The "Little Iron Waltz": the ternary response of Paracoccidioides spp. to iron deprivation
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Data
2020
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Resumo
Paracoccidioides is a genus of thermodimorphic fungi that causes paracoccidioidomycosis.
When in the host, the fungus undergoes several challenges, including iron deprivation imposed by
nutritional immunity. In response to the iron deprivation triggered by the host, the fungus responds
in a ternary manner using mechanisms of high affinity and specificity for the uptake of Fe, namely
non-classical reductive iron uptake pathway, uptake of host iron proteins, and biosynthesis and uptake
of siderophores. This triple response resembles the rhythmic structure of a waltz, which features three
beats per compass. Using this connotation, we have constructed this review summarizing relevant
findings in this area of study and pointing out new discoveries and perspectives that may contribute
to the expansion of this “little iron waltz”.
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Siderophores, CFEM proteins, Reductive iron uptake pathway
Citação
SOUSA, Aparecido Ferreira de et al. The "Little Iron Waltz": the ternary response of Paracoccidioides spp. to iron deprivation. Journal of Fungi, Basel, v. 6, n. 4, e221, 2020. DOI: 10.3390/jof6040221. Disponível em: https://www.mdpi.com/2309-608X/6/4/221. Acesso em: 22 nov. 2024.