Long-term clearance and biodistribution of magnetic nanoparticles assessed by AC biosusceptometry
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2022
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Resumo
Once administered in an organism, the physiological parameters of magnetic nanoparticles
(MNPs) must be addressed, as well as their possible interactions and retention and elimination
profiles. Alternating current biosusceptometry (ACB) is a biomagnetic detection system used to
detect and quantify MNPs. The aims of this study were to evaluate the biodistribution and clearance
of MNPs profiles through long-time in vivo analysis and determine the elimination time carried out
by the association between the ACB system and MnFe2O4 nanoparticles. The liver, lung, spleen,
kidneys, and heart and a blood sample were collected for biodistribution analysis and, for elimination
analysis, and over 60 days. During the period analyzed, the animal’s feces were also collectedd. It was
possible to notice a higher uptake by the liver and the spleen due to their characteristics of retention
and uptake. In 60 days, we observed an absence of MNPs in the spleen and a significant decay in
the liver. We also determined the MNPs’ half-life through the liver and the spleen elimination. The
data indicated a concentration decay profile over the 60 days, which suggests that, in addition to
elimination via feces, there is an endogenous mechanism of metabolization or possible agglomeration
of MNPs, resulting in loss of ACB signal intensity.
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Magnetic nanoparticles, Alternate current biosusceptometry, Clearance, Biodistribution, Long-time analysis
Citação
SOARES, Guilherme A. et al. Long-term clearance and biodistribution of magnetic nanoparticles assessed by AC biosusceptometry. Materials, Basel, v. 15, n. 6, p. 1-14, 2022. DOI: 10.3390/ma15062121. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948936/. Acesso em: 11 abr. 2023.