Influence of surgical technique in the peritoneal carcinomatosis surgical wound implant: experimental model in mice
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Data
2015
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Resumo
The number of malignancies increased alarmingly. Surgery constitutes
one of the most efficient therapeutic modalities for the treatment of solid tumors. The neoplastic
implant in surgical wound is a complication whose percentage of occurrence reported in
the literature is variable, but sets with high morbidity and therapeutic difficulties. Protecting
the wound is one of the recommended principles of oncologic surgery. Aim: To evaluate
the influence of wound protection in the development of tumor implantation. Methods:
Sarcoma 180 tumor cells were used, with intraperitoneal inoculation in Swiss mice. After the
establishment of neoplastic ascites, animals were randomized into two groups of 10, each
group consisting of five males and five females. In both groups, laparotomy and manipulation
of intra-abdominal organs was performed. In a group laparotomy was performed using the
protection of the abdominal wound and the other group without it. On the 9 th postoperative
day macroscopic evaluation of the operative scar was performed, which was later removed for
microscopic evaluation. Results: There was microscopic infiltration of tumor cells in the wound
of all animals. However, the group that held the protection, infiltration was less intense when
compared to the group without it. The infiltration was also more severe in females than in
males of the same group. Conclusion: Tumor infiltration into the wound was more intense in
the group in which the protection of the surgical site was not performed, and in females when
compared to males of the same group.
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Palavras-chave
Ascites, Sarcoma 180, Models, animal, Ascites, Sarcoma 180, Models, animal
Citação
ROSA, Roberto Maranhão; CAIADO, Rafael Coelho; Paulo Roberto de Melo; LACERDA, Elisângela de Paula Silveira; SUGITA, Denis Masashi; MRUÉ, Fátima. Influence of surgical technique in the peritoneal carcinomatosis surgical wound implant: experimental model in mice. ABCD. Arquivos Brasileiros de Cirurgia Digestiva, São Paulo, v. 28, n. 1, p. 13-16, 2015.