Estudo e compreensão da disbiose cutânea induzida pelo uso de antimicrobianos: implicações na homeostase da pele e a relação com a dermatite atópica

Abstract

The human skin harbors a diverse microbiota that plays an essential role in maintaining skin integrity. Excessive or prolonged use of antimicrobials, such as antibiotics, can destabilize this microbiota, resulting in an imbalance known as dysbiosis. This condition compromises the skin barrier and exacerbates inflammatory responses, contributing to the onset and worsening of AD. Current therapeutic approaches for AD prioritize symptom management but often fail to address the preservation or restoration of the microbiota. Promising strategies, such as the use of topical probiotics and postbiotics, have shown potential in promoting microbial balance and improving skin health. This study investigates the relationship between the use of antimicrobials and skin dysbiosis, as well as its implications for the development and worsening of atopic dermatitis (AD). A literature review was conducted in scientific databases such as PubMed, Scopus, and SciELO, using descriptors and inclusion criteria.