Alterações morfológicas do sistema nervoso central induzidas em camundongos por Trypanosoma cruzi
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Data
2008
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Resumo
Children up to four years old are most susceptible to infection by
Trypanosoma cruzi, which can compromise the central nervous system. The objective of this study
was to quantify body weight, evaluate the histological alterations in the nervous system of 10-
day-old mice inoculated with 4.000 or 20.000 trypomastigotes of T. cruzi , and also study the
parasitemia of the inoculated animals at 25 days of age, with and without immunosuppression.
The animals were sacrificed and fixed with 4% paraformaldehyde. Encephalic and medullar
fragments were processed using the histological technique and stained with hematoxilin-eosin.
Parasitemia was major in inoculated and immunosuppressed animals. Inoculated animals
presented lower body weight than controls. In the encephalon, amastigote nests, glial nodes and
perivascular infiltrates were found. In the medulla, no histological alterations were. Young
animals were more susceptible to T. cruzi infection, with more severe encephalic implications.
The studied isolate presented behavior compatible with type III strains.
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Palavras-chave
Trypanosoma cruzi, Central nervous system, Chagas’ disease, Trypanosoma cruzi, Doença de Chagas, Sistema nervoso central
Citação
MATA, Fabiana Ribeiro da et al. Alterações morfológicas do sistema nervoso central induzidas em camundongos por Trypanosoma cruzi. Acta Scientiarum. Health Sciences, Maringá, v. 30, n. 1, p. 41-45, 2008.