Risk factors for potentially inappropriate medication use in older adults: a cohort study

Araújo, Natacha Christina de; Silveira, Erika Aparecida da; Mota, Brenda Godoi; Guimarães, Rafael Alves; Modesto, Ana Carolina Figueiredo

Risk factors for potentially inappropriate medication use in older adults: a cohort study

Data

2022

Autores

Araújo, Natacha Christina de

Silveira, Erika Aparecida da

Mota, Brenda Godoi

Guimarães, Rafael Alves

Modesto, Ana Carolina Figueiredo

Resumo

Background Much of the knowledge on the use of potentially inappropriate medications (PIM) in older adults is derived from cross-sectional studies, with little known about the risk factors over time. Aim Longitudinal analysis was applied to estimate the occurrence and risk factors of PIM use among older adults in a 10-year follow-up. Method Longitudinal study with 418 older adult residents of a capital city of Central-West Brazil. The PIM were classifed according to the Beers criteria 2019. The usage rate was calculated at baseline (2008) and at the 10-year follow-up moment (2018). Analysis of predictors (sociodemographic, self-rated health, hospitalization, number of comorbidities, polypharmacy, diabetes, hypertension, hypercholesterolemia and nutritional status) was performed using Generalized Estimating Equation (GEE) models. Results Mean age at baseline was 70.6 years (SD 7.1) and 76% were women; 221 older adults took part in the follow up. The rate of PIM use was 50.4% at baseline and 57.5% at the 10-year follow-up. Multiple analysis showed that PIM use in the cohort was statistically higher in the older adults with a history of hospitalization (RRadj 1.20; 95% CI 1.01–1.40), with three or more diseases (RRadj 1.41; 95% CI 1.14–1.74), with polypharmacy (RRadj 1.81; 95% CI 1.47–2.24) and with diabetes mellitus (RRadj 1.24; 95% CI 1.05–1.47). Conclusion A high level of potentially inappropriate medication use was observed, reaching 50% of the older adults, with a 7% increase in the prevalence over the 10-year follow-up period. Hospitalization, multimorbidities, polypharmacy and diabetes mellitus were associated with the use of these medications. Interventions for surveillance of the deprescribing process need to be encouraged to avoid potential harm caused by the use of medications.

Palavras-chave

Cohort study, Hospitalization, Multimorbidities, Polypharmacy, Potentially inappropriate medication

Citação

ARAÚJO, Natacha Christina de et al. Risk factors for potentially inappropriate medication use in older adults: a cohort study. International Journal of Clinical Pharmacy, Dordrecht, v. 44, p. 1132-1139, 2022. DOI: 10.1007/s11096-022-01433-4. Disponível em: https://link.springer.com/article/10.1007/s11096-022-01433-4. Acesso em: 1 abr. 2025.