Restrict access material for paper spray ionization mass spectrometry: a versatile tool for catecholamines and antidepressants determination in plasma samples

Abstract

In the present study, a fast, accurate and reliable mass spectrometry methodology without any sample pretreatment step and low solvent consumption for catecholamines and antidepressants determination in plasma samples is reported. An internal surface reversed-phase restrict access material was synthesized onto a paper surface and applied to the extraction of dopamine, epinephrine, diazepam, nortriptyline, and fluoxetine from human plasma following direct desorption by paper spray mass spectrometry (PSI-MS). The developed methodology showed to be accurate, precise and linear in a concentration range from the limit of quantification to 1000 ng mL−1. The limits of quantification for all analytes ranged from 1.4 to 5.3 ng mL−1. According to the results, the developed methodology could be a powerful tool for drug levels monitoring in clinical or urgent care.