Distinct amino acid and lipid perturbations characterize acute versus chronic malaria
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2019
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Chronic malaria is a major public health problem and significant challenge for disease eradication
efforts. Despite its importance, the biological factors underpinning chronic malaria are not
fully understood. Recent studies have shown that host metabolic state can influence malaria
pathogenesis and transmission, but its role in chronicity is not known. Here, with the goal of
identifying distinct modifications in the metabolite profiles of acute versus chronic malaria,
metabolomics was performed on plasma from Plasmodium-infected humans and nonhuman
primates with a range of parasitemias and clinical signs. In rhesus macaques infected with
Plasmodium coatneyi, significant alterations in amines, carnitines, and lipids were detected
during a high parasitemic acute phase and many of these reverted to baseline levels once a low
parasitemic chronic phase was established. Plasmodium gene expression, studied in parallel in
the macaques, revealed transcriptional changes in amine, fatty acid, lipid and energy metabolism
genes, as well as variant antigen genes. Furthermore, a common set of amines, carnitines, and
lipids distinguished acute from chronic malaria in plasma from human Plasmodium falciparum
cases. In summary, distinct host-parasite metabolic environments have been uncovered that
characterize acute versus chronic malaria, providing insights into the underlying host-parasite
biology of malaria disease progression.
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CORDY, Regina Joice et al. MaHPIC consortium ; et.al . distinct amino acid and lipid perturbations characterize acute versus chronic malaria. JCI insight, Ann Arbor, v. 4, n. 9, e125156, 2019. DOI: 10.1172/jci.insight.125156. Disponível em: https://insight.jci.org/articles/view/125156. Acesso em: 29 jan. 2025.