Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles
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2017
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Magnetic nanoparticles dissipate heat when exposed to alternating magnetic fields (AMFs),
making them suitable for cancer hyperthermia. Therapeutic heating applications demand accurate
characterization of the heating power dissipated by the particles. Specific loss power (SLP) generated
by magnetic nanoparticles is estimated from calorimetric heating measurements. Such measurements
require adiabatic conditions, yet they are typically performed in an AMF device with non-adiabatic
conditions. We have measured heating from four magnetic nanoparticle constructs using a range of
frequencies (150–375 kHz) and magnetic fields (4–44 kA/m). We have extended a method developed to
estimate SLP from the inherently non-adiabatic measurements, where we identify data ranges that
conform to (quasi)-adiabatic conditions. Each time interval of measurement that met a predetermined
criterion was used to generate a value of SLP, and the mean from all estimates was selected as the
estimated SLP. Despite the application of rigorous selection criteria, measured temperature data
displayed variability at specific heating loads resulting in larger variance of calculated mean SLP values.
Overall, the results show a linear dependence of the SLP with AMF frequency, as anticipated by current
models. Conversely, measured amplitude-dependent SLP profiles of all studied constructs conform to
no predictions of current models.
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SOETAERT, Frederik; KANDALA, Sri Kamal; BAKUZIS, Andris; IVKOV, Robert. Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles. Scientific Reports, San Francisco, v. 7, e6661, 2017. DOI: 10.1038/s41598-017-07088-w. Disponível em: https://www-ncbi-nlm-nih.ez49.periodicos.capes.gov.br/pmc/articles/PMC5532265/pdf/41598_2017_Article_7088.pdf. Acesso em: 11 abr. 2023.