Synthesis, characterization and evaluation of in vitro antitumor activities of novel chalcone-quinolinone hybrid compounds
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2018
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Resumo
Chalcone-quinolinone hybrid compounds, as well as the synthesis of such compounds, have
few reports in the literature. Such compounds may be quite useful in therapeutics, since various
biological activities are reported for both chalcones and quinolinones. In the present work, several
novel chalcone-quinolinone compounds have been synthesized. The reaction conditions developed
allowed to obtain the compounds in a single step of synthesis from the chalcones. The products
precipitated pure and were isolated by filtration. The yields of such reactions, from 45 to 94%,
were promising. The product structures were confirmed by nuclear magnetic resonance (NMR)
and electrospray ionization mass spectrometry (ESI-MS) techniques. Their antitumor activities
were evaluated in HCT-116 (colon) cell lines by the 3-(4,5-dimethyl-2-thiazole)-2,5-diphenyl2-H-tetrazolium bromide (MTT) test. The half maximal inhibitory concentration (IC50) values
obtained for the most active chalcones were between 2.9 and 7.5 and for active quinolinone was
19.3 mg L-1. The antitumor activities results suggest that the class of compounds studied has
potential for use in cancer research.
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Chalcone-quinolinone hybrids, Chacone sulfonamide, Claisen-Schmidt condensation, Antitumor activity
Citação
D’OLIVEIRA, Giulio D. C. et al. Synthesis, characterization and evaluation of in vitro antitumor activities of novel chalcone-quinolinone hybrid compounds. Journal of the Brazilian Chemical Society, Campinas, v. 29, n. 11, p. 2308-2325, 2018. DOI: 10.21577/0103-5053.20180108. Disponível em: https://jbcs.sbq.org.br/default.asp?ed=278. Acesso em: 17 ago. 2023.