3D printed microfluidic mixer for real-time monitoring of organic reactions by direct infusion mass spectrometry

Página do item simplificado
dc.creatorDuarte, Lucas da Costa
dc.creatorSilva, Igor Pereira da
dc.creatorMaciel, Lanaia Ítala Louzeiro
dc.creatorVaz, Boniek Gontijo
dc.creatorColtro, Wendell Karlos Tomazelli
dc.date.accessioned2023-07-11T15:49:18Z
dc.date.available2023-07-11T15:49:18Z
dc.date.issued2022
dc.description.abstract3D printing is a technology that has revolutionized traditional rapid prototyping methods due to its ability to build microscale structures with customized geometries in a simple, fast, and low-cost way. In this sense, this article describes the development of a microfluidic mixing device to monitor chemical reactions by mass spectrometry (MS). Microfluidic mixers were designed containing 3D serpentine and Y-shaped microchannels, both with a pointed end for facilitating the spray formation. The devices were fabricated entirely by 3D printing with fusion deposition modeling (FDM) technology. As proof-of-concept, micromixers were evaluated through monitoring the Katritzky reaction by injecting simultaneously 2,4,6-triphenylpropyllium (TPP) and amino acid (glycine or alanine) solutions, each through a different reactor inlet. Reaction product was monitored online by MS at different flow rates. Mass spectra showed that the relative abundances of the products obtained with the device containing the 3D serpentine channel were three times greater than those obtained with the Y-channel device due to the turbulence generated by the barriers created inside microchannels. In addition, when compared to the conventional electrospray ionization mass spectrometry (ESI-MS) technique, the 3D serpentine mixer offered better performance measured in relation to the relative abundance values for the reaction products. These results as well as the instrumental simplicity indicate that 3D printed microfluidic mixer is a promising tool for monitoring organic reactions via MS.pt_BR
dc.identifier.citationDUARTE, Lucas C. et al. 3D printed microfluidic mixer for real-time monitoring of organic reactions by direct infusion mass spectrometry. Analytica Chimica Acta, Amsterdam, v. 1190, e339252, 2022. DOI: 10.1016/j.aca.2021.339252. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0003267021010783?via%3Dihub. Acesso em: 28 jun. 2023.pt_BR
dc.identifier.doi10.1016/j.aca.2021.339252
dc.identifier.issn0003-2670
dc.identifier.issne- 1873-4324
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0003267021010783?via%3Dihub
dc.language.isoengpt_BR
dc.publisher.countryHolandapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.title3D printed microfluidic mixer for real-time monitoring of organic reactions by direct infusion mass spectrometrypt_BR
dc.typeArtigopt_BR

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IQ - Artigos publicados em periódicos