Versatile fabrication of paper-based microfluidic devices with high chemical resistance using scholar glue and magnetic masks

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dc.creatorCardoso, Thiago Miguel Garcia
dc.creatorSouza, Fabricio Ribeiro de
dc.creatorGarcia, Paulo de Tarso
dc.creatorRabelo, Denilson
dc.creatorHenry, Charles S.
dc.creatorColtro, Wendell Karlos Tomazelli
dc.date.accessioned2024-11-06T15:59:00Z
dc.date.available2024-11-06T15:59:00Z
dc.date.issued2017-06
dc.description.abstractSimple methods have been developed for fabricating microfluidic paper-based analytical devices (μPADs) but few of these devices can be used with organic solvents and/or aqueous solutions containing surfactants. This study describes a simple fabrication strategy for μPADs that uses readily available scholar glue to create the hydrophobic flow barriers that are resistant to surfactants and organic solvents. Microfluidic structures were defined by magnetic masks designed with either neodymium magnets or magnetic sheets to define the patter, and structures were created by spraying an aqueous solution of glue on the paper surface. The glue-coated paper was then exposed to UV/Vis light for cross-linking to maximize chemical resistance. Examples of microzone arrays and microfluidic devices are demonstrated. μPADs fabricated with scholar glue retained their barriers when used with surfactants, organic solvents, and strong/weak acids and bases unlike common wax-printed barriers. Paper microzones and microfluidic devices were successfully used for colorimetric assays of clinically relevant analytes commonly detected in urinalysis to demonstrate the low background of the barrier material and generally applicability to sensing. The proposed fabrication method is attractive for both its ability to be used with diverse chemistries and the low cost and simplicity of the materials and process.
dc.identifier.citationCARDOSO, Thiago Miguel Garcia et al. Versatile fabrication of paper-based microfluidic devices with high chemical resistance using scholar glue and magnetic masks. Analytica Chimica Acta, [s. l.], v. 974, p. 63-68, 2017. DOI: 10.1016/j.aca.2017.03.043. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0003267017303975?via%3Dihub. Acesso em: 8 ago. 2024.
dc.identifier.doi10.1016/j.aca.2017.03.043
dc.identifier.issn0003-2670
dc.identifier.issne- 1873-4324
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0003267017303975?via%3Dihub
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Restrito
dc.subjectClinical trial assays
dc.subjectColorimetric detection
dc.subjectHydrophobic flow barriers
dc.subjectPaper microfluidics
dc.subjectPoly(vinyl) acetate
dc.subjectUrinalysis
dc.titleVersatile fabrication of paper-based microfluidic devices with high chemical resistance using scholar glue and magnetic masks
dc.typeArtigo

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