In vitro, ex vivo and in vivo models: a comparative analysis of Paracoccidioides spp. proteomic studies
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2018
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Resumo
Members of the Paracoccidioides complex are human pathogens that infect different anatomic sites in the
host. The ability of Paracoccidioides spp. to infect host niches is putatively supported by a wide range of
virulence factors, as well as fitness attributes that may comprise the transition from mycelia/conidia to
yeast cells, response to deprivation of micronutrients in the host, expression of adhesins on the cell
surface, response to oxidative and nitrosative stresses, as well as the secretion of hydrolytic enzymes in
the host tissue. Our understanding of how those molecules can contribute to the infection establishment
has been increasing significantly, through the utilization of several models, including in vitro, ex vivo and
in vivo infection in animal models. In this review we present an update of our understanding on the
strategies used by the pathogen to establish infection. Our results were obtained through a comparative
proteomic analysis of Paracoccidioides spp. in models of infection
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Hostepathogen interaction, Paracoccidioides, Proteome, Virulence factor
Citação
PARENTE-ROCHA, Juliana Alves et al. In vitro, ex vivo and in vivo models: a comparative analysis of Paracoccidioides spp. proteomic studies. Fungal Biology, Amsterdam, v. 122, n. 6, p. 505-513, 2017. DOI: 10.1016/j.funbio.2017.10.009. Disponível em: https://www.sciencedirect.com/science/article/pii/S1878614617301460?via%3Dihub. Acesso em: 9 ago. 2024.