Electrochemical behavior and determination of fluconazole
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Data
2011
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Resumo
The electrochemical behavior of fluconazole showed an irreversible oxidation process, with
the electrochemical - chemical mechanism being highly dependent on the electrode material.
Adsorption of reagent at positive applied potential was observed at Pt electrode while preferential
adsorption of the oxidation products was observed at Glassy Carbon surfaces. In pH below 7.0,
the anodic current process was intensively decreased. At carbon paste electrode, the fluconazole
oxidation current, recorded in phosphate buffer solution (pH 8.0), changed linearly with the
fluconazole concentration, Ipa = 5.7×10-5 (mA) × 0.052 [Fluconazol] (μg mL-1), in the range of
48.0 to 250.0 μg mL-1. The detection limit obtained was 6.3 μg mL-1.
Descrição
Palavras-chave
Fluconazole, Electrodic material, Electrochemical behavior, Vltammetry
Citação
GIL, Eric de S. et al . Electrochemical behavior and determination of fluconazole. Journal of the Brazilian Chemical Society, São Paulo, v. 22, n. 4, p. 767-771, 2011.