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Item Preparo de micropartículas lipídicas de cera de carnaúba como estratégia tecnológica visando o mascaramento de sabor desagradável de fármacos hidrossolúveis(Universidade Federal de Goiás, 2025-06-06) Tavares, Layla Lopes; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Pascoa, Henrique; Freitas, Leticia Silva OliveiraThe bitter taste present in many drugs can compromise therapeutic adherence, especially among children and the elderly, as the unpleasant flavor can make medication administration more difficult. Therefore, taste masking becomes a viable strategy to improve treatment adherence and acceptance, and consequently, the quality of the pharmaceutical product. In this context, the present study aimed to develop microparticulate systems as a lipid-based platform for masking the unpleasant taste of water-soluble drugs. Carnauba wax was used as the lipid excipient, and the frozen emulsion method was employed as the taste-masking technique. The method was based on the preparation of two immiscible phases: a lipid phase, composed of carnauba wax and dipyrone, and an aqueous phase, consisting of Milli-Q water and the surfactant Tween 80. The aqueous phase was heated to 90 °C on a heating plate under stirring with a mechanical agitator, and once this temperature was reached, the lipid phase was melted on a separate heating plate. Subsequently, the lipid phase was poured into the aqueous phase under stirring. Two different homogenization methods were tested during this step: (i) using an Ultra-Turrax operating at 10,000 rpm for 1 minute, and (ii) a mechanical agitator A-20 operating at 3,500 rpm for 1 minute. After homogenization, cold water was added to the dispersion, which was stirred again for 1 minute. Finally, the mixture was kept under magnetic stirring for an additional 15 minutes. The microparticles obtained were characterized in terms of morphology, using stereomicroscopy and optical microscopy, and in terms of particle size distribution, using a sieve shaker. The microparticles produced with the Ultra-Turrax showed predominantly spherical morphology but exhibited a widely divergent bimodal size distribution, with higher concentrations retained in the 600 μm and 45 μm sieves. In contrast, the microparticles obtained using the A-20 mechanical agitator displayed less spherical morphology, but a more consistent bimodal size distribution, with concentrations in the 150 μm and 45 μm sieves. Thus, although carnauba wax and the frozen emulsion method proved effective in forming microparticulate systems, further testing is necessary to improve the uniformity and sphericity of the microparticles.Item Atividade leishmanicida do nerolidol e de um surfactante: associação com rigidez de membrana em Leishmania amazonensis e macrófagos infectados(Universidade Federal de Goiás, 2025-06-06) Crosara, Nathalia Fogaça dos Santos; Borges, Ellyêssa do Nascimento; Alonso, Antônio; Alonso, Antônio; Marquezin, Cássia Alessandra; Silva, Kleber Santiago Freitas eLeishmaniasis is a neglected parasitic disease that affects millions of people, especially in tropical regions such as Brazil. Transmitted by sand flies, currently available treatments have important limitations, such as high toxicity, high cost and increased parasite resistance. In view of this scenario, the leishmanicidal effects of nerolidol, a natural sesquiterpene, and the zwitterionic surfactant HPS (N-hexadecyl-N,N-dimethyl-3-ammonium-1-propanesulfonate) against Leishmania amazonensis were investigated. Using the electron paramagnetic resonance (EPR) spectroscopy of spin labeling, it was found that both compounds altered the fluidity of the parasite's plasma membrane, promoting an initial increase followed by rigidity after 24 h of exposure. IC50 values ??were estimated at approximately 74 ?M for nerolidol and 10 ?M for HPS. At concentrations ranging from one to three times their respective IC50 values, they induced significant membrane stiffness, attributed to the formation of reactive oxygen species (ROS), with consequent lipid peroxidation and/or protein oxidation. In uninfected J774A.1 macrophages, no membrane stiffening was observed, possibly due to the protective action of endogenous nitric oxide, capable of neutralizing oxidative stress. On the other hand, in macrophages previously infected with Leishmania, there was an increase in membrane stiffness after 72 h of treatment, suggesting that the infection sensitizes these cells to oxidative damage. To complement the evaluation of the selectivity and safety of the compounds, their cytotoxicity in macrophages derived from the THP-1 cell line, a more representative model of the human immune system in a state of differentiation, was also analyzed. In this approach, it