Avaliação da eficácia do albendazol na lagochilascaríase murina experimental

Carregando...
Imagem de Miniatura

Data

1996-08

Título da Revista

ISSN da Revista

Título de Volume

Editor

Ruy de Souza Lino Junior

Resumo

Sixty inbred C57BL/6 mice were allocated into 3 equal groups, for the evaluatíon of the action of albendazol on 3rd stage Lagochilascaris minor larvae. Each animal was inoculated with IO3 infecting eggs of L, minor , through an esophageal probe. AH animais in groups I and II were treated with albendazol 400 mg/Kg/day by 30 days. Animais in group I received the drug on the 7th day and in group II on the 60th day post inoculation, due ío the migration pattern of L. minor larvae on the mouse organism. The mice in group III (controls) did not receive the drug. AU animais were sacrificied on the 5th day post drug ingestion. The criteria used for the evaluation of the efficacy of the drug was the number of living larvae retrieved from striated muscle, subcutaneous tíssue and viscus nodules. Efficacy leveis of 80,9% for group I and 66,3% for group II were observed. We conclude that both therapeutic protocols used were ineffective in the treatment againsí murine experimental lagochilascariasis.

Descrição

Palavras-chave

Albendazol, Lagochilascaríase, Terapêutica, Experimental lagochilascariasis, Efficacy

Citação

VIEIRA, Miguel Alípio; OLIVEIRA, Jayrson Araújo de; BARBOSA, Carlos Augusto Lopes. Avaliação da eficácia do albendazol na lagochilascaríase murina experimental. Revista de Patologia Tropical, Goiânia, v. 25, n. 2, p. 253-262, jul./dez. 1996. Disponível em: <https://www.revistas.ufg.br/iptsp/article/view/18484/10962>.