimicrobial activity was evaluated. AMX did not induce significant mortality in zebrafish during extended exposure but affected zebrafish development (increased body length) from 6.25 mg/L to 25 mg/L and inhibited enzymatic biomarkers. Carbon modified with titanium oxide (TiO2@C) anode achieved complete AMX removal in just a few minutes and efficiency of the supported electrolytes occurred in the following order: 0.1 M NaCl > 0.1 M Na2SO4 > 0.01 M NaCl > tap water. The order of potential toxicity to zebrafish early life-stages related to lethal and sublethal effects was as follows: 0.1 M Na2SO4 > 0.1 M NaCl >0.01 M NaCl = tap water. Additionally, the EO of AMX using TiO2@C electrode with 0.01 M NaCl was able to inhibit the antimicrobial activity of AMX, reducing the possibility of developing bacterial resistance.pt_BR
dc.identifier.citationBRITO, Lara Barroso et al. Electrochemical remediation of amoxicillin: detoxification and reduction of antimicrobial activity. Chemico-Biological Interactions, Amsterdam, v. 291, p. 162-170, 2018. DOI: 10.1016/j.cbi.2018.06.017. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0009279718301753?via%3Dihub. Acesso em: 28 jun. 2023.pt_BR
dc.identifier.doi10.1016/j.cbi.2018.06.017
dc.identifier.issne- 1872-7786
dc.identifier.issn0009-2797
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0009279718301753?via%3Dihub
dc.language.isoengpt_BR
dc.publisher.countryHolandapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleElectrochemical remediation of amoxicillin: detoxification and reduction of antimicrobial activitypt_BR
dc.typeArtigopt_BR

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