Sistemas lipídicos como abordagens tecnológicas para melhora das propriedades biofarmacêuticas de fármacos: levantamento das estratégias e mecanismos descritos na literatura
Nenhuma Miniatura disponível
Data
2023-08-08
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
In the current situation, technological approaches have been sought to optimize the delivery of drugs and guarantee their therapeutic efficacy. The use of lipid systems to improve the bioavailability of orally administered drugs can help correct problems related to the physicochemical properties of the drug, such as low solubility and/or low permeability. The aim of this article was to address lipid systems as technological strategies for improving the biopharmaceutical properties of orally administered drugs. The methodology used was a survey of studies described in the literature over the last 20 years, describing the subject, and especially the benefits and challenges of using lipid systems for orally administered drugs. The theoretical framework therefore presented the parameters for the use of lipid systems as drug carriers, considering their challenges and classifications, highlighting strategies to overcome absorption problems through the use of lipid systems and the main mechanisms, as well as current applications. The technological development of lipid-based drug delivery systems therefore appears to be a promising strategy for improving the biopharmaceutical properties of drugs. With an in-depth understanding of the physicochemical characteristics of drugs, formulation techniques and the gastrointestinal system, it is possible to overcome the challenges of the applicability of lipid formulations and highlight their benefits, which will contribute to significant advances in the field of pharmaceutical technology.
Descrição
Palavras-chave
Formulações de bases lipídicas, Propriedades biofarmacêuticas de fármacos, Tecnologias biofarmacêuticas, Sistemas lipídicos, Administração por via oral, Lipid-based formulations, Biopharmaceutical properties of drugs, Biopharmaceutical technologies, Lipid systems
Citação
CARVALHO, Gabriel Cruvinel; GOMES, Lara Ferreira. Sistemas lipídicos como abordagens tecnológicas para melhora das propriedades biofarmacêuticas de fármacos: levantamento das estratégias e mecanismos descritos na literatura. 2023. 22 f. Trabalho de Conclusão de Curso (Graduação) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Goiás, 2023.