P53 gene: major mutations in neoplasias and anticancer gene therapy
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Data
2012-05
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Resumo
The p53 gene encodes a protein that has molecular
weight of 53kD and is also called p53 protein, being constantly
studied for its classic concept of “genome guardian”. This
gene plays a range of essential functions to ensure the cell cycle
control, in addition to playing a central role in carcinogenesis.
With respect to neoplasias, it prevents the neoplastic
transformation through three intricate mechanisms. Depending
on the extent of the mutation, different responses may be sent
by p53 and those range since the disruption of the cell cycle,
the correction of the mutation through the activation of repair
proteins or still, the induction of senescence or cell death by
apoptosis. This review aims to address the structural and
functional aspects of the p53 gene and protein, and also reaffirm
their participation in the carcinogenesis control, approaching
their major mutations and the anticancer gene therapy
involving this gene.
Key words: mutations, neoplasia, gene therapy, p53.
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Palavras-chave
Mutations, Neoplasia, Gene therapy, p53, Mutações, Neoplasia, Geneterapia
Citação
LIMA, Caroline Rocha de Oliveira; RABELO, Rogério Elias; VULCANI, Valcinir Aloísio Scalla; CARDOSO, Lorena Damasio; SOUSA, Nicaelle Luan de Moura; MOURA, Veridiana Maria Brianezi Dignani de. P53 gene: major mutations in neoplasias and anticancer gene therapy. Ciência Rural, Santa Maria, v. 42, n. 5, p. 845-853, May 2012.