was observed that the mean CC50 values ??were approximately nine times higher than those recorded in J774A.1 cells, indicating lower toxicity in a model of greater physiological relevance and reinforcing the selective profile of the compounds for the parasite. The data obtained indicate that the antileishmanial activity of nerolidol and HPS is strongly associated with their direct action on the parasite's plasma membrane. The initial increase in fluidity may favor ionic leakage and depolarization of the cell membrane, causing mitochondrial hyperpolarization and increased ROS production, which triggers a sequence of events, including membrane rigidification, resulting in irreversible structural damage and death of the parasite.Item Uso da Cannabis sativa no tratamento do mal de Parkinson(Universidade Federal de Goiás, 2025-06-09) Silva, Kamyla Martins e; Camargo, Leandra Borges de; Menegatti, Ricardo; Menegatti, Ricardo; Paula, José Realino de; Mendonça, Reginaldo TeixeiraParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by impaired motor control and a substantial decline in patients’ quality of life. Conventional treatments, such as levodopa, are effective in alleviating motor symptoms; however, their efficacy often diminishes over time and they are frequently associated with significant side effects. In this context, the therapeutic use of medical cannabis has emerged as a potential alternative. This study aims to review the current scientific literature regarding the effects of cannabinoids in the treatment of PD, with a focus on their therapeutic potential and possible neuropsychiatric implications. Clinical trials, systematic reviews, and recent peer-reviewed publications were analyzed. The findings suggest that cannabinoids—particularly cannabidiol (CBD)—exhibit neuroprotective, anxiolytic, and anti-inflammatory properties. These effects may contribute to the alleviation of symptoms such as tremors, muscle rigidity, sleep disturbances, and anxiety. Nevertheless, the available studies often suffer from methodological limitations, and there is a pressing need for more rigorous randomized controlled trials (RCTs) to determine the long-term efficacy and safety of cannabinoid-based therapies in PD. In conclusion, while medical cannabis shows therapeutic promise in the management of Parkinson’s disease, its use should be considered with caution, grounded in robust scientific evidence and guided by specialized medical supervision.Item Fast and new microbiological method for evaluating the potency of marbofloxacin based-tablets(Universidade Federal de Goiás, 2023-12-07) Ferreira, Raissa Gabrielle Lima; Torres, Ieda Maria Sapateiro; Kogawa, Ana Carolina; Kogawa, Ana Carolina; Silva, Luís Antônio Dantas; Gil, Eric de SouzaMarbofloxacin (MAR) is an antimicrobial belonging to the fluoroquinolone class and is marketed in the form of tablets. There is no microbiological monograph in official compendia to evaluate the potency of the final product. Furthermore, the literature is scarce in this context. Objective: The objective is to develop and validate a microbiological method by turbidimetry to evaluate the potency of MAR-based tablets, based on the principles of green analytical chemistry. Methods: Purified water–ethanol (9 þ 1, v/v) was used as diluent to prepare the MAR solutions at concentrations of 0.25, 0.8, and 2.56 mg/mL, brain heart infusion (BHI) broth as culture media, E. coli American Type Culture Collection (ATCC) 25922 at 10% and incubation in a shaker at 37C for 4 h were used in the method. Results: The method was: linear in the range of 0.25 to 2.56 mg/mL; selective against the sample adjuvants; precise (intra-day RSD 2.26%, inter-day RSD 3.49%, and inter-analyst RSD 3.59%); accurate with a recovery of 100.20%; and robust against changes in culture medium volume in the tube, shaker rotation, and incubation temperature in the shaker. The potency of MAR tablets was 96.98% using the proposed method. Conclusion: The turbidimetric method developed is a new, fast, and optimized option to the routine QC of MAR in tablets, since it allows the evaluation of the drug’s potency in the final product and can be used to complement the results of the physicochemical analysis, in addition to being a green and sustainable alternative.Item O uso da nanotecnologia na fotoestabilização da avobenzona(Universidade Federal de Goiás, 2024-01-22) Feres, Juliana Rezende Vilela; Diniz, Danielle Guimarães Almeida; Diniz, Danielle Guimarães Almeida; Pascoa, Henrique; Santos, Yanka Machado de PaulaThe ultraviolet light reaching the Earth's surface can cause irreparable damage to the skin, ranging from premature aging and sunburns to cancer. To prevent this from happening, formulations have been developed with the aim of blocking the penetration