Recovery trend to co-exposure of iron oxide nanoparticles (γ-Fe2O3) and glyphosate in liver tissue of the fish Poecilia reticulata
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2021
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Citrate-coated iron oxide nanoparticles (IONPs) have potential use in environmental remediation, with possibilities in decontaminating aquatic environments exposed to toxic substances. This study analyzed IONPs associated to Roundup Original, a glyphosate-based herbicide (GBH), and pure glyphosate (GLY), through ultrastructural and histopathological biomarkers in liver tissue, from females of Poecilia reticulata exposed to: iron ions (0.3 mg/L) (IFe) and IONPs (0.3 mgFe/L) associated with GLY (0.65 mg/L) and GBH (0.65 mgGLY/L (IONP + GBH1) and 1.30 mgGLY/L (IONP + GBH2)) for a period of 7, 14 and 21 days, followed by an equal post-exposure period only in reconstituted water. For the assays, the synthetized IONPs had crystalline and rounded shape with an average diameter of 2,90 nm, hydrodynamic diameter 66,6 mV, zeta potential −55,4 and diffraction profile of maghemite (γ-Fe2O3). The data obtained by biomarkers indicated a high inflammatory response in all treatments. These same parameters, considered during the post-exposure period indicated recovery in reaction patterns of circulatory disturbances and regressive changes, resulting in average reductions of 37,53 points in IFe, 21 points in IONP + GBH1, 15 points in IONP + GBH2 and 11 points in IONP + GLY in total histopathological index of liver after 21 days post-exposure. However, although the cellular and tissue responses were significant, there was no change in the condition factor and hepatosomatic index, denoting resilience of the experimental model.
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Iron ions, Glyphosate, Roundup, Liver, Recovery, Fish
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FARIA, João Marcos de Lima et al. Recovery trend to co-exposure of iron oxide nanoparticles (γ-Fe2O3) and glyphosate in liver tissue of the fish Poecilia reticulata. Chemosphere, Amsterdam, v. 282, e130993, 2021. DOI: 10.1016/j.chemosphere.2021.130993. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S004565352101465X?via%3Dihub. Acesso em: 27 set. 2023.