Effects of terpenes on fluidity and lipid extraction in phospholipid membranes

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dc.creatorMendanha Neto, Sebastião Antônio
dc.creatorAlonso, Antonio
dc.date.accessioned2024-07-15T11:46:50Z
dc.date.available2024-07-15T11:46:50Z
dc.date.issued2015
dc.description.abstractElectron paramagnetic resonance (EPR) spectroscopy was used in a detailed study of the interactions of several terpenes with DPPC membranes. EPR spectra of a spin-label lipid allowed the identification of two well-resolved spectral components at temperatures below and above the main phase transition of the lipid bilayer. Terpenes caused only slight mobility increases in each of these spectral components; however, they substantially increased the population of the more mobile component. In addition, the terpenes reduced the temperature of the main phase transition by more than 8 °C and caused the extraction of the spin-labeled lipid. Nerolidol, which had the highest octanol–water partition coefficient, generated the highest amount of spin label extraction. Acting as spacers, terpenes should cause major reorganization in cell membranes, leading to an increase in the overall molecular dynamics of the membrane. At higher concentrations, terpenes may cause lipid extraction and thus leakage of the cytoplasmic content.
dc.identifier.citationMENDANHA, Sebastião Antonio; ALONSO, Antonio. Effects of terpenes on fluidity and lipid extraction in phospholipid membranes. Biophysical Chemistry, Amsterdam, v. 198, p. 45-54, 2015. DOI: 10.1016/j.bpc.2015.02.001. Disponível em: https://www.sciencedirect.com/science/article/pii/S0301462215000095?via%3Dihub. Acesso em: 26 maio 2023.
dc.identifier.doi10.1016/j.bpc.2015.02.001
dc.identifier.issn0301-4622
dc.identifier.issne- 1873-4200
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0301462215000095?via%3Dihub
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Física - IF (RMG)
dc.rightsAcesso Restrito
dc.subjectElectron paramagnetic resonance
dc.subjectTerpenes
dc.subjectMembrane fluidity
dc.subjectLipid extraction
dc.titleEffects of terpenes on fluidity and lipid extraction in phospholipid membranes
dc.typeArtigo

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