Emerging Plasmodium vivax resistance to chloroquine in South America: an overview

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dc.creatorGonçalves, Lígia Antunes
dc.creatorCravo, Pedro Vitor Lemos
dc.creatorFerreira, Marcelo Urbano
dc.date.accessioned2020-02-11T10:49:37Z
dc.date.available2020-02-11T10:49:37Z
dc.date.issued2014
dc.description.abstractThe global emergence of Plasmodium vivax strains resistant to chloroquine (CQ) since the late 1980s is complicating the current international efforts for malaria control and elimination. Furthermore, CQ-resistant vivax malaria has already reached an alarming prevalence in Indonesia, East Timor and Papua New Guinea. More recently, in vivo studies have documented CQ-resistant P. vivax infections in Guyana, Peru and Brazil. Here, we summarise the available data on CQ resistance across P. vivax-endemic areas of Latin America by combining published in vivo and in vitro studies. We also review the current knowledge regarding the molecular mechanisms of CQ resistance in P. vivax and the prospects for developing and standardising reliable molecular markers of drug resistance. Finally, we discuss how the Worldwide Antimalarial Resistance Network, an international collaborative effort involving malaria experts from all continents, might contribute to the current regional efforts to map CQ-resistant vivax malaria in South America.pt_BR
dc.identifier.citationGONÇALVES, Lígia Antunes; CRAVO, Pedro; FERREIRA, Marcelo Urbano. Emerging Plasmodium vivax resistance to chloroquine in South America: an overview. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 5, p. 1-6, 2014.pt_BR
dc.identifier.doi10.1590/0074-0276130579.
dc.identifier.issn 0074-0276
dc.identifier.issne- 1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18634
dc.language.isoporpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPlasmodium vivaxpt_BR
dc.subjectLatin Americapt_BR
dc.subjectChloroquinept_BR
dc.subjectResistancept_BR
dc.titleEmerging Plasmodium vivax resistance to chloroquine in South America: an overviewpt_BR
dc.typeArtigopt_BR

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