of radiation into the deeper layers of the skin, known as sunscreens. The active components present in these products are ultraviolet (UV) filters, which can either reflect and disperse UV rays, as is the case with inorganic filters, or absorb the rays and release energy in the form of heat or in the visible light spectrum. However, a portion of UV filters exhibits photoinstability issues, leading to a decrease in the formulation's effectiveness, evidenced by a reduction in the SPF value. The discovery of the photodegradation process has led to the incorporation of new technologies in formulation development, whether through the addition of antioxidant substances, such as omega-3 and resveratrol, or through the adoption of nanotechnology, using solid lipid nanoparticles (SLNs), liposomes, inorganic nanoparticles, and polymeric nanoparticles. One of the most widely used UV filters in sunscreens is avobenzone, which, despite its excellent potential for absorbing UV radiation, has an unstable chemical structure, requiring protective mechanisms in the formulation, thus becoming the subject of various studies. Therefore, the incorporation of nanotechnological techniques into formulations containing avobenzone is promising for the development of more effective sunscreens. The objective of this work was to compile information about the incorporation mechanisms of avobenzone in sunscreens in order to improve the stability of the molecule.Item Sistemas lipídicos para liberação de fármacos no sistema nervoso central: estratégias de delivery baseada na estrutura e composição dos lipídios cerebrais(Universidade Federal de Goiás, 2024-01-19) Fleury, Suzana Grzelak Borges Reis; Vieira, Thalyta Lopes; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Hayasaki , Tácio Gonçalves; Salomão, Mariana ArraesThe pharmacological treatment of neurological disorders has proven to be essential in controlling symptoms of central nervous system (CNS) diseases. Although effective, the low aqueous solubility of some lipophilic drugs that act on the CNS limits their absorption and bioavailability at the intended site. To overcome these limitations, different technological approaches have been explored for lipid-based drug delivery. These systems are designed to increase the solubility of the active compound, facilitate intestinal absorption, and avoid pre-systemic metabolism, thereby improving oral bioavailability. Advances in the development of these systems may also enable the exploration of new target-directed therapies by delivering drug molecules precisely where they are needed, which is crucial for CNS-related pathologies. This study focuses on exploring the lipid composition of the brain, with an emphasis on polyunsaturated fatty acids that show potential for interacting with nervous tissue to design lipid-based systems for brain drug delivery. Thus, the development of lipid-based drug delivery systems modeled after the brain's composition appears as a promising strategy to optimize pharmacokinetics, targeting, and efficacy in the treatment of CNS diseases.Item Avanços da nanotecnologia no desenvolvimento de dermocosméticos: um enfoque nas estratégias tecnológicas de produtos antienvelhecimento(Universidade Federal de Goiás, 2024-01-17) Silva, Millena Martins Oliveira; Silva, Luís Antônio Dantas; Oliveira, Nathalia Côrrea de Almeida; Salomão, Mariana Arraes; Silva, Luís Antônio DantasThe skin plays a crucial role in personal image and aesthetics and is susceptible to the manifestation of signs of aging. Therefore, the search for innovative solutions to prevent and mitigate this physiological phenomenon has increased. In this context, dermocosmetic products with anti-aging action stand out for being economical, easy to apply, and for the absence of associated injuries when compared to other interventions. However, the effectiveness of dermocosmetics is compromised by the complexity of skin penetration, attributed to skin stratification and the dimensions of dermocosmetic actives. Thus, nanotechnological strategies applied to dermocosmetics assume significant relevance, exerting a substantial impact on improving their efficacy. This study will provide a detailed and focused exposition of nanotechnological systems, highlighting their multifunctional properties and their application in the effective encapsulation of dermocosmetic actives with anti-aging action. The approach aims to demonstrate how nanotechnology can enhance the effectiveness of skin treatments by overcoming obstacles related to skin penetration, stability of dermocosmetics actives, and control of their release.Item Estudo da eficiência de Processos Oxidativos Avançados (POAs) para a degradação de contaminantes emergentes(Universidade Federal de Goiás, 2023-12-18) Silva, Ludmila Lorrane Martins; Teixeira, Guilhermina Ferreira; Teixeira, Guilhermina Ferreira; Colmati Junior, Flavio; Oliveira, Gisele Augusto Rodrigues deTo explore methods to contribute to the access of potable water for the population, this work employed Advanced Oxidative Processes (AOPs) for the recovery of aquatic effluents contaminated by contaminants of emerging concern (CECs). The chosen methods were photocatalysis, photolysis, and electrolysis, and the contaminants studied were the Brilliant Blue dye and the drugs Paracetamol and Ibuprofen. Photocatalysis was conducted using an aquarium purifier equipped with an 18 W UV lamp as a photoreactor, and sodium niobate compound as a photocatalyst. Regarding the degradation of the dye, the photocatalytic process showed an efficiency of over 90%, while for the degradation of the drug Paracetamol, the efficiency was approximately 54%. When photolysis was employed at pH=9 for the degradation of Paracetamol, the efficiency was around 75%. In terms of electrolysis, when working with a Paracetamol solution with a concentration of 10 mg.L-1 and NaCl 0.05 mol.L -1 as an electrolyte, it was observed that after 5 minutes of the experiment, the process efficiency was around 90%. However, when the Paracetamol concentration increased to 20 mg.L-1 , the same degradation efficiency occurred after 15 minutes of testing. Regarding Ibuprofen, due to its low solubility in water, the results obtained were inconclusive.Item Estratégias nanobiotecnológicas para tratamento da artrite reumatoide: uma revisão integrativa(Universidade Federal de Goiás, 2024-01-17) Freitas, Leticia Silva Oliveira; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Nascimento, Thais Leite; Hayasaki, Tacio GonçalvesRheumatoid arthritis (RA) is a systemic autoimmune pathology characterized by a chronic inflammatory process that affects the synovial tissue of the joints, significantly compromising the quality and life expectancy of patients. Conventional treatment, composed of nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids (GCs), conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), targeted synthetic DMARDs, and biological DMARDs, faces considerable challenges. These include the high cost associated with the development of biological agents, frequent administration and high doses, severe adverse events due to lack of specificity and non-selective immunosuppression, low efficacy in some patients, short half-life of drugs, and limited understanding of the mechanisms of action of DMARDs. In this scenario, nanotechnology emerges as a promising approach to address the limitations of conventional treatment. It offers new perspectives by providing specificity to the joints through active and passive targeting strategies, overcoming challenges such as increased dose, administration frequency, and associated adverse effects. Therefore, this review explores different approaches of nanoparticle delivery systems, including polymeric nanoparticles, lipid-based nanoparticles, and metallic nanoparticles, highlighting their strategies and outcomes in rheumatoid arthritis models.Item Nanobiotecnologia no desenvolvimento e inovação de biossensores para aplicação na área biomédica: uma revisão da literatura(Universidade Federal de Goiás, 2024-01-22) Marinho, Millena de Sousa; Vieira, Jessika Chiarelli; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Costa, Sérgio Henrique Nascente; Pereira, Jhon Kennedy AlvesNanobiotechnology is an interface area between nanotechnology and biotechnology that has shown constant growth in different areas. Among these areas of application is the biomedical area, notably diagnostic medicine, with the development of rapid and accurate diagnostic systems, known as biosensors. These devices present an advance in the diagnosis of diseases, as they are devices that can diagnose the disease from the earliest stages, presenting selectivity, specificity and sensitivity comparable to conventional methods. Furthermore, they have several advantages, particularly highlighting their agility in response time. The purpose of this work was to analyze and describe the use of biosensors in the biomedical area in light of the growing development of new diagnostic and screening tools through a narrative review of the literature. Eight research articles were selected that met the acceptance criteria and were subdivided into four topics, being the biosensor used for glucose monitoring, cancer detection, detection of infectious diseases and detection of hepatotoxicity. It was concluded that biosensor systems will be increasingly present in the routine of pharmacies and clinical analysis laboratories in light of the new RDC 786, of May 5, 2023.Item Uso de probióticos em dermocosméticos destinados ao tratamento de pele acneica(Universidade Federal de Goiás, 2024-01-18) Szikszay, Gabriela de Angelis; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Marreto, Ricardo Neves; Gonçalves, Priscila Bianca Rodrigues da RochaDespite being a very prevalent and common skin condition, acne is still a disease whose pathophysiological mechanisms are not very well defined and fully understood. Its conventional therapeutic line presents challenges in its effectiveness and efficiency, in addition to promoting many adverse effects, directly impacting the quality of life of affected individuals. Therefore, new alternatives have been investigated. One of the areas that has been explored to better understand the complexity of acne involves the microbiota and its dysbiosis process. Recent studies point to the importance of maintaining homeostasis of the skin's microbiota for better management of the clinical manifestations of the disease. Among the new therapeutic alternatives that act on the microbiota are topical probiotics. Evidence shows that these have inhibitory activity on acne mechanisms and present a clinical-therapeutic alternative in the management of acne by preventing the growth of pathogenic bacteria and the development of inflammatory processes. However, the therapeutic scenario of topical probiotics is still evolving, requiring greater exploration and clarification on the subject through the promotion of studies that demonstrate better clinical-therapeutic capacity.Item Dissolução intrínseca: uma importante metodologia na caracterização físico-química de fármacos(Universidade Federal de Goiás, 2024-01-18) Alves, Flávio Ricardo Bueno; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Flores, Caroline Luiza Martins; Pires, JaderIn the production process of a medicine, so that it can be made available for sale, several regulated steps are possible to be strictly followed, from research into the physicochemical properties of the medicine until its release. In the development cycle of a drug, tests and analytical trials are carried out, from the active pharmaceutical ingredient (IFA) to the finished product. Among the tests carried out with IFA there is an intrinsic dissolution, which is capable of providing results of interest for the quality control of raw materials, development of a new formulation, bioexemption studies and display of in-vitro in-vivo results. Therefore, despite not being a new methodology, it has great potential for application in research and the pharmaceutical industry.Item Prescrição farmacêutica de fitoterápicos: aspectos regulatórios(Universidade Federal de Goiás, 2024-11-27) Parreira, Ana Paula Gomes; Silva, Luana Inácia Ferreira; Dewulf, Nathalie de Lourdes Souza; Dewulf, Nathalie de Lourdes Souza; Santos, Pierre Alexandre dos; Cardoso, Thaissa CostaAccording to The Collegiate Board Resolution (RDC) N°26/2014 of the Brazilian Health Regulatory Agency (Anvisa), herbal medicines are industrialized products made exclusively from the active raw materials of plants, whose efficacy and safety are supported by clinical evidence, ensuring consistent product quality. In Brazil, phytotherapy was integrated into the Brazilian National Health System (SUS) in 2006 through the National Policy on Integrative and Complementary Practices (PNPIC). The development of phytotherapy has favored the regulation of pharmaceutical prescription by the Brazilian Federal Pharmacy Council (CFF) through the resolutions CFF 546/2011, 585/2013, and 586/2013. The study aimed to analyze the regulatory aspects related to the pharmaceutical prescription of herbal medicines. In order to analyze these aspects, an integrative review, a gray literature search and a document analysis were carried out. The databases used for the integrative review were Medline, Lilacs and SciELO, covering the period from January/2008 to December/2023. The gray literature search was undertaken on Google Academic with different combinations of keywords, but only “prescription”, “pharmaceutical” and “herbal medicines” provided pertinent results. The document analysis was conducted on websites of institutions relevant to the pharmaceutical practice: Brazilian National Association of Magistral Pharmacists (Anfarmag), Anvisa, Brazilian Ministry of Health (MS), CFF, Goiás State Health Department, Goiânia City Council, General Secretariat of Government (SGG), Superintendence of Health Surveillance (Suvisa) and Goiânia Health Surveillance Department. The integrative review identified 55 studies, but after reading the title and abstract, none of the results answered the research question. The gray literature search resulted in 13 articles, but only two focused on the regulatory aspects. Sixteen regulations were identified, including one federal law, one state law, one Brazilian Ministry of Health ordinance, five CFF resolutions, five Anvisa RDCs, and three normative instructions. No specific regulations were found in other institutions analyzed, such as SGG, Suvisa, and the Health Surveillance Department of Goiânia. Although the pharmaceutical prescription of herbal medicines requires specific training, the regulation allows the pharmacist to dispense these medicines, highlighting a normative discrepancy that raises concerns about safety and effectivity, as dispensing also affects the patient.Item Indicadores de qualidade para farmácia clínica no ambiente hospitalar: uma revisão de literatura(Universidade Federal de Goiás, 2024-12-04) Barbosa, Dirce Natalia Oliveira; Lima, Isadora Soares; Provin, Mércia Pandolfo; Provin, Mércia Pandolfo; Soares, Amanda Queiroz; Carvalho, Nubia Cristina Burgo Godoi deIntroduction: In Brazil, Resolution 585/2013 and Law 13.021/2014 established clinical pharmacy services as essential in the healthcare environment. In this context, it is crucial to adopt mechanisms such as quality indicators, which assess the pharmacist's performance and the overall environment, promoting improvements. This study analyzed the literature published since the implementation of this legislation, focusing on quality indicators applied to clinical pharmacy services in different institutions and regional and economic contexts. Methodology: A total of 28 studies related to the topic were collected, of which 8 met the inclusion criteria for specifically addressing quality indicators in clinical pharmacy services. The analysis categorized the identified indicators into the topics “structure”, “process” and “outcomes”. Results and discussion: From the selected studies, approximately 140 total indicators were identified, amounting to around 60 general indicators distributed across the mentioned topics. Developed countries already have standardized packages of indicators to evaluate healthcare institutions, highlighting their importance in improving quality. However, in Brazil, challenges such as the lack of standardization, practical implementation difficulties, and limited scientific production on the subject hinder their adoption. Conclusion: Although quality indicators are widely used in other countries to monitor healthcare services, Brazil faces significant barriers to incorporating them into clinical pharmacy services. The lack of standardization and the scarcity of specific studies emphasize the need for academic and institutional efforts. Adopting these indicators is essential to establish clinical pharmacy as a strategic service within the Brazilian healthcare system.Item Estudo e compreensão da disbiose cutânea induzida pelo uso de antimicrobianos: implicações na homeostase da pele e a relação com a dermatite atópica(Universidade Federal de Goiás, 2024-12-04) Santos, Anna Karolina do Nascimento; Ribeiro, Rayssa Farias; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Rodrigues, Laís de Brito; Chaul, Luíza ToubasThe human skin harbors a diverse microbiota that plays an essential role in maintaining skin integrity. Excessive or prolonged use of antimicrobials, such as antibiotics, can destabilize this microbiota, resulting in an imbalance known as dysbiosis. This condition compromises the skin barrier and exacerbates inflammatory responses, contributing to the onset and worsening of AD. Current therapeutic approaches for AD prioritize symptom management but often fail to address the preservation or restoration of the microbiota. Promising strategies, such as the use of topical probiotics and postbiotics, have shown potential in promoting microbial balance and improving skin health. This study investigates the relationship between the use of antimicrobials and skin dysbiosis, as well as its implications for the development and worsening of atopic dermatitis (AD). A literature review was conducted in scientific databases such as PubMed, Scopus, and SciELO, using descriptors and inclusion criteria.Item Diabetes mellitus: classificação, complicações e desenvolvimento de terapias personalizadas por impressão 3D(Universidade Federal de Goiás, 2024-12-06) Rosa, Lorenna Gomes da Silva; Nascimento, Lis Raquel Silva do; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Costa, Sérgio Henrique Nascente; Pascoa, HenriqueDiabetes Mellitus (DM) is a chronic condition of increasing relevance to public health, with a significant economic and social impact, especially due to the rise in prevalence and associated complications, such as cardiovascular diseases and kidney failure. The incidence of DM has been increasing globally, with type 2 being the most prevalent, directly linked to factors such as obesity and physical inactivity. Traditional treatment involves glucose monitoring and the use of (bio)pharmaceuticals, such as insulin, but a personalized approach shows promise. 3D printing, with its applications in medical devices such as insulin-controlled release systems and pancreatic cell bioprinting, emerges as a significant innovation. This technology allows the creation of solutions tailored to individual patient needs, with the potential to improve glycemic control, reduce complications, and offer new therapeutic perspectives, including the regeneration of pancreatic tissue. However, the use of 3D printing still faces technical challenges, such as manufacturing precision and material biocompatibility, as well as regulatory and cost issues. The pharmacist plays an essential role in integrating these technologies into DM treatment, contributing to patient education and therapy personalization. The development of these innovative approaches points to a future with more effective and accessible treatments for diabetic patients, promoting better clinical outcomes and quality of life.Item Potencial cicatrizante dos géis de espécies de Aloe L. no tratamento de feridas(Universidade Federal de Goiás, 2024-11-29) Nascimento, Isabela Guimarães Araújo do; Bragato, Renata Borges; Santos, Pierre Alexandre dos; Santos, Pierre Alexandre dos; Pacheco, Fernanda Marques; Cabral, Raphael OliveiraWounds are injuries on the skin whose healing is a physiological process that restores the integrity of the damaged tissue. During this repair, however, complications may arise, increasing the demand for new drugs that accelerate healing and the medicinal plants, which represent a big part of the treatments around the world, have great healing potential. Among them, the genus Aloe L. is one of the most widespread and A. vera has already been widely used as a topical therapeutic agent. Therefore, the main objective of the present study was to carry out a survey about the use of gels from other Aloe species applied to wound healing. As a result, 17 articles were obtained and eight different Aloe species (A. arborescens, A. eru, A. ferox, A. littoralis, A. marlothii, A. muth-muth, A. saponaria and A. trigonantha) were discussed in the selected studies and their healing properties were analyzed. However, although research displayed the healing potential of these species in wounds, there is still a need for more studies on this topic, including other genus species.Item Uso de fentanil em sistemas de liberação transdérmica: uma revisão descritiva sobre seus aspectos biofarmacêuticos, de segurança e eficácia(Universidade Federal de Goiás, 2024-12-09) Barros, Isadora Medeiros; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Batista, Karla de Aleluia; Paula, Hellen da Silva Cintra deResumo em outro idioma: Introduction: Pain control, whether acute or chronic, requires specific approaches due to its different characteristics and intensities. Pain can limit daily activities and generate dependence on external care, especially when treatment requires frequent intravenous medication, or when it interrupts the patient's routine and increases the risk of hospitalization and drug resistance. The use of transdermal delivery system, such as the fentanyl patch, emerges as an alternative to overcome these challenges, allowing continuous dosing, less need for clinic visits and greater independence. This method contributes to a more comfortable and safe pain management. Objective: This study aimed to conduct a descriptive review on the use of fentanyl in transdermal patches, addressing pharmacological aspects, therapeutic advantages and challenges in pain management. Based on scientific publications from academic databases, we sought to analyze the efficacy and safety of this controlled release system. Method: The search was conducted in the PubMed, Web of Science and Google Scholar databases, covering the period from 1992 to 2024. The descriptors “Fentanyl” and “'transdermal patch'” were used. The selected articles were fully analysed to collect relevant data. Results: Thirty-one articles on the use of the transdermal fentanyl patch were analyzed, with frequent comparisons with the standard morphine treatment. The transdermal fentanyl patch (TFP) presents itself as an effective and safe alternative in the management of chronic and acute pain, standing out mainly in the treatment of oncology patients and in the postoperative period. The analyzed studies confirm the efficacy of the TFP, reducing pain intensity and dependence on additional analgesics, while presenting a favorable adverse effect profile compared to other therapies, such as oral morphine. The results indicated that fentanyl offers better analgesic performance and comfort in pain management, especially in patients with chronic pain, such as non-cancer patients, and in postoperative situations. Its application offers advantages over other forms of opioid administration, providing more effective pain control and better quality of life, with less need for periodic interventions. The fentanyl patch proved to be effective in controlling chronic and acute pain, with advantages over other pharmaceutical forms, such as greater convenience and less need for interventions. When used correctly, it provides effective pain control, with fewer complications associated with other routes of administration. However, the occurrence of side effects, such as nausea, mortality, and constipation, highlights the importance of adequate monitoring, especially at higher doses. Conclusion: Thus, the present study showed that the transdermal fentanyl patch represents a promising therapeutic option, as long as it is administered with individual care and adjustments, reinforcing its relevance in multimodal analgesia protocolsItem Cyto-Safe: uma ferramenta de aprendizado de máquina para identificação precoce de compostos citotóxicos na descoberta de fármacos(Universidade Federal de Goiás, 2024-11-29) Oliveira, Francisco Lucas Feitosa de; Andrade, Carolina Horta; Andrade, Carolina Horta; Silva, Artur Christian Garcia da; Silva, Meryck Felipe Brito daIntroduction: Cytotoxicity is the ability of a substance to cause irreversible damage to living cells, leading to cell death. Evaluating cytotoxicity is crucial in the early stages of drug development, allowing for the early identification of toxic compounds, mitigating risks, and reducing animal testing. Quantitative Structure-Activity Relationship (QSAR) models that use Artificial Intelligence (AI) algorithms can predict cytotoxicity based on the chemical structure of compounds. Objective: To develop and validate QSAR models to predict the cytotoxicity of drug candidates and make them available as a free web application. Methods: A dataset from the literature with approximately 90,000 compounds tested on mouse embryonic fibroblasts (3T3) and human embryonic kidney cells (HEK 293) was used. After data cleaning and curation, Extended-Connectivity Fingerprints descriptors were generated. The models were created using the Light Gradient Boosting algorithm with 80% of the data for training and 20% for validation. Results: The generated models showed good performance, with a balanced accuracy (BACC) of 0.91 after applying data balancing techniques. The best models are available in the web application Cyto-Safe (http://cytosafe.labmol.com.br/), which incorporates elements of explainable AI, allowing visualization of molecular regions associated with cytotoxicity. Conclusion: The models were effective in classifying compounds regarding cytotoxicity in the 3T3 and HEK 293 cell lines. Cyto-Safe is a technological product that offers the scientific community a fast and reliable tool to evaluate the cytotoxicity of chemical compounds without experimental data, accelerating drug discovery.Item Elaboração de dispositivo de registro para auxílio na administração correta de medicamentos(Universidade Federal de Goiás, 2024-12-13) Guimarães, Gabriel Sousa Brito; Ferreira, Teófilo Roberto dos Santos; Provin, Mércia Pandolfo; Provin, Mércia Pandolfo; Oliveira, Ana Cristina Santos Rocha; Moreira, Pryscila RodriguesThe administration of medications is a central activity in clinical practice, indispensable for the management and control of numerous diseases. However, errors related to medication use represent a challenge for public health, with impacts on patient safety. Forgetfulness and dose duplication in medication administration are common issues that affect treatment adherence and therapeutic efficacy. These errors can occur in both home settings and healthcare institutions and are influenced by various factors. To mitigate this problem, this work aims to describe the development process of a device to assist patients and caregivers in recording medication usage. The project construction was divided into three stages: ideation, prototyping, and anonymous evaluation by healthcare professionals. The ideation stage involved reviewing existing models in the literature, whether already commercialized or not. During prototyping, the goal was to create an organizational device addressing the disadvantages of existing models. In the final stage, a professional evaluation was conducted by a multidisciplinary healthcare team anonymously, focusing on the potential success of the project in achieving itspurpose. The prototype includes two overlapping 3mm MDF boards, displaying the days of theweek, and received positive feedback from the multidisciplinary healthcare team. This researchaimed to highlight the relevance of supporting proper medication administration, generating positive expectations regarding its future applicability for the population.