Avaliação das atividades angiogênica, antiangiogênica, genotóxica e antigenotóxica da spirulina
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2022
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Resumo
Objective: to evaluate the angiogenic, antiangiogenic, genotoxic and antigenotoxic
potential of Spirulina. Material and Methods: To evaluate angiogenesis and
antiangiogenesis, embryonated chicken eggs were used. For the genotoxicity tests, the micronucleus test was performed in mice treated intraperitoneally, with doses of 1000 mg
kg-1, 500 mg kg-1 and 250 mg kg-1 of the aqueous solution of Spirulina, within 24 hours,
concomitant with doxyrubicin. Results: the Spirulina solution in the three doses used,
caused a significant decrease in the percentage area of the vascular network in the
chorioallantoic membrane, when compared to the positive control, demonstrating
antiangiogenic activity. The Spirulina solution also showed genotoxic activity at the three
concentrations. When tested for antigenotoxic potential, the study showed a significant
decrease in micronucleus frequency in 4000 EPC, thus showing an antigenotoxic activity.
Conclusion: the Spirulina solution has antiangiogenic potential at the concentrations
tested, showing genotoxic and antigenotoxic activity.
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Angiogênese, Angiogenesis, Membrana corioalantóide, Micronúcleo, Spirulina, Chorioallantoic membrane, Micronucleus, Spirulina
Citação
CIRIACO, Roney Castro Ciriaco; SILVA, Tainan Ramos da; PONTES, Susy Ricardo Lemes; MADUREIRA, Luciane ; GONCALVES, Pablo; MRUE, Fátima; REIS, Paulo Roberto Melo. Avaliação das atividades angiogênica, antiangiogênica, genotóxica e antigenotóxica da spirulina. Vita et Sanitas, Trindade, v. 16, n. 1, p. 1-14, 2022. Disponível em: http://fug.edu.br/revistas/index.php/VitaetSanitas/article/view/262. Acesso em: 4 maio 2023.