Plataformas de microagulhas para liberação transdérmica de fármacos: uma revisão de literatura
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Data
2023-02-10
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Universidade Federal de Goiás
Resumo
The skin is an attractive option for the delivery of therapeutic agents such as vaccines, biomolecules, and small molecules. However, the superficial layer of the skin, the stratum corneum, can limit the bioavailability of the pharmaceutical active. Drug penetration through the skin is limited to potent molecules with low molecular weight and moderate fat solubility. The efficacy of a drug depends not only on the properties of the active component, but also on the underlying mechanism of delivery to the body. From this perspective, it is important to consider the optimal method of drug delivery according to the drug's properties. The use of micro-needling enables minimally invasive and highly safe delivery. Microneedling, a transdermal drug delivery system, is growing rapidly due to its advantages in improving patient access to drugs, replacing other routes of administration. The purpose of this literature review was to present microdevices as a means of drug administration through microneedles, as well as the technical characteristics and limitations.
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Palavras-chave
Microagulhas, Dispositivos de liberação, Administração transdérmica, Tecnologias terapêuticas, Microneedles, Administration devices, Transdermal administration, Therapeutic technologies
Citação
LIMA, Giovanna Almeida; COSTA, Hemerson da Silva. Plataformas de microagulhas para liberação transdérmica de fármacos: uma revisão da literatura. 2023. 24 f. Trabalho de Conclusão de Curso (Bacharelado em Farmácia) – Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2023.