Distinct amino acid and lipid perturbations characterize acute versus chronic malaria

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dc.creatorCordy, Regina Joice
dc.creatorPatrapuvich, Rapatbhorn
dc.creatorCabrera Mora, Monica
dc.creatorJung-Ting, Chien
dc.creatorTharp, Gregory K.
dc.creatorKhadka, Manoj
dc.creatorMeyer, Esmeralda
dc.creatorLapp, Stacey A.
dc.creatorGardinassi, Luiz Gustavo Araujo
dc.creatorLili, Loukia N.
dc.date.accessioned2025-02-04T15:30:12Z
dc.date.available2025-02-04T15:30:12Z
dc.date.issued2019
dc.description.abstractChronic malaria is a major public health problem and significant challenge for disease eradication efforts. Despite its importance, the biological factors underpinning chronic malaria are not fully understood. Recent studies have shown that host metabolic state can influence malaria pathogenesis and transmission, but its role in chronicity is not known. Here, with the goal of identifying distinct modifications in the metabolite profiles of acute versus chronic malaria, metabolomics was performed on plasma from Plasmodium-infected humans and nonhuman primates with a range of parasitemias and clinical signs. In rhesus macaques infected with Plasmodium coatneyi, significant alterations in amines, carnitines, and lipids were detected during a high parasitemic acute phase and many of these reverted to baseline levels once a low parasitemic chronic phase was established. Plasmodium gene expression, studied in parallel in the macaques, revealed transcriptional changes in amine, fatty acid, lipid and energy metabolism genes, as well as variant antigen genes. Furthermore, a common set of amines, carnitines, and lipids distinguished acute from chronic malaria in plasma from human Plasmodium falciparum cases. In summary, distinct host-parasite metabolic environments have been uncovered that characterize acute versus chronic malaria, providing insights into the underlying host-parasite biology of malaria disease progression.
dc.identifier.citationCORDY, Regina Joice et al. MaHPIC consortium ; et.al . distinct amino acid and lipid perturbations characterize acute versus chronic malaria. JCI insight, Ann Arbor, v. 4, n. 9, e125156, 2019. DOI: 10.1172/jci.insight.125156. Disponível em: https://insight.jci.org/articles/view/125156. Acesso em: 29 jan. 2025.
dc.identifier.doi10.1172/jci.insight.125156
dc.identifier.issne- 2379-3708
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26518
dc.language.isoeng
dc.publisher.countryEstados unidos
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleDistinct amino acid and lipid perturbations characterize acute versus chronic malaria
dc.typeArtigo

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