Alterações teciduais agudas induzidas em ratos wistar por trypanosoma cruzi
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Data
2007-06
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Editor
Marize Campos Valadares
Resumo
The Chagas disease, described in 1909, has a behavior that partially depends on the Trypanosoma
cruzi isolate. In this work, the parasitemy curve and the alterations in the tissues of the encephalus, heart, tongue,
esophagus, lungs, stomach, small and large intestines, kidneys and bladder of Wistar rats infected with
Trypanosoma cruzi isolated from a patient carrying the cardiac and digestive form of the disease, were analyzed.
Forty rats (ten groups of four animals each) were utilized. Two groups that were inoculated at 15 days and the
other two at 60 days with 10 x 103 or 10 x 104 trypomastigotes/animal, were submitted to an evaluation of
parasitemy at alternate days starting from the third day after inoculation. The organs listed were processed using
the routine histological technique, and then microscope slides were confectioned and stained with hematoxillin and
eosin. The animals inoculated at 60 days presented peaks of parasitemy ranging from 24,710 forms/mL of blood in
inoculates of 10 x 103 forms/animal to 28,240 forms/mL in inoculates of 10 x 104 forms/animal. The animals
inoculated at 15 days with 10 x 103 forms, presented a peak of 116,490 forms/mL, while the ones inoculated at 15
days with 10 x 104 forms had a peak of 229,450 forms/mL. The parasitemy peak occurred between the 21st and
23rd day after inoculation in the groups evaluated, whereas the animals inoculated at 15 days of age presented, for
both inoculates, higher values of parasitemy than the animals inoculated at 60 days. The histological analysis
demonstrated tropism in the heart, with tissue alterations such as: focal and diffuse inflammatory process,
perivascular infiltrate and parasite nests both intact and breached. Such processes presented cells such as
macrophages, lymphocytes, polymorph nuclear cells, plasmocytes and fibroblasts. The remaining organs
evaluated presented histological aspects similar to those of the control animals. There were greater alterations in
the cardiac tissue of the younger animals (15 days), submitted to the greater inoculum.
Descrição
Palavras-chave
Trypanosoma cruzi, Doença de Chagas, Infecção aguda, Rato, Chagas disease, Acute infection, Rat
Citação
OLIVEIRA, Kleber Mirallia de; SOUZA JÚNIOR, Nozelmar Borges de; MATA, Fabiana Ribeiro da; SABÓIA-MORAIS, Simone Maria Teixeira; AVERSI-FERREIRA, Tales Alexandre; MATA, João Roberto da. Alterações teciduais agudas induzidas em ratos wistar por trypanosoma cruzi. Revista Eletrônica de Farmácia, Goiânia, v. 7, n. 1, p. 86-94, jan./jun. 2007. Disponível em: <https://revistas.ufg.br/REF/article/view/2125/2072